AutismKB 2.0

Annotation Detail for RAPGEF4


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Basic Information Top
Gene Symbol:RAPGEF4 ( CAMP-GEFII,CGEF2,EPAC2,Nbla00496 )
Gene Full Name: Rap guanine nucleotide exchange factor (GEF) 4
Band: 2q31.1
Quick LinksEntrez ID:11069; OMIM: 606058; Uniprot ID:RPGF4_HUMAN; ENSEMBL ID: ENSG00000091428; HGNC ID: 16626
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
Related Diseases/Disorders Top
Desease IDDesease Name
2124Autistic disorder
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C518576 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate results in decreased expression of RAPGEF4 mRNAdecreases expression 17327690
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of RAPGEF4 proteinaffects expression 20106945
C432165 anthra(1,9-cd)pyrazol-6(2H)-one anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Ozone results in increased expression of RAPGEF4 mRNA]decreases reaction|increases expression 17460151
C006632 arsenic trioxide arsenic trioxide results in increased expression of RAPGEF4 mRNAincreases expression 15761015
D001554 Benzene Benzene results in decreased expression of RAPGEF4 proteindecreases expression 15468289
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RAPGEF4 mRNAdecreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RAPGEF4 mRNAaffects expression 12734012
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RAPGEF4 mRNAaffects cotreatment|affects expression 17602206
D003010 Clorgyline Clorgyline results in increased expression of RAPGEF4 mRNAincreases expression 19691856
D003024 Clozapine Clozapine results in decreased expression of RAPGEF4 mRNAdecreases expression 18797397
D003345 Corticosterone Corticosterone results in increased expression of RAPGEF4 mRNAincreases expression 15755911
D016572 Cyclosporine Cyclosporine results in decreased expression of RAPGEF4 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RAPGEF4 mRNAaffects cotreatment|affects expression 17602206
D004958 Estradiol Estradiol results in decreased expression of RAPGEF4 mRNAdecreases expression 20106945
D006220 Haloperidol Haloperidol results in decreased expression of RAPGEF4 mRNAdecreases expression 18797397
C008493 methylselenic acid methylselenic acid results in increased expression of RAPGEF4 mRNAincreases expression 12517777
D009151 Mustard Gas Mustard Gas results in decreased expression of RAPGEF4 mRNAdecreases expression 18988085
C076029 olanzapine olanzapine results in decreased expression of RAPGEF4 mRNAdecreases expression 18797397
D010126 Ozone anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Ozone results in increased expression of RAPGEF4 mRNA]decreases reaction|increases expression 17460151
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of RAPGEF4 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of RAPGEF4 mRNAincreases expression 19482888
19270015
D010656 Phenylephrine Phenylephrine results in increased expression of RAPGEF4 mRNAincreases expression 18158353
C006253 pirinixic acid pirinixic acid results in increased expression of RAPGEF4 mRNAincreases expression 18445702
D011189 Potassium Chloride Potassium Chloride results in decreased expression of RAPGEF4 mRNAdecreases expression 16412482
D012402 Rotenone Rotenone results in increased expression of RAPGEF4 mRNAincreases expression 19013527
C009250 sevoflurane sevoflurane affects the expression of RAPGEF4 mRNAaffects expression 15967596
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RAPGEF4 mRNAdecreases expression 20106945
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134861108
  • Releated disease ID Related disease Name
    PA446714Neoplasm, Residual
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018