AutismKB 2.0

Annotation Detail for RAPGEF4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RAPGEF4 ( CAMP-GEFII,CGEF2,EPAC2,Nbla00496 )
Gene Full Name: Rap guanine nucleotide exchange factor (GEF) 4
Band: 2q31.1
Quick LinksEntrez ID:11069; OMIM: 606058; Uniprot ID:RPGF4_HUMAN; ENSEMBL ID: ENSG00000091428; HGNC ID: 16626
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
Pathway IDPathway Name
Diabetes pathways
Hemostasis
Signaling in Immune system
Integration of energy metabolism
Integrin cell surface interactions
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2124Autistic disorder
No data
Desease Name
Longevity
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C518576 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate results in decreased expression of RAPGEF4 mRNAdecreases expression 17327690
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of RAPGEF4 proteinaffects expression 20106945
C432165 anthra(1,9-cd)pyrazol-6(2H)-one anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Ozone results in increased expression of RAPGEF4 mRNA]decreases reaction|increases expression 17460151
C006632 arsenic trioxide arsenic trioxide results in increased expression of RAPGEF4 mRNAincreases expression 15761015
D001554 Benzene Benzene results in decreased expression of RAPGEF4 proteindecreases expression 15468289
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RAPGEF4 mRNAdecreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RAPGEF4 mRNAaffects expression 12734012
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RAPGEF4 mRNAaffects cotreatment|affects expression 17602206
D003010 Clorgyline Clorgyline results in increased expression of RAPGEF4 mRNAincreases expression 19691856
D003024 Clozapine Clozapine results in decreased expression of RAPGEF4 mRNAdecreases expression 18797397
D003345 Corticosterone Corticosterone results in increased expression of RAPGEF4 mRNAincreases expression 15755911
D016572 Cyclosporine Cyclosporine results in decreased expression of RAPGEF4 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RAPGEF4 mRNAaffects cotreatment|affects expression 17602206
D004958 Estradiol Estradiol results in decreased expression of RAPGEF4 mRNAdecreases expression 20106945
D006220 Haloperidol Haloperidol results in decreased expression of RAPGEF4 mRNAdecreases expression 18797397
C008493 methylselenic acid methylselenic acid results in increased expression of RAPGEF4 mRNAincreases expression 12517777
D009151 Mustard Gas Mustard Gas results in decreased expression of RAPGEF4 mRNAdecreases expression 18988085
C076029 olanzapine olanzapine results in decreased expression of RAPGEF4 mRNAdecreases expression 18797397
D010126 Ozone anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Ozone results in increased expression of RAPGEF4 mRNA]decreases reaction|increases expression 17460151
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of RAPGEF4 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of RAPGEF4 mRNAincreases expression 19482888
19270015
D010656 Phenylephrine Phenylephrine results in increased expression of RAPGEF4 mRNAincreases expression 18158353
C006253 pirinixic acid pirinixic acid results in increased expression of RAPGEF4 mRNAincreases expression 18445702
D011189 Potassium Chloride Potassium Chloride results in decreased expression of RAPGEF4 mRNAdecreases expression 16412482
D012402 Rotenone Rotenone results in increased expression of RAPGEF4 mRNAincreases expression 19013527
C009250 sevoflurane sevoflurane affects the expression of RAPGEF4 mRNAaffects expression 15967596
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RAPGEF4 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.596195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.5915322242 11752688 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 2.9218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.7419825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.7420464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 6.7411473722
MESH:D000236 Adenoma Benzo(a)pyrene 6.236695378
MESH:D000236 Adenoma Diethylnitrosamine 6.236695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 23.1219061943 18056438 17620307 19052882 17162532 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 23.1217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 23.1216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 23.1216835633
MESH:D000380 Agranulocytosis Clozapine 4.8516160616 14617031 12649775
MESH:D000544 Alzheimer Disease Ozone 2.3915513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D000741 Anemia, Aplastic Benzene 4.2114761424 17661222 11369114
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8719183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.9317460149
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5115570426
MESH:D001249 Asthma Mustard Gas 4.8710378619
MESH:D001249 Asthma Ozone 4.8717854713 16373670
MESH:D001321 Autistic Disorder Haloperidol 2.8419368416 18080171
MESH:D001321 Autistic Disorder olanzapine 2.8418685284 17069543
