AutismKB 2.0

Annotation Detail for CHD1


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Basic Information Top
Gene Symbol:CHD1 ( DKFZp686E2337 )
Gene Full Name: chromodomain helicase DNA binding protein 1
Band: 5q15-q21.1
Quick LinksEntrez ID:1105; OMIM: 602118; Uniprot ID:CHD1_HUMAN; ENSEMBL ID: ENSG00000153922; HGNC ID: 1915
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CHD1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CHD1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CHD1 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CHD1 mRNAdecreases expression 20382639
19150397
D016572 Cyclosporine Cyclosporine results in increased expression of CHD1 mRNAincreases expression 20106945
C121718 dicyclanil dicyclanil results in increased expression of CHD1 mRNAincreases expression 15664270
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CHD1 mRNAincreases expression 17942748
D007213 Indomethacin Indomethacin results in decreased expression of CHD1 mRNAdecreases expression 16984733
C051890 irinotecan irinotecan metabolite results in decreased expression of CHD1 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of CHD1 mRNAdecreases expression 15956246
D009151 Mustard Gas Mustard Gas results in increased expression of CHD1 mRNAincreases expression 15674844
C006253 pirinixic acid pirinixic acid results in increased expression of CHD1 mRNAincreases expression 18445702
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of CHD1 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of CHD1 mRNAdecreases expression 19244175
C025643 vinclozolin vinclozolin affects the expression of CHD1 mRNAaffects expression 19015723
C025643 vinclozolin vinclozolin results in decreased expression of CHD1 mRNAdecreases expression 18042343
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of CHD1 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of CHD1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.5114692618
MESH:D000230 Adenocarcinoma Indomethacin 4.5116537180
MESH:D000236 Adenoma Indomethacin 3.4811497255
MESH:D018248 Adenoma, Liver Cell dicyclanil 10.8117162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8116434500
MESH:D016301 Alveolar Bone Loss Indomethacin 5.4717225004
MESH:D000544 Alzheimer Disease Indomethacin 2.7117627676 15579461
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6819015723
MESH:D001014 Aortic Aneurysm Indomethacin 4.9110231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.9410388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D018771 Arthralgia Indomethacin 5.272160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.8311248219
MESH:D001249 Asthma Mustard Gas 2.7210378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001477 Bartter Syndrome Indomethacin 5.0610684365
MESH:D001768 Blister Mustard Gas 5.2419167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2019483382
MESH:D001929 Brain Edema Indomethacin 5.1211481608
MESH:D002545 Brain Ischemia Indomethacin 4.5012524144
MESH:D001943 Breast Neoplasms Indomethacin 2.8317401462
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2415286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.0717687719 10378619
MESH:D002056 Burns Indomethacin 4.7810459503
MESH:D002100 Cachexia Indomethacin 5.0915141370 15625704 11239499 16537180
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0016050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.9816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.9816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.983084413
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 8.9817162532
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 8.9816391822
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.8111053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.4311352223 14736730 18791128
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.4017341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 2.8615482327 12636206
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.356135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.3520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.3512371664
MESH:D002764 Cholecystitis Indomethacin 5.2711181007
MESH:D002779 Cholestasis Cyclosporine 13.5819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.5816105132 16919318 17681005 15861022 17110522 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 13.5819176532
MESH:D003092 Colitis Selenium 3.8517936198
MESH:D003110 Colonic Neoplasms Indomethacin 4.1315625704 15786552 11260862 15963497 15936596 15637740
MESH:D003110 Colonic Neoplasms irinotecan 4.1317725105 17287894
MESH:D015179 Colorectal Neoplasms Indomethacin 2.8717054584 12606626 11197048 18059344
MESH:D015179 Colorectal Neoplasms irinotecan 2.8715273666 16391804 18259882 17454858 17159606 16303861 18509181
MESH:D018352 Coronavirus Infections Indomethacin 5.8117302372
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9119769572
