AutismKB 2.0

Annotation Detail for CHD2


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Basic Information Top
Gene Symbol:CHD2 ( DKFZp547I1315,DKFZp686E01200,DKFZp781D1727,FLJ38614 )
Gene Full Name: chromodomain helicase DNA binding protein 2
Band: 15q26.1
Quick LinksEntrez ID:1106; OMIM: 602119; Uniprot ID:CHD2_HUMAN; ENSEMBL ID: ENSG00000173575; HGNC ID: 1917
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of CHD2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CHD2 mRNAaffects expression 17562736
D001151 Arsenic Arsenic affects the expression of CHD2 mRNAaffects expression 18414638
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of CHD2 mRNAincreases expression 18687144
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CHD2 mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in increased expression of CHD2 mRNAincreases expression 20106945
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of CHD2 mRNAaffects cotreatment|increases expression 17183730
D010634 Phenobarbital Phenobarbital results in decreased expression of CHD2 mRNAdecreases expression 19270015
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of CHD2 mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid Valproic Acid results in decreased expression of CHD2 mRNAdecreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of CHD2 mRNAaffects expression 19015723
C025643 vinclozolin vinclozolin results in decreased expression of CHD2 mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 15.797525203
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 15.796195326
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 15.798875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.2117620307
MESH:D018246 Adrenocortical Adenoma Arsenic 5.4817306315
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001008 Anxiety Disorders Valproic Acid 9.3217497229
MESH:D001008 Anxiety Disorders vinclozolin 9.3219015723
MESH:D020261 Arsenic Poisoning Arsenic 2.9112569548 16251483 18414634 16835338
MESH:D050197 Atherosclerosis Arsenic 3.3419371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8620603192 18940202 17507914 18177632 18316065 17688650 15238991 17157402 18985861 19232924 18396377 19460635 16609825 18775368 18558336
MESH:D001714 Bipolar Disorder Valproic Acid 3.1517594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.518888407
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6815504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.733084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.7317306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.7320935162 20007298 6705139 17173139 1701930
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7315504454 18922899 17687452
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2418640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.5615738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.4618022660 16973168
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.7414694615
MESH:D002386 Cataract Acetaminophen 7.7410977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9412371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.474080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.3115095906
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 17688650 16575769
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.5521346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5512392966 16081117 17562736 10915739 11529661 19739265 11743745 11287661 12153990 16109766 12705907 17522070 11461765 11421492 18071297 15968718 11739529 17906064 16781746 14986274 16393943 12958197 16485898 19085960 19370779 15619225 19416960 19420014 14725611 2444490 18713872 11834606 10663392 16177239 14550746 16227642 12540782 19923254 10774834 19164858 12594235
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.551733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004421 Dystonia Phenobarbital 11.061851702
MESH:D004421 Dystonia Valproic Acid 11.061851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 11.523659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 11.523659116 17275665
MESH:D004828 Epilepsies, Partial Phenobarbital 10.8811558140 3922381
MESH:D004828 Epilepsies, Partial Valproic Acid 10.8816628512 3922381
MESH:D004827 Epilepsy Phenobarbital 6.9320417680
MESH:D004827 Epilepsy Valproic Acid 6.9320417680 18234410
MESH:D004832 Epilepsy, Absence Phenobarbital 9.386401628
MESH:D004832 Epilepsy, Absence Valproic Acid 9.387562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 12.037750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 12.037750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 11.293659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 11.293659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005234 Fatty Liver Cyclosporine 8.3319224547
MESH:D005234 Fatty Liver Valproic Acid 8.3319224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.338888407 18558336
MESH:D005355 Fibrosis Cyclosporine 3.3612168785 12639820
MESH:D005534 Foot Diseases Arsenic 5.826392382
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006529 Hepatomegaly Phenobarbital 3.7016109766
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6217050553
MESH:D006973 Hypertension Arsenic 5.499931084 11953799 16076760
MESH:D006973 Hypertension Cyclosporine 5.4910903974
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8416612254
MESH:D006987 Hypesthesia Arsenic 5.8216093927
MESH:D007248 Infertility, Male vinclozolin 3.1516467254
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007642 Keratosis Arsenic 5.2312749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 6.1015629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.1010903974 18776723 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8812371664
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6617339181
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9821047994
MESH:D008107 Liver Diseases Acetaminophen 6.7811587558 19014921 19460945 19784758 16610002 16611625 12587719 12969438
MESH:D008107 Liver Diseases Arsenic 6.7811134558
MESH:D008107 Liver Diseases Phenobarbital 6.7819363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms Arsenic 4.9716368122
MESH:D008113 Liver Neoplasms Phenobarbital 4.978742319 15975961 21047994 19482888 19812893 19073162
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.8017172636 18308698 2563599 6150874 1399818
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.2417365036
MESH:D008175 Lung Neoplasms Arsenic 2.2019168569 17976673 17306315
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2418303189 16166281 16966607
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D008881 Migraine Disorders Valproic Acid 3.3118765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2417596541
MESH:D017202 Myocardial Ischemia Arsenic 4.1215371236
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7117484760
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009436 Neural Tube Defects Arsenic 7.8116620997
MESH:D009436 Neural Tube Defects Valproic Acid 7.8116359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.5617056641
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 4.2614694615
MESH:D010018 Osteomalacia Phenobarbital 4.6017016548
MESH:D010051 Ovarian Neoplasms Arsenic 2.7917306315
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5416965848
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3816093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.236392382 16905509 15371236
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.1110923243
MESH:D011230 Precancerous Conditions Cyclosporine 9.4812371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.482563599
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.5320603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.5319015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D011471 Prostatic Neoplasms Arsenic 3.5816140617
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D011507 Proteinuria Arsenic 4.1921343184
MESH:D019310 Pseudolymphoma Phenobarbital 13.0912752131
MESH:D019310 Pseudolymphoma Valproic Acid 13.0911422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0817365031 15814490 17975199 17322281
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Phenobarbital 6.384039156 3137016 16876388 11442880
MESH:D012640 Seizures Valproic Acid 6.3811738929 16876388 17978042 15475178 14763951 11044598 1511512 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 5.066407741
MESH:D012871 Skin Diseases Arsenic 2.7819834688 16353154 18709164 17938729 15952646 17453740 17050553 6392382 16702368 16759981 17548696
MESH:D012878 Skin Neoplasms Arsenic 3.0819538983 17029826 15504454 17976673 16251483 17050553
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.181399818
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.8711144890 18640142 19322015 15987713 17976673 19429237 17306315
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014652 Vascular Diseases Arsenic 4.9717056641
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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