AutismKB 2.0

Annotation Detail for KDELR3


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Basic Information Top
Gene Symbol:KDELR3 ( ERD2L3 )
Gene Full Name: KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
Band: 22q13.1
Quick LinksEntrez ID:11015; OMIM: NA; Uniprot ID:ERD23_HUMAN; ENSEMBL ID: ENSG00000100196; HGNC ID: 6306
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05110Vibrio cholerae infection
Pathway IDPathway Name
Diabetes pathways
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of KDELR3 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of KDELR3 proteinaffects expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of KDELR3 mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of KDELR3 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of KDELR3 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of KDELR3 mRNAincreases expression 18457598
18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of KDELR3 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of KDELR3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KDELR3 mRNAaffects cotreatment|increases expression 17942748
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of KDELR3 mRNAaffects cotreatment|increases expression 17183730
C055122 orlistat orlistat results in increased expression of KDELR3 mRNAincreases expression 18796435
C041786 palm oil palm oil results in increased expression of KDELR3 mRNAincreases expression 18042831
D010656 Phenylephrine Phenylephrine results in increased expression of KDELR3 mRNAincreases expression 18158353
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of KDELR3 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of KDELR3 mRNAdecreases expression 17426115
C010327 salinomycin salinomycin results in decreased expression of KDELR3 mRNAdecreases expression 19682730
D013629 Tamoxifen Tamoxifen affects the expression of KDELR3 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of KDELR3 mRNAdecreases expression 18495758
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KDELR3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of KDELR3 mRNAincreases expression 17942748
15328365
D014212 Tretinoin Tretinoin results in increased expression of KDELR3 mRNAincreases expression 17138961
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of KDELR3 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.2814514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.288875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9119490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8114692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.8716835633
MESH:D000505 Alopecia Tretinoin 3.6015955085
MESH:D000550 Amblyopia Valproic Acid 5.2317688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.5517497229
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.0917460149
MESH:D001161 Arteriosclerosis Dietary Fats 9.8615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.8611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.1615885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.1616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2616292516
MESH:D001249 Asthma Tretinoin 2.3416456186
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8519460635 18396377 20603192 18940202 18985861 17157402 15238991 16609825 18558336 18775368 19232924 17688650 17507914 18177632 18316065
MESH:D001471 Barrett Esophagus Tretinoin 4.3916935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.0620046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.1719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.1712125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.1716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.9815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.988888407
MESH:D001919 Bradycardia Phenylephrine 4.5415306635
MESH:D001943 Breast Neoplasms Dietary Fats 2.3420435547
MESH:D001943 Breast Neoplasms salinomycin 2.3419682730
MESH:D001943 Breast Neoplasms Tamoxifen 2.3415565566 19066611 19011961 19059307 19221464 20005174 18855134 21152245 19115204 19244106 17893378 16873071 18815881 21138602 18629630 16818667 15668708 18984771 19142967 11161223 18351453 17440819 19189210 19103187 20544844 20135344 19189212 19289846 16202921 18821012 19084267 17049068 19155303 20065188 19200415 17261762 20390343 19487384 19288272 18997820 20859285 16273361 19410462 17242785 18425577
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3420435547
MESH:D001943 Breast Neoplasms Tretinoin 2.3416166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5816813970
MESH:D019121 Burkholderia Infections orlistat 6.6417874328
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7710355542 15673190 16011737 16227642 16192424 15700767 16124888 15721981 16097048 16050911 18705752 3786805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4919066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1616168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.833084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.8321507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.8318788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.8316924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.831917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2816051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6017572228
MESH:D006332 Cardiomegaly Phenylephrine 6.8415728586 11754973 17124262 17287366 16170337 11179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.8418850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 7.1810977129
MESH:D002386 Cataract Tretinoin 7.1817460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5112371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5816129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7020734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002779 Cholestasis Cyclosporine 13.2519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.2516919318 11677210 17681005 17110522 16105132 15861022 17333356
MESH:D002779 Cholestasis pirinixic acid 13.2519176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1616461808
MESH:D002916 Chylothorax orlistat 6.6417003701
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.7412621046 8697196 15668235 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 5.749407595
MESH:D003092 Colitis Tretinoin 3.6917035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7515322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.7514991402 16925845 9211117 10589399 9125849 17551590 9142499 9664655 8800419 9224671
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.7516575769 8888407 17688650
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3519031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D048909 Diabetes Complications orlistat 5.8419207292
