AutismKB 2.0

Annotation Detail for GLIPR1


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Basic Information Top
Gene Symbol:GLIPR1 ( CRISP7,GLIPR,RTVP1 )
Gene Full Name: GLI pathogenesis-related 1
Band: 12q21.2
Quick LinksEntrez ID:11010; OMIM: 602692; Uniprot ID:GLIP1_HUMAN; ENSEMBL ID: ENSG00000139278; HGNC ID: 17001
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Metabolism of lipids and lipoproteins
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1860Brain tumor
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of GLIPR1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of GLIPR1 proteinaffects expression 20106945
C006632 arsenic trioxide arsenic trioxide results in decreased expression of GLIPR1 mRNAdecreases expression 19128835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of GLIPR1 mRNAincreases expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of GLIPR1 mRNAincreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GLIPR1 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of GLIPR1 mRNAincreases expression 20106945
C014347 decitabine decitabine affects the methylation of GLIPR1 promoteraffects methylation 18030365
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GLIPR1 mRNAaffects binding|decreases expression|increases activity 19710929
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GLIPR1 mRNAdecreases expression 17101203
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GLIPR1 mRNAincreases expression 20059583
C025643 vinclozolin vinclozolin affects the expression of GLIPR1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0411752688 15322242 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4619825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4620127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.5616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7519015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 16.1216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.1219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8417474063 20146248
MESH:D001943 Breast Neoplasms decitabine 1.8418320071 19208741
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8420435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4811589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9516227642 16192424 15673190 3786805 15700767 16050911 15721981 18705752 16124888 16097048 10355542 16011737
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.733084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.7321507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.7315553829 16217749 15073043 14691202 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7318788625
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2512490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8020419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.8019215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6212371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Cyclosporine 8.1019486331
MESH:D002779 Cholestasis pirinixic acid 8.1019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1516354765 8697196 12621046 15340226 15668235
MESH:D003110 Colonic Neoplasms decitabine 2.3517616700
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6120501625
MESH:D015179 Colorectal Neoplasms decitabine 2.6118981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5110525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5120055451 10048152 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.5014966744
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2415213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3419739265 14550746 16109766 12540782 10915739 12153990 11743745 19923254 16781746 10774834 18713872 16485898 15968718 2444490 17906064 17562736 11461765 12594235 16227642 19370779 14986274 16393943 16177239 10663392 11739529 19164858 12705907 11529661 19416960 11421492 14725611 17522070 11834606 12958197 19085960 15619225 18071297 12392966 11287661 19420014 16081117
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.3410092053 9327722 15027814 19336974 11566570 7440962 15998439 2869522 3786805 19085960 6623471 10915739 7120509 15968718 3732212 16177239 6884620 4309450 7179309 21278145 16227642 17522070
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 15322242 16714409
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.3319294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5412903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver arsenic trioxide 19.9615073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.9619224547 16239168 61145 17595544 15959796 16045604 12631006 12795759
MESH:D005234 Fatty Liver Cyclosporine 19.9619224547
MESH:D005234 Fatty Liver pirinixic acid 19.9619236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Carbon Tetrachloride 15.7718705752
MESH:D005355 Fibrosis Cyclosporine 15.7712639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.7720067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4216904648
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5216417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.5819215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 8.8518467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.8515340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2615340226 16354765 8697196 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007248 Infertility, Male decitabine 7.2317581917
MESH:D007248 Infertility, Male vinclozolin 7.2316467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.0512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.058314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8512371664
MESH:D007938 Leukemia arsenic trioxide 6.6715070760
MESH:D007938 Leukemia decitabine 6.6718980019 19235587
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9312560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 10.0619077051
MESH:D007951 Leukemia, Myeloid decitabine 10.0618454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0719850784 16467208 20471514 16968895 17050201
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.0718460780 18704418 19010910 19387464 17679729 18206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6818055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3015213294 16966277 17649720 17217047 19075265 19225113 12712474 15336539 17107899 16331271 9834237 15748426 16823087 12018890 19642359 15622746 19035177 12679006 17712046 11161223 16891316 17869043 16112521 16330433 11468182
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5116882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9316417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8816943688 16239168 11408273 16221502 21278145 17334410 17157831 17174718 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4617525996 16015684 14716833 18412020 17640975 18210741 15650968 18251166 18279442 17805973 11481614 18376398 15362042 12898905 12586293 17714472 15893842 12632514 18187930 18472332 18166357 16248980 18418968 15338365 17631135 18054572 16116963 15818738 12445421 17761835 18395095 17557913 12667390 14716496 18156304 14748882 18481824 17823541 15959796 12666154 17565644 18395914 17721639 12445418 16027843 18277467 12546737 17708605 17766677 16097048 14724832 17481882 15673190 14512876 12609069 16136751 17944888 18472094 18317297 12389079 15057751 17900296 18205269 16638106 18705752 17922224 15052691 14620537 15730626 15370692 10355542 17869086 17976157 12649538 20821823 16033810 12741479 15931870 18429990 18006644 12632512 17698563 18263696 15925388 12958196 18339082 15996030 15876570 18420326 15123356 16192424 13678700 16011737
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4612878042
MESH:D008107 Liver Diseases Acetaminophen 4.0019460945 11587558 12969438 12587719 19014921 16611625 19784758 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0015720792 16964402 15830285 16246199 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.8516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.8516899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 18.6318177683 15890375 9163691 2125692
MESH:D008113 Liver Neoplasms arsenic trioxide 18.6314682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.6321137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 18.6319294768
MESH:D008113 Liver Neoplasms pirinixic acid 18.6316377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.6316984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.828603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.8220377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.8215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.8212151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4615213294
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.9514755239
MESH:D008175 Lung Neoplasms arsenic trioxide 4.9519825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9520869020 18569708 6695378 18816296 20064080 20464547 18520028 20135361 17053015
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9511884234 19555203
MESH:D008223 Lymphoma decitabine 3.5219470736
MESH:D008545 Melanoma decitabine 2.2616505122 17785578
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009101 Multiple Myeloma arsenic trioxide 7.7115949261 19549372 19417148 11468182 14977855
MESH:D009101 Multiple Myeloma decitabine 7.7118172295
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.7516882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 7.7519157545 16882708 19010910 18608210
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1216624393
MESH:D009369 Neoplasms Benzo(a)pyrene 8.6111141357
MESH:D009369 Neoplasms decitabine 8.6119116145 17925555 19470736
MESH:D009369 Neoplasms pirinixic acid 8.6117405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2010525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.1216624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms decitabine 5.1219259094 19331143
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5515580305
MESH:D010190 Pancreatic Neoplasms decitabine 5.5519294695
MESH:D010235 Paraganglioma arsenic trioxide 4.3119927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.1411222880 11118676 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.1419015723 18220299 18042343
MESH:D055728 Primary Myelofibrosis decitabine 4.9017616702
MESH:D011469 Prostatic Diseases vinclozolin 5.1318220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.1419131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1417292933
MESH:D011472 Prostatitis vinclozolin 5.1318629315
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.5519155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1216646077
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.7510029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.758532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.7516192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4517007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.4520155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 3.4519037991
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.6819014326
MESH:D013964 Thyroid Neoplasms decitabine 7.6817967635
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1515213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.6412845720 11780464 12973940 20435036
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.6417053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.6417616700 19087683
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014604 Uveal Neoplasms decitabine 5.1317785578
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D009396 Wilms Tumor marker/mechanism 18030365
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
REACT:22258 Metabolism of lipids and lipoproteins
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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