AutismKB 2.0

Annotation Detail for WWP2


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Basic Information Top
Gene Symbol:WWP2 ( AIP2,WWp2-like )
Gene Full Name: WW domain containing E3 ubiquitin protein ligase 2
Band: 16q22.1
Quick LinksEntrez ID:11060; OMIM: 602308; Uniprot ID:WWP2_HUMAN; ENSEMBL ID: ENSG00000198373; HGNC ID: 16804
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04120Ubiquitin mediated proteolysis
No data
No data
Pathway IDPathway Name
P00060Ubiquitin proteasome pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2118Adenovirus infection
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of WWP2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of WWP2 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of WWP2 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of WWP2 mRNAincreases expression 19638242
D015025 Zearalenone Zearalenone results in decreased expression of WWP2 mRNAdecreases expression 19371625
C059514 resveratrol resveratrol results in decreased expression of WWP2 mRNAdecreases expression 19371625
D012645 Selenomethionine Selenomethionine affects the expression of WWP2 mRNAaffects expression 17222674
C004648 testosterone enanthate testosterone enanthate affects the expression of WWP2 mRNAaffects expression 17440010
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury resveratrol 4.0916538975
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0320127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 11.966695378
MESH:D000236 Adenoma Diethylnitrosamine 11.966695378 10737359
MESH:D000236 Adenoma resveratrol 11.9615688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.2418056438 16434500 17162532 17620307 19061943 19052882
MESH:D000544 Alzheimer Disease resveratrol 2.6116183991 16162502
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001169 Arthritis, Experimental resveratrol 3.6417115116
MESH:D050197 Atherosclerosis resveratrol 3.4016873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D002545 Brain Ischemia resveratrol 4.6217600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9320146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9317474063
MESH:D001943 Breast Neoplasms resveratrol 1.9316393696 17651959 17534123
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.843084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.8417173139 20214788 19519916 20514400 16288022 18788625 19822196 16569478 20084675 19919837 19335982 19208518 17761372 16698587 16807293 18665156 20007298 18971187 16779866 19418558 20935162 16878318 17428255 20101231 18785209 17162532 19171122 16502159 17138121 16540662 11831363 19052882 3581430 18506893 21159647 18056438 20524982 19107877 19394651 19539802 17978847 18210153 17055752 16935385 3084413 18393292 16681979 20512989 18494052 19383236 18978308 10672840 19701751 18691550 16830150 20727157 10737359 16328049 20432363
MESH:D006528 Carcinoma, Hepatocellular resveratrol 6.8416227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.9316675471
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.9220419170
MESH:D002294 Carcinoma, Squamous Cell resveratrol 4.9216227395
MESH:D002318 Cardiovascular Diseases resveratrol 3.6315458977
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.0117174075 2727394 7505956 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D003092 Colitis resveratrol 4.4316474422
MESH:D003110 Colonic Neoplasms resveratrol 2.4916338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D003327 Coronary Disease resveratrol 3.8916507316
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3218551238
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.9716873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D003928 Diabetic Nephropathies resveratrol 4.1816286809
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5416177239 10915739 16109766 11743745 14986274 2444490 11834606 16393943 19085960 12153990 17522070 19416960 16227642 17906064 19420014 11287661 10774834 14725611 12392966 16485898 11421492 14550746 15968718 12705907 16081117 19739265 15619225 19164858 12958197 11461765 12540782 10663392 17562736 16781746 18071297 11529661 12594235 18713872 19370779 11739529 19923254
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.5419107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004487 Edema resveratrol 3.608985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.3117872969
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.1617923197
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005234 Fatty Liver Diethylnitrosamine 3.4320387270 21071580
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7720471113
MESH:D006561 Herpes Simplex resveratrol 4.5216876885
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.1217440010
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006937 Hypercholesterolemia resveratrol 4.2517188708
MESH:D006949 Hyperlipidemias resveratrol 4.2916873680
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.5317488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.9517600658
MESH:D007249 Inflammation Diethylnitrosamine 5.6318785209
MESH:D007249 Inflammation resveratrol 5.6316366677
MESH:D007251 Influenza, Human resveratrol 4.9216624496
MESH:D007674 Kidney Diseases Acetaminophen 2.3215629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.1716705839
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.7216087638
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9418407596 20032147 18522880 18665156 19638242
MESH:D008107 Liver Diseases Acetaminophen 4.0819460945 12969438 19014921 12587719 11587558 19784758 16611625 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0817034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.9620195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.9619812893 19255062 12771043 20434301 21047994 20118626 16942905 19690152 20137499 18978307 19833225 19642983 20405173 19638242 19499222 19850985 12112319 19551842 10737359 21071580 9163691 19996281 20452335 15175105 20492335 20583210 19256749 18977376 19073162 21278145 20501860 19426721 18644402 19254457 2862719 15885732 18648771 21167192 2422723 20101389 19090486 18754104 19427195 19294768
MESH:D008113 Liver Neoplasms resveratrol 7.9620405173 19073162 19812893 19321006
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7718079962 18164116 18775883 16267830 18544905 18282651 17942915 19009564 18093689 19539802 3124819 18253720 19126423 9362446 17854601 19519916 19004024 18308698 2563599 17174075 16842330 21159647
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4320464547 18520028 17053015 18816296 20064080 6695378 18569708 20135361 20869020
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.4320970405 20512841 21163286 6695378
MESH:D016393 Lymphoma, B-Cell resveratrol 4.5617088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.0714749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.5815688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.2511606380 8985016
MESH:D008545 Melanoma resveratrol 2.3917992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008659 Metabolic Diseases resveratrol 4.6217112576
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009101 Multiple Myeloma resveratrol 3.6314749477 16267019 17049120 17935668 16490592 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.2117962980
MESH:D009203 Myocardial Infarction resveratrol 3.1116317513 17015251 16456233 17125593 16525036 17188708
MESH:D017202 Myocardial Ischemia resveratrol 4.2017125593 17015251
MESH:D009205 Myocarditis resveratrol 5.1017322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2018551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.653581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2711141357
MESH:D009374 Neoplasms, Experimental resveratrol 4.318985016
MESH:D019636 Neurodegenerative Diseases Acetaminophen 15.2718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 15.2720387270
MESH:D019636 Neurodegenerative Diseases resveratrol 15.2717652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.6617929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6616049721 12819281
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.5217513867
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4916540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.772563599
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 4.5216679765
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2617292933
MESH:D011471 Prostatic Neoplasms resveratrol 3.2616731767 17636462 17675339 17804756 15767336 17718901
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.9616325855
MESH:D015427 Reperfusion Injury resveratrol 3.3716317513 16314181 17058453 17520802 15827377
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6818551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.1710029692 19755658
MESH:D012878 Skin Neoplasms resveratrol 6.178985016 15837718
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.382093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3818456281
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.7116321402
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.167505956
MESH:D014062 Tongue Neoplasms resveratrol 4.4416227395
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2417053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6510091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.3317473185
MESH:D014594 Uterine Neoplasms resveratrol 4.4217044934
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.6117488730
Pathway ID Pathway Name
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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