MESH:D001768 Blister Mustard Gas 4.9519167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.1816206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.1819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D001855 Bone Marrow Diseases Benzene 5.0216183116
MESH:D001919 Bradycardia Phenylephrine 4.3315306635
MESH:D001943 Breast Neoplasms Benzene 2.2617162533 11921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2620146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2617474063
MESH:D001943 Breast Neoplasms Estradiol 2.2617261762 16675129 18497071 12948864 14630087 17289903 17018787 19861407
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2620435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5115516495 16777450 18417511 14754758 17626835 18315731 19059883
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7617687719 10378619
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1311589617
MESH:D002100 Cachexia Ozone 4.5316183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2516111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5716097048 15721981 18705752 16050911 10355542 16192424 3786805 15673190 16011737 16227642 16124888 15700767
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6316835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.5512907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular anthra(1,9-cd)pyrazol-6(2H)-one 13.5519418558
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.5515553829 15073043 16217749 11135700 14691202
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.5518788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.5518788625 16569478 18665156 20727157 3581430 16935385 19335982 18506893 21159647 16328049 19394651 3084413 19822196 20214788 17055752 18393292 19383236 17428255 20101231 16288022 16779866 20935162 19519916 17761372 18978308 19208518 20512989 19171122 16878318 18210153 20514400 16502159 18056438 19052882 19107877 17138121 17162532 19701751 20432363 17978847 10737359 20524982 16681979 11831363 16807293 19539802 19418558 17173139 18785209 16830150 20007298 10672840 18691550 18971187 16540662 16698587 18494052 20084675 19919837
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.5516924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.556705139 20007298 20935162 1701930 17173139
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6619014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9312490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 1.9920419170
MESH:D006332 Cardiomegaly Phenylephrine 6.5015728586 11754973 17124262 11179087 16170337 17287366
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.5018670907 16120746 18850075
MESH:D002375 Catalepsy Haloperidol 4.701977408 15215559
MESH:D002389 Catatonia olanzapine 6.0416772815 18071103
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.3312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.3317174075 7505956 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.3318566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.044080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D002779 Cholestasis Cyclosporine 7.2519486331
MESH:D002779 Cholestasis pirinixic acid 7.2519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0216354765 12621046 8697196 15668235 15340226
MESH:D003072 Cognition Disorders Clozapine 4.7617123785
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8814669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7110525206
MESH:D019465 Craniofacial Abnormalities Benzene 3.7115643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7115322242 10048152 20055451
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 10.2715213294
MESH:D016757 Death, Sudden, Cardiac Haloperidol 10.2720210726
MESH:D003704 Dementia Haloperidol 4.3911575062
MESH:D003872 Dermatitis Benzene 4.5615902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3318249437
MESH:D002658 Developmental Disabilities olanzapine 4.5517069543
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 6.8616402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.8620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8617107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2419279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.3415331141
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.8216227642 15998439 15968718 21278145 16177239 15027814 2869522 6623471 10915739 7120509 19336974 3732212 11566570 7179309 19085960 6884620 4309450 3786805 7440962 10092053 17522070 9327722
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.8219107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.8220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6111462148
MESH:D050171 Dyslipidemias Clozapine 4.0316402076
MESH:D004421 Dystonia Phenobarbital 3.811851702
MESH:D004487 Edema Mustard Gas 10.3411428631 9260866 11402378 11428647
MESH:D004487 Edema pirinixic acid 10.3412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.3412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6918230668 16714409 15322242