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4619279558
MESH:D003967 Diarrhea orlistat 4.7020002075
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.9016177239 16393943 19416960 11743745 17522070 18713872 14725611 10774834 11421492 16485898 15968718 19164858 19085960 12153990 18071297 12958197 17906064 19420014 12705907 19370779 11461765 12392966 16781746 12540782 11287661 17562736 19739265 2444490 10915739 14550746 11834606 11739529 16081117 19923254 16227642 15619225 14986274 11529661 16109766 10663392 12594235
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.9010915739 10092053 16227642 3786805 21278145 7179309 17522070 15998439 19085960 7120509 4309450 6884620 11566570 19336974 2869522 15027814 9327722 6623471 16177239 3732212 15968718 7440962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.9020420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 8.901733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4418367378
MESH:D004421 Dystonia Valproic Acid 4.031851702
MESH:D004487 Edema pirinixic acid 6.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.9518230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.9518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.8912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.8919031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.3917893378 20544844 16202921 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 7.3916569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0010568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.1417275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.923922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9220417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.577562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.287750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.063659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.7811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.789664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 36.7917595544 12631006 16239168 15959796 16045604 12795759 19224547 61145
MESH:D005234 Fatty Liver Cyclosporine 36.7919224547
MESH:D005234 Fatty Liver Dietary Fats 36.7917967931 18296743 19551842 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 36.7915345470
MESH:D005234 Fatty Liver pirinixic acid 36.7920131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 36.7914986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 36.7919224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8916575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.118888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1719069698
MESH:D005355 Fibrosis Carbon Tetrachloride 27.6318705752
MESH:D005355 Fibrosis Cyclosporine 27.6312639820 12168785
MESH:D005355 Fibrosis Dietary Fats 27.6318296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 27.6320067830
MESH:D005355 Fibrosis Tretinoin 27.6317994277
MESH:D005414 Flatulence orlistat 6.6420002075
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.218708960
MESH:D005909 Glioblastoma Tretinoin 2.9917312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1616084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5010048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.5014991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5819900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 8.2216221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.2215340226 12621046 16120746
MESH:D006849 Hydrocephalus Valproic Acid 4.8617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.058697196 16354765 15340226 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 7.5716870215
MESH:D006930 Hyperalgesia Tretinoin 7.5716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5216899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5721332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5516778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006949 Hyperlipidemias Dietary Fats 9.6221332399
MESH:D006949 Hyperlipidemias orlistat 9.6221332399
MESH:D006973 Hypertension Cyclosporine 8.5610903974
MESH:D006973 Hypertension Phenylephrine 8.5612717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.5618670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0715338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.6116612254
MESH:D006984 Hypertrophy Phenylephrine 4.5312791704 18502941
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4717937319
MESH:D007249 Inflammation Dietary Fats 8.2120412841
MESH:D007249 Inflammation Tamoxifen 8.2119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.2112200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 12.4311836018 18457598
MESH:D007333 Insulin Resistance orlistat 12.4317201808
MESH:D007333 Insulin Resistance pirinixic acid 12.4316306350
MESH:D007410 Intestinal Diseases Tretinoin 3.7517994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.8716580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.8715992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4415604871
MESH:D007674 Kidney Diseases Acetaminophen 5.7515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.7518776723 10903974 8314463
MESH:C531755 Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules orlistat 6.6417185156
MESH:D007680 Kidney Neoplasms Cyclosporine 7.2412371664
MESH:D007680 Kidney Neoplasms Tamoxifen 7.2418625569
MESH:D007938 Leukemia Tretinoin 2.7617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8717596541 16294345 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.8716294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1419075265 17217047 17712046 17506722 17361223 16935935 16891316 17301526 19225113 16766008 17107899 16331271 16788101 17368321 17339181 9834237 16823087 19029980 17294898 15748426 19642359 12679006 17649720 16140955 19035177
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.299224671
MESH:D008064 Lipidoses Tamoxifen 3.1417567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 11.1611408273 17334410 16239168 17174718 16943688 17157831 11903743 16221502 21278145
MESH:D008103 Liver Cirrhosis Dietary Fats 11.1618296743
MESH:D008103 Liver Cirrhosis orlistat 11.1617404856
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.7015650968 14748882 12586293 18210741 15893842 17922224 15996030 15818738 12958196 17805973 18418968 12445418 14724832 12649538 15876570 18277467 18429990 12632514 10355542 17481882 18263696 16097048 15959796 18395914 17525996 16638106 12741479 18054572 18205269 15338365 12445421 17823541 17976157 16248980 11481614 17714472 15052691 17698563 16011737 12898905 17640975 14620537 20821823 15730626 15123356 15925388 18317297 12389079 17766677 16136751 16116963 14512876 17721639 18251166 16027843 16015684 18156304 18006644 15362042 15673190 18187930 18376398 17565644 12666154 18339082 14716496 18279442 18412020 13678700 17900296 17631135 17869086 12632512 18472094 16192424 17761835 12667390 15370692 14716833 17708605 15057751 18472332 18166357 15931870 17944888 17557913 16033810 12546737 18705752 12609069 18481824 18420326 18395095
