AutismKB 2.0

Annotation Detail for RIPK3


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Basic Information Top
Gene Symbol:RIPK3 ( RIP3 )
Gene Full Name: receptor-interacting serine-threonine kinase 3
Band: 14q12
Quick LinksEntrez ID:11035; OMIM: 605817; Uniprot ID:RIPK3_HUMAN; ENSEMBL ID: ENSG00000129465; HGNC ID: 10021
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04623Cytosolic DNA-sensing pathway
No data
No data
No data
Pathway IDPathway Name
500448Viral dsRNA:TLR3:TRIF Complex Activates RIP1
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of RIPK3 mRNAincreases expression 19933214
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RIPK3 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of RIPK3 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RIPK3 mRNAaffects expression 16483693
C006780 bisphenol A bisphenol A results in increased expression of RIPK3 mRNAincreases expression 18180321
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in increased expression of RIPK3 mRNAincreases expression 17553608
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RIPK3 mRNAaffects expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of RIPK3 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RIPK3 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RIPK3 mRNAincreases expression 17557909
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of RIPK3 mRNAincreases expression 17317680
D008701 Methapyrilene Methapyrilene results in increased expression of RIPK3 mRNAincreases expression 16393664
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of RIPK3 mRNAincreases expression 17616710
D010615 Phenacetin Phenacetin results in increased expression of RIPK3 mRNAincreases expression 17082564
C030299 phenylhydrazine phenylhydrazine results in increased expression of RIPK3 mRNAincreases expression 17082564
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RIPK3 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of RIPK3 mRNAdecreases expression 17426115
D013629 Tamoxifen Tamoxifen affects the expression of RIPK3 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RIPK3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RIPK3 mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8711752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8114692618
MESH:D000236 Adenoma 2-Acetylaminofluorene 3.7410737359
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 6.046705139
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.9716835633
MESH:D000740 Anemia Phenacetin 15.172444515
MESH:D000740 Anemia phenylhydrazine 15.172444515
MESH:D000740 Anemia Tetrachlorodibenzodioxin 15.1711748828
MESH:D000743 Anemia, Hemolytic Phenacetin 11.071949026 17082564 17698508
MESH:D000743 Anemia, Hemolytic phenylhydrazine 11.0717082564 17084956 17698508
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D001862 Bone Resorption bisphenol A 3.8711985600
MESH:D001943 Breast Neoplasms bisphenol A 1.8517123778
MESH:D001943 Breast Neoplasms Tamoxifen 1.8519189212 17242785 20544844 21152245 19084267 19059307 16202921 19289846 19487384 16818667 15565566 19103187 17440819 18425577 19410462 16273361 20135344 19200415 19142967 18984771 18351453 20065188 19221464 18997820 19189210 18821012 16873071 19066611 19155303 19244106 18815881 18629630 17893378 19288272 17049068 20390343 21138602 17261762 19115204 20859285 15668708 20005174 19011961 18855134 11161223
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8520435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7916097048 15721981 16011737 16050911 18705752 16227642 16124888 15700767 3786805 15673190 10355542 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5219066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.8916705839
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 8.893084413 6705139 3581430 10737359 17761372
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.893084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.8918788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.8916924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.0117123778
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3718850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.776135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.7515861022 16919318 17110522 17681005 11677210 16105132 17333356
MESH:D002779 Cholestasis pirinixic acid 7.7519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.108697196 12621046 16354765 15668235 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 10048152 20055451
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0318551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3819031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4819279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.9518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.9519164858 16227642 19923254 19739265 15968718 11287661 10774834 19416960 12540782 11743745 10663392 14725611 12153990 10915739 17522070 12958197 15619225 16109766 2444490 11834606 16393943 18713872 19420014 12705907 12392966 11461765 12594235 16177239 14550746 18071297 16485898 17906064 11529661 16781746 17562736 19085960 19370779 11739529 11421492 14986274 16081117
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.957120509 16177239 15027814 9327722 6884620 10915739 21278145 16227642 10092053 2869522 3786805 4309450 6623471 19085960 7179309 7440962 15998439 15968718 3732212 19336974 11566570 17522070
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.9520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D004487 Edema pirinixic acid 6.5512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9318230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.9812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.9819031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0516202921 19155303 20544844 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.029294722 10568697
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.7815547733 15623463 16805852 15150132 16510608 15547721 15878914 16704527 15264214
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 18.8016239168 12795759 15959796 61145 19224547 12631006 16045604 17595544