MESH:D016889 Endometrial Neoplasms Estradiol 2.8519148513 11473722 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.849294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.903659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.663922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.376401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.047750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.813659116
MESH:D004890 Erythema Mustard Gas 4.959357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9016302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.2512903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2516530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8611564622
MESH:D005234 Fatty Liver arsenic trioxide 22.6315073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 22.6316045604 16239168 61145 15959796 17595544 12631006 12795759 19224547
MESH:D005234 Fatty Liver Cyclosporine 22.6319224547
MESH:D005234 Fatty Liver Diethylnitrosamine 22.6320387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 22.6319236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D005355 Fibrosis Carbon Tetrachloride 13.5118705752
MESH:D005355 Fibrosis Cyclosporine 13.5112168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.5120067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0616904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.018708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.0820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.0810048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4120558911
MESH:D006402 Hematologic Diseases Benzene 4.4616183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3919900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 13.1816109766
MESH:D006529 Hepatomegaly pirinixic acid 13.1819772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.1815340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8215709030
MESH:D019584 Hot Flashes Estradiol 3.5417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.838697196 18606429 15340226 16354765 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3216899240
MESH:D006943 Hyperglycemia pirinixic acid 3.0020558911
MESH:D006948 Hyperkinesis Clozapine 4.7016046005
MESH:D006963 Hyperphagia olanzapine 6.0217933447
MESH:D006973 Hypertension Benzene 11.7417940673
MESH:D006973 Hypertension Cyclosporine 11.7410903974
MESH:D006973 Hypertension Phenylephrine 11.7412717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.7418670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8815338365
MESH:D006984 Hypertrophy Phenylephrine 4.3612791704 18502941
MESH:D007249 Inflammation Diethylnitrosamine 7.6918785209
MESH:D007249 Inflammation Mustard Gas 7.699260866 17524151 11428647 11428631 11402378 9357497 11428620 8975870 16001271
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.6912878042 12200463
MESH:D007333 Insulin Resistance Estradiol 6.7516627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.7516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1516580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2315604871
MESH:D007674 Kidney Diseases Cyclosporine 5.548314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 5.5415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 6.7112371664
MESH:D007680 Kidney Neoplasms Estradiol 6.7115610895
MESH:D007859 Learning Disorders sevoflurane 4.5719212262
MESH:D007938 Leukemia arsenic trioxide 6.2215070760
MESH:D007938 Leukemia Benzene 6.2218335105 14694614 15935818 17119257
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6112560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute anthra(1,9-cd)pyrazol-6(2H)-one 11.0716972261
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 11.0716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2714633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.0719077051
MESH:D007951 Leukemia, Myeloid Benzene 9.0717506065
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9817050201 16968895 20471514 16467208 19850784
MESH:D015470 Leukemia, Myeloid, Acute Benzene 3.9819478238
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.0812679006 12018890 12712474 16966277 19075265 15336539 15213294 19642359 16891316 17217047 17712046 17107899 17869043 16331271 17649720 15748426 11468182 16330433 15622746 11161223 16823087 19225113 16112521 19035177 9834237
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1516882451
MESH:D008064 Lipidoses Clozapine 3.8117567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.3521278145 11903743 11408273 16221502 16239168 17157831 17334410 16943688 17174718
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.3518407596 20032147 18665156 18522880 19638242
MESH:D008103 Liver Cirrhosis Phenobarbital 10.3521047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.7015996030 14716496 17557913 15931870 18156304 17714472 12445421 15893842 17565644 17708605 18339082 17823541 18279442 17698563 17944888 18251166 18317297 17869086 18210741 18277467 17766677 14748882 12632512 18472332 16192424 17922224 17631135 16011737 16116963 17976157 18705752 14512876 15057751 18472094 12546737 15370692 11481614 18263696 15362042 15959796 15123356 15052691 16027843 14620537 18412020 12445418 17805973 12649538 15876570 16015684 15673190 15925388 17525996 15650968 18166357 18376398 15730626 16638106 18481824 17481882 16033810 12666154 18420326 16136751 17721639 15818738 16248980 18054572 17640975 12389079 14724832 17761835 16097048 18006644 18187930 12898905 12741479 12586293 15338365 14716833 12609069 18205269 18395914 18395095 13678700 18429990 17900296 18418968 12632514 20821823 12667390 10355542 12958196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.7014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.7015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7012878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.2215830285 16964402 16246199 15720792 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 6.2217034775