MESH:D003456 Cryptorchidism vinclozolin 4.4114966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.1418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.1418551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003967 Diarrhea Indomethacin 3.867907874 7237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.1018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.1018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.1016109766 19739265 14725611 12540782 16177239 10915739 16781746 12594235 12958197 14550746 14986274 2444490 12705907 10663392 11834606 11743745 16227642 18713872 19085960 11529661 16081117 11287661 11461765 12153990 18071297 15619225 17522070 19923254 19416960 11739529 11421492 19164858 17906064 19420014 19370779 12392966 15968718 16393943 16485898 17562736 10774834
MESH:D056486 Drug-Induced Liver Injury Selenium 9.1015131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.2318043480 16133044 18446180 17190690 16326151 12774134
MESH:D004381 Duodenal Ulcer Indomethacin 4.2017045617 11595415 11535926 17351913 16699067 11991626 17151854 17202747 17329845 10671773 11595431
MESH:C538011 Eales disease Vitamin E 4.809068938
MESH:D004487 Edema Indomethacin 11.9010653021 19703484 8273558 7907874 7990266 16100529 8985016
MESH:D004487 Edema Mustard Gas 11.9011402378 9260866 11428647 11428631
MESH:D004487 Edema pirinixic acid 11.9012083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2512538720
MESH:D004715 Endometriosis Indomethacin 4.2015652904
MESH:D019446 Endotoxemia Indomethacin 4.5818509659
MESH:D004751 Enteritis Indomethacin 4.8416328016 17763956 10567023
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.0617980183
MESH:D004802 Eosinophilia Indomethacin 4.1211298111
MESH:D004890 Erythema Mustard Gas 5.249357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6920426865
MESH:D004938 Esophageal Neoplasms Indomethacin 4.6911005569
MESH:D005234 Fatty Liver Cyclosporine 13.3219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.3215345470
MESH:D005234 Fatty Liver pirinixic acid 13.3219236843 20131406
MESH:D005334 Fever Indomethacin 4.1711852909 17627676 10431976
MESH:D005354 Fibrosarcoma Indomethacin 4.9810962813
MESH:D005355 Fibrosis Cyclosporine 9.1412168785 12639820
MESH:D005355 Fibrosis Indomethacin 9.1417994277
MESH:D005499 Folliculitis Indomethacin 5.2711298111
MESH:D005756 Gastritis Acetaminophen 11.4816983495
MESH:D005756 Gastritis Indomethacin 11.4815046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4016417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D005909 Glioblastoma Indomethacin 3.6012870263
MESH:D005910 Glioma Indomethacin 3.2416487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.3311849393
MESH:D006073 Gout Indomethacin 5.4311248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.7815482327
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0116080930
MESH:D006333 Heart Failure pirinixic acid 7.0620558911
MESH:D006333 Heart Failure Selenium 7.0617162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.6215633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.7515135802
MESH:D006529 Hepatomegaly pirinixic acid 3.0718467677 16221962 19176532 19772884
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7216863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.0714716179
MESH:D006930 Hyperalgesia Acetaminophen 7.9716870215
MESH:D006930 Hyperalgesia Indomethacin 7.9712727271
MESH:D034321 Hyperamylasemia Indomethacin 5.8117883296
MESH:D006940 Hyperemia Indomethacin 5.0912524144
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006949 Hyperlipidemias Indomethacin 4.2217546600
MESH:D006973 Hypertension Cyclosporine 2.1210903974
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816945680 16569931
MESH:D007077 Ileal Diseases Indomethacin 5.1218306037 10574470
MESH:D007079 Ileitis Indomethacin 5.4310651667 16133968 10647630
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.4716133044
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.7817937319
MESH:D007248 Infertility, Male vinclozolin 6.7816467254
MESH:D007249 Inflammation Indomethacin 5.553291741 7812673 12568917
MESH:D007249 Inflammation Mustard Gas 5.5511428647 11428620 16001271 8975870 11428631 9260866 9357497 17524151 11402378
MESH:D007251 Influenza, Human Selenium 11.2916624496
MESH:D007251 Influenza, Human Vitamin E 11.2916624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6616306350
MESH:D007410 Intestinal Diseases Indomethacin 4.4015610444 11713966 17994277 17329856 11686837 15831440 18236018 11855677 10210152
MESH:D019586 Intracranial Hypertension Indomethacin 5.4715241188
MESH:D007579 Jejunal Diseases Indomethacin 5.1210574470 16133968 18306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Acetaminophen 14.7012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 14.708314463 10903974 18776723
MESH:D007674 Kidney Diseases Indomethacin 14.7017190690
MESH:D007674 Kidney Diseases Vitamin E 14.7012488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9416518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.6316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.6316705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.6312371664
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.9511703811 10320625 12228301
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.9615631656 10785260 16572323
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6418360721
MESH:D007964 Leukocytosis Indomethacin 5.4716537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.8117980183
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8116417039
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.8111479899