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.8015345470
MESH:D005234 Fatty Liver pirinixic acid 18.8019236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 18.8014986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2019069698
MESH:D005355 Fibrosis Carbon Tetrachloride 8.6418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.6420067830
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.356705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.416705139
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6019110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 8.3118467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.3115340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0815340226 16959395 8697196 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5516899240
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9118670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4917937319
MESH:D007249 Inflammation Tamoxifen 4.8919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8912200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 7.3216393666
MESH:D007333 Insulin Resistance pirinixic acid 7.3216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2015629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.3916705839
MESH:D007680 Kidney Neoplasms Tamoxifen 7.3918625569
MESH:D008064 Lipidoses Tamoxifen 3.1615342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8116221502 11408273 17157831 16943688 11903743 17174718 16239168 17334410 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.9214748882 15123356 14620537 17640975 18472332 17766677 15925388 15876570 18006644 10355542 14512876 18210741 17922224 18339082 17869086 18166357 17708605 16248980 16638106 13678700 18277467 12632512 18251166 16192424 12389079 17631135 12666154 18420326 17976157 17565644 17698563 18187930 15650968 15338365 12649538 12632514 18263696 17525996 18317297 12546737 14716496 18205269 18472094 18481824 18054572 18412020 17481882 12898905 15052691 17557913 15959796 16027843 16136751 18156304 15370692 16097048 17823541 18395095 12445418 17805973 17761835 17721639 15818738 11481614 17714472 17900296 18376398 20821823 16011737 15673190 15931870 12445421 15893842 12586293 16015684 15730626 18418968 14724832 12741479 18395914 18279442 12609069 12958196 15362042 15996030 16033810 17944888 18429990 12667390 16116963 14716833 18705752 15057751
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9215474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.9218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9212878042
MESH:D008107 Liver Diseases Acetaminophen 3.9016610002 16611625 11587558 19014921 19784758 19460945 12969438 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9015720792 17285989 16246199 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.4217185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.4216899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 21.957678174
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 21.9514678523 10737359 16273603 10672840 18001218 11376686
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 21.9519294768
MESH:D008113 Liver Neoplasms Methapyrilene 21.9515890375
MESH:D008113 Liver Neoplasms pirinixic acid 21.9520007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 21.9516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.9516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.162876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 14.166150874 534488 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.1612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.1612151625
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 3.4911376686
MESH:D008175 Lung Neoplasms Tamoxifen 3.4918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4911884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7819428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6214580682 19196722 11731420 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.5819453300
MESH:D008545 Melanoma Tamoxifen 1.8812393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008708 Methemoglobinemia Phenacetin 4.9616296465 4834387 3537620 1949026
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9516411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.8818551238 7678174
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009369 Neoplasms pirinixic acid 1.9517405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0319189210 19200415 19196722
MESH:D009421 Nervous System Malformations bisphenol A 9.6111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.6114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4316049721
MESH:D010049 Ovarian Diseases bisphenol A 5.0111985600
MESH:D010146 Pain Acetaminophen 2.3916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.5810548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.5811896295 11399792 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.2120887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.2916740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.3315861022 16919318
MESH:D011629 Puberty, Precocious bisphenol A 4.8110548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5418551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.6616709447
MESH:D013088 Spermatocele Tamoxifen 11.6616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0619457130
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3212958204 17575124
MESH:D019966 Substance-Related Disorders bisphenol A 4.0016684133 16045194
MESH:D013436 Sulfhemoglobinemia Phenacetin 6.59978859
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.0516049721
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 12.0515867355 15289314 1399818
MESH:D001749 Urinary Bladder Neoplasms Phenacetin 12.0511144890
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.058653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3410091137
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D014591 Uterine Diseases bisphenol A 5.0414652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
Pathway ID Pathway Name
KEGG:04623 Cytosolic DNA-sensing pathway
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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