MESH:D008107 Liver Diseases Phenobarbital 6.2219363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9615123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5116899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 28.619163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms arsenic trioxide 28.6114682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 28.6121137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 28.6119294768
MESH:D008113 Liver Neoplasms Clofibric Acid 28.6117602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 28.6119690152 19551842 20137499 15885732 19426721 20405173 19256749 19090486 18754104 18978307 18648771 2862719 19638242 19427195 12771043 2422723 20101389 15175105 19499222 20492335 9163691 10737359 21278145 20501860 20452335 20118626 19812893 21047994 12112319 21071580 19294768 19833225 19254457 19996281 18644402 19850985 18977376 19255062 16942905 21167192 19642983 20434301 20583210 19073162
MESH:D008113 Liver Neoplasms Phenobarbital 28.6115975961 21047994 19482888 19073162 19812893 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 28.6120007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 28.6116984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 26.298603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 26.2920377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 26.2912562636
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 26.2915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 26.2918079962 16267830 18164116 18282651 18544905 17174075 18253720 2563599 18775883 16842330 9362446 21159647 19126423 3124819 18093689 19004024 19519916 19539802 18308698 17854601 19009564 17942915
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 26.2918308698 1399818 6150874 2563599 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 26.2912151625
MESH:D008133 Long QT Syndrome arsenic trioxide 8.0915213294
MESH:D008133 Long QT Syndrome olanzapine 8.0920210726
MESH:D008171 Lung Diseases Mustard Gas 7.1518161513 18702808
MESH:D008171 Lung Diseases Ozone 7.158266340 19066396
MESH:D017563 Lung Diseases, Interstitial Benzene 4.6014698565
MESH:D055370 Lung Injury Ozone 3.6420417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 12.5314755239
MESH:D008175 Lung Neoplasms arsenic trioxide 12.5311798837 19825857
MESH:D008175 Lung Neoplasms Benzene 12.5312562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 12.536695378 20869020 18569708 17053015 18816296 20064080 20464547 18520028 20135361
MESH:D008175 Lung Neoplasms Diethylnitrosamine 12.5320970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Mustard Gas 12.538781369 3148597
MESH:D008175 Lung Neoplasms Ozone 12.538597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.5319555203 11884234
MESH:D008223 Lymphoma Benzene 3.5917119257 17584886
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.2312562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 9.3911921183
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 9.3912807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.3911408345 16891317 17203775 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.2719453300
MESH:D008569 Memory Disorders sevoflurane 4.5519212262
MESH:D001523 Mental Disorders Clozapine 12.2316856516
MESH:D001523 Mental Disorders Haloperidol 12.2316856516
MESH:D001523 Mental Disorders olanzapine 12.2316856516
MESH:D008659 Metabolic Diseases olanzapine 5.2019142110
MESH:D024821 Metabolic Syndrome X Clozapine 4.2419142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5816801185
MESH:D008679 Metaplasia Ozone 4.8910496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0316381670
MESH:D009101 Multiple Myeloma arsenic trioxide 7.0019417148 14977855 15949261 11468182 19549372
MESH:D009101 Multiple Myeloma Benzene 7.0017119195
MESH:D009135 Muscular Diseases pirinixic acid 3.3016239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0216105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.0619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.7216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.7216411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2617484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7616624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.483581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 4.4811141357
MESH:D009369 Neoplasms pirinixic acid 4.4817405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1118481113 19348381
MESH:D009410 Nerve Degeneration Rotenone 3.7218619942 17356569 15790535