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.7015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.7018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.7012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.7016248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 3.8819014921 11587558 19784758 16611625 19460945 16610002 12969438 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.8817285989 16246199 15720792 16964402 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.3516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.3514706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.159163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.1519294768
MESH:D008113 Liver Neoplasms pirinixic acid 14.1516377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 14.1516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.1516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.738603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.7315583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.7312151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2617228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.3714755239
MESH:D008175 Lung Neoplasms Tamoxifen 3.3718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3719555203 11884234
MESH:D008207 Lymphatic Metastasis orlistat 5.8720805790 18770866
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7519428831
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 6.3719682730
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.3711731420 19196722 14580682 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.5519453300
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma orlistat 5.2618770866 20805790
MESH:D008545 Melanoma Tamoxifen 5.2619393235 12393984
MESH:D008545 Melanoma Tretinoin 5.2616752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D008591 Meningomyelocele Tretinoin 4.4116940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7916801185
MESH:D008881 Migraine Disorders Valproic Acid 3.1718765137 18803445
MESH:D009135 Muscular Diseases orlistat 10.7018430571
MESH:D009135 Muscular Diseases pirinixic acid 10.7016239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.018888407
MESH:D009164 Mycobacterium Infections orlistat 5.4921442799
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.3517596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.3517596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9316411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5119410462
MESH:D009369 Neoplasms orlistat 8.3618710210
MESH:D009369 Neoplasms pirinixic acid 8.3617405874
MESH:D009369 Neoplasms Tretinoin 8.3616594593 16946489
MESH:D009374 Neoplasms, Experimental orlistat 5.0419381703
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0019200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic orlistat 5.3317012255
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2719348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.4614600291
MESH:D009421 Nervous System Malformations Tretinoin 9.469125849
MESH:D009436 Neural Tube Defects Tretinoin 7.269142499
MESH:D009436 Neural Tube Defects Valproic Acid 7.2616359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8518514411
MESH:C541083 Non-alcoholic Fatty Liver Disease orlistat 5.5417404856
MESH:D009765 Obesity Dietary Fats 7.5418457598 17217161 19632207 21332399 11836018 16723640 20132043 18674790 20518802
MESH:D009765 Obesity orlistat 7.5416938137 19461584 20065556 21442799 18773755 20518802 19207292 20599501 20002075 21438711 19046740 20540997
MESH:D009765 Obesity pirinixic acid 7.5420558911
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3416936753
MESH:D010146 Pain Acetaminophen 6.5316870215
MESH:D010146 Pain Tretinoin 6.5316870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4515976015
MESH:D010195 Pancreatitis orlistat 4.8316938137 20065556
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D011085 Polycystic Ovary Syndrome orlistat 5.2717201808
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.4411399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.4420603192
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1615067354
MESH:D011507 Proteinuria Tretinoin 3.5916636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.3015861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.5412752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2216882103
MESH:D011625 Pterygium Tretinoin 4.7816723453
MESH:D012035 Refsum Disease orlistat 6.0620871815
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.8016116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.8019155313
MESH:D012559 Schizophrenia Valproic Acid 2.0715737665 19110320
MESH:D012640 Seizures Valproic Acid 2.7211044598 11738929 1511512 15475178 3137016 17978042 14763951 16876388
MESH:D012852 Sinusitis Phenylephrine 4.697327846
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.378532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.3716192470
MESH:D012878 Skin Neoplasms Tretinoin 9.3716467112
MESH:D013088 Spermatocele Ethinyl Estradiol 11.5616709447
MESH:D013088 Spermatocele Tamoxifen 11.5616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0319457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.7619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.5412833885
MESH:D013274 Stomach Neoplasms orlistat 2.9719381703
MESH:D013274 Stomach Neoplasms Tretinoin 2.9717261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0116026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.7716051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.2317262798
MESH:D014376 Tuberculosis Tretinoin 3.2116040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.513119515
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.358653321 16712894 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.638888407
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6616129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2814692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.6116752155
MESH:D014605 Uveitis Cyclosporine 3.981336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5214671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.0416761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D015430 Weight Gain Dietary Fats 3.7216723640
MESH:D009396 Wilms Tumor Tretinoin 3.9516287080
MESH:D014985 Xerophthalmia Cyclosporine 4.4417120751
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
KEGG:05110 Vibrio cholerae infection
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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