AutismKB 2.0

Annotation Detail for PIM2


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Basic Information Top
Gene Symbol:PIM2 ( - )
Gene Full Name: pim-2 oncogene
Band: Xp11.23
Quick LinksEntrez ID:11040; OMIM: 300295; Uniprot ID:PIM2_HUMAN; ENSEMBL ID: ENSG00000102096; HGNC ID: 8987
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05221Acute myeloid leukemia
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
2051Leukemia
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PIM2 mRNAaffects expression 17562736
D000111 Acetylcysteine Acetylcysteine results in increased expression of PIM2 mRNAincreases expression 16084531
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PIM2 mRNAincreases expression 20064835
C471992 bosutinib bosutinib results in decreased activity of PIM2 proteindecreases activity 17114238
C045651 epigallocatechin gallate epigallocatechin gallate results in increased expression of PIM2 mRNAincreases expression 16084531
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PIM2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PIM2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PIM2 mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin results in decreased expression of PIM2 mRNAdecreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1814514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3520127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3514692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000505 Alopecia Tretinoin 3.8115955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.6715885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.6716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma epigallocatechin gallate 5.4416516891
MESH:D001249 Asthma Tretinoin 5.4416456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 5.3719761891
MESH:D001471 Barrett Esophagus Tretinoin 4.6816935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.7616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8017474063 20146248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8020435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8016873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9316813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.5416168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.963084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 2.961917145
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 7.9817015178
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.9820419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.9816051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4916120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 7.6610977129
MESH:D002386 Cataract Tretinoin 7.6617460283
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 4.0218226522
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9316129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0517333356 16105132 11677210 16919318 15861022 17681005 17110522
MESH:D002822 Choriocarcinoma Tretinoin 5.5416461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0512621046 15340226 16354765 8697196 15668235
MESH:D002972 Cleft Palate Tretinoin 6.059407595
MESH:D003092 Colitis Tretinoin 4.0117035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5010048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.509142499 10589399 9664655 17551590 8800419 16925845 9224671 9125849 9211117 14991402
MESH:D003550 Cystic Fibrosis Acetylcysteine 4.6019747007
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 4.7816988119
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.7817107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6219739265 14550746 16485898 17562736 16177239 19416960 19085960 11743745 17522070 10663392 16227642 19370779 15968718 18713872 19164858 11739529 11421492 11461765 11834606 15619225 12958197 16393943 16109766 11529661 2444490 12392966 19923254 12705907 16081117 10774834 11287661 16781746 10915739 12540782 17906064 12153990 14986274 18071297 12594235 14725611 19420014
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 6.6211287661
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 13.2315322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 13.2318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2516569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.4311564622
MESH:D005124 Eye Abnormalities Tretinoin 9.439664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.0515345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6620067830
MESH:D005355 Fibrosis Tretinoin 9.6617994277
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005909 Glioblastoma Tretinoin 3.1517312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.5416084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.7520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.7510048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 11.7514991402 9664655
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216959395 18606429 15340226 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 8.2716870215
MESH:D006930 Hyperalgesia Tretinoin 8.2716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8816778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612878042 12200463
MESH:D007410 Intestinal Diseases Tretinoin 4.0717994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.7616580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.7615992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D007938 Leukemia Tretinoin 2.8717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9416932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1117596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3016935935 16766008 17301526 17294898 17649720 16331271 19029980 17712046 16140955 17107899 16891316 16788101 12679006 17339181 19225113 15748426 17506722 19035177 17361223 19075265 17217047 19642359 17368321 16823087 9834237
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.479224671
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 3.7217481882
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.7212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.7216248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6719784758 12587719 12969438 16610002 19014921 19460945 16611625 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.5920195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2412151625
MESH:D008171 Lung Diseases Acetylcysteine 4.2012815614
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2420064080 17053015 20135361 18520028 6695378 20464547 20869020 18816296 18569708
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2411884234 19555203
MESH:D008527 Medulloblastoma Tretinoin 2.8617453147
MESH:D008545 Melanoma epigallocatechin gallate 3.8017992120 11746506
MESH:D008545 Melanoma Tretinoin 3.8016752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008591 Meningomyelocele Tretinoin 4.7316940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 5.8317962980
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2017596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009362 Neoplasm Metastasis Acetylcysteine 3.6614720322
MESH:D009369 Neoplasms Benzo(a)pyrene 5.3411141357
MESH:D009369 Neoplasms Tretinoin 5.3416946489 16594593
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.4714600291
MESH:D009421 Nervous System Malformations Tretinoin 10.479125849
MESH:D009436 Neural Tube Defects Acetylcysteine 8.1319446573
MESH:D009436 Neural Tube Defects Tretinoin 8.139142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4016936753
MESH:D010146 Pain Acetaminophen 7.2616870215
MESH:D010146 Pain Tretinoin 7.2616870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5315976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311399792 11896295 11118676 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D011507 Proteinuria Tretinoin 3.8616636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D011625 Pterygium Tretinoin 5.1316723453
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 4.7812210543
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3616283617 16116481
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.9710029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.9716192470
MESH:D012878 Skin Neoplasms Tretinoin 9.9716467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.392093021 20155912
MESH:D013274 Stomach Neoplasms Tretinoin 2.3917261132
MESH:D013276 Stomach Ulcer Acetylcysteine 4.2317918041
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2117045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0216051514
MESH:D014376 Tuberculosis Tretinoin 3.3616040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2517053015
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9016129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.9916752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.3416761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D009396 Wilms Tumor Tretinoin 4.1816287080
Pathway ID Pathway Name
KEGG:05221 Acute myeloid leukemia
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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