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 3.5918194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5915474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5916169303
MESH:D008107 Liver Diseases Acetaminophen 1.6419460945 11587558 19784758 16610002 12969438 16611625 19014921 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2917185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.677678174
MESH:D008113 Liver Neoplasms dicyclanil 7.6720118626
MESH:D008113 Liver Neoplasms pirinixic acid 7.6720007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.572876784 2876786 6135515
MESH:D008171 Lung Diseases Mustard Gas 7.6618161513 18702808
MESH:D008171 Lung Diseases Vitamin E 7.6616863852
MESH:D008175 Lung Neoplasms Indomethacin 3.6311497255 11053908 16537180
MESH:D008175 Lung Neoplasms Mustard Gas 3.638781369 3148597
MESH:D008175 Lung Neoplasms Vitamin E 3.6311062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.7915318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008654 Mesothelioma Selenium 2.8115107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D008881 Migraine Disorders Indomethacin 3.7111903285
MESH:D009062 Mouth Neoplasms Indomethacin 4.0312636206
MESH:D052016 Mucositis irinotecan 5.0917159606
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.6318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.6318551238 7678174
MESH:D009362 Neoplasm Metastasis Indomethacin 6.2511053908 11239499 16537180
MESH:D009362 Neoplasm Metastasis irinotecan 6.2518259882
MESH:D009369 Neoplasms pirinixic acid 1.9717405874
MESH:D009374 Neoplasms, Experimental Indomethacin 4.2110663608 15625704
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3318481113 19348381
MESH:D009447 Neuroblastoma irinotecan 3.508761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.5518514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 8.5512349958
MESH:D017599 Neuroectodermal Tumors irinotecan 4.818761367
MESH:D009503 Neutropenia Mustard Gas 4.0316761898 7688884
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.276374098
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.0612819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.0616049721
MESH:D010003 Osteoarthritis Indomethacin 3.707009135
MESH:D010146 Pain Acetaminophen 6.9416870215
MESH:D010146 Pain Indomethacin 6.943291741 17440234 13679232 17627676
MESH:D010149 Pain, Postoperative Indomethacin 4.7818702446 12538197
MESH:D010195 Pancreatitis Indomethacin 3.9815028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.8116537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.1712349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.8111903285
MESH:D010437 Peptic Ulcer Indomethacin 5.2311148446
MESH:D010518 Periodontitis Indomethacin 5.0117225004
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D011041 Poisoning Mustard Gas 3.8515727166
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D047928 Premature Birth Indomethacin 5.2017000239
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.9819015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.0218220299
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3015084515
MESH:D011472 Prostatitis vinclozolin 5.0218629315
MESH:D011507 Proteinuria Indomethacin 4.2211849393
MESH:D011537 Pruritus Ethinyl Estradiol 9.8015861022 16919318
MESH:D011537 Pruritus Mustard Gas 9.8018058305
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9417894541 17620002 17266442 10334151 17720292
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D012640 Seizures 2,4-dinitrotoluene 5.9918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.9918551238
MESH:D012871 Skin Diseases Mustard Gas 5.0716961503 15451306 12880345
MESH:D012871 Skin Diseases Vitamin E 5.0718709164
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D013272 Stomach Diseases Indomethacin 4.5018209964 10486359 10192188 10215738 16113693 15472012 18545984 17160473 16280098 17207306 17638125 15038085 16184426
MESH:D013274 Stomach Neoplasms Indomethacin 2.8615609394
MESH:D013274 Stomach Neoplasms irinotecan 2.8615723263
MESH:D013276 Stomach Ulcer Indomethacin 3.6418431645 11595431 15104355 11595415 17627676 18087811 10750652 18209962 15138204 18237397 16397915 18726076 16755016 11145282 15255614 12467913 16252198 14567935 12077510 16934674 12500499 12498302 10423059 18181030 16169175 18299717 11906479 11729361 17977527 17654042 17657623 11523592 1323529 16150113 12787963 10878458 17135157 17895592 18193104 16631530 17918041 18543354
MESH:D020521 Stroke Vitamin E 3.5616517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013964 Thyroid Neoplasms Indomethacin 3.6211352223 14736730 18791128
MESH:D014456 Ulcer Indomethacin 4.9817380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.0816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.0816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.2710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.2710091137
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5915869587 14671159
MESH:D014839 Vomiting Indomethacin 4.8411897121
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00445 antagonist Epirubicin Antineoplastic Agents;Antibiotics, Antineoplastic
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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