MESH:D009421 Nervous System Malformations Estradiol 8.7916427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.7914600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.0810525206
MESH:D009436 Neural Tube Defects Benzene 7.0815643154
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9020387270
MESH:D009503 Neutropenia Mustard Gas 3.7816761898 7688884
MESH:D009765 Obesity Clozapine 7.3519142110 18515891
MESH:D009765 Obesity olanzapine 7.3518515891
MESH:D009765 Obesity pirinixic acid 7.3520558911
MESH:D009784 Occupational Diseases Benzene 4.0015576619 16737584 15612468 17479406 17119257 15727169 17178637 15913788 15935809
MESH:D010018 Osteomalacia Phenobarbital 4.1517016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.5616624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Benzene 7.5612562636
MESH:D010051 Ovarian Neoplasms Estradiol 7.5619401270
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.1715580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.1716540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.1716965848
MESH:D010235 Paraganglioma arsenic trioxide 3.9719927285
MESH:D010300 Parkinson Disease Rotenone 2.9016412576 15451049 16140633 18619942 18191903 11445065 19114014 11535288 19232380
MESH:D020734 Parkinsonian Disorders Rotenone 3.8915795934 15927086 18197244 15574749
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D010538 Peritonitis Ozone 3.9216369182
MESH:D011014 Pneumonia Ozone 4.1818381685 18007984 18929643
MESH:D011041 Poisoning Mustard Gas 3.6015727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.2512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.252563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.252563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9811118676 11896295 11222880 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6920887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.9019131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9017292933
MESH:D011471 Prostatic Neoplasms Clorgyline 1.9019691856
MESH:D011471 Prostatic Neoplasms Estradiol 1.9016740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 1.9016205645
MESH:D011537 Pruritus Mustard Gas 3.8818058305
MESH:D019310 Pseudolymphoma Phenobarbital 4.2812752131
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011595 Psychomotor Agitation Haloperidol 11.1211575062
MESH:D011595 Psychomotor Agitation olanzapine 11.1218685284
MESH:D011618 Psychotic Disorders Clozapine 8.6615331141
MESH:D011618 Psychotic Disorders Haloperidol 8.6611575062
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8517266442 17894541 10334151 17620002 17720292
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7616646077
MESH:D012559 Schizophrenia Clozapine 5.7020168265 11151749 11763009 20452607 20107430 18806925 17667964 17123785 17726453 20521326 20580759 20521320 18855531 16141801 19369910
MESH:D012559 Schizophrenia Haloperidol 5.701830565 20107430 19369910 18513383
MESH:D012559 Schizophrenia olanzapine 5.7020107430 20521326 17726453
MESH:D012640 Seizures Phenobarbital 2.5611442880 4039156 3137016 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.616407741
MESH:D012852 Sinusitis Phenylephrine 4.497327846
MESH:D012871 Skin Diseases Mustard Gas 2.6612880345 15451306 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.1510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.1516192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.5617007042
MESH:D013274 Stomach Neoplasms Benzene 4.5612562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.562093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.5618456281
MESH:D017180 Tachycardia, Ventricular Haloperidol 10.2820210726
MESH:D017180 Tachycardia, Ventricular olanzapine 10.2820210726
MESH:D013953 Thymus Neoplasms Benzene 4.7410850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.0619014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.067505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 11.061399818
MESH:D013978 Tibial Fractures Estradiol 4.4719048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7515213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 4.7720435036 12845720 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.7717053015
MESH:D014594 Uterine Neoplasms Benzene 4.1312562636
MESH:D014605 Uveitis Cyclosporine 3.771336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D015430 Weight Gain Clozapine 9.7616402076 20107430 20521320 17502770 20564506 16141801
MESH:D015430 Weight Gain olanzapine 9.7619434072 17933447 20107430
MESH:D015431 Weight Loss Clozapine 4.8717933447
MESH:D014985 Xerophthalmia Cyclosporine 4.2317120751
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
REACT:604 Hemostasis
REACT:1505 Integration of energy metabolism
REACT:13552 Integrin cell surface interactions
KEGG:04670 Leukocyte transendothelial migration
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134861108
    • No data
    Releated disease ID Related disease Name
    PA446714Neoplasm, Residual
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA451718tolbutamide
    PA164749238exenatide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved