AutismKB 2.0

Annotation Detail for TMEM115


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Basic Information Top
Gene Symbol:TMEM115 ( PL6 )
Gene Full Name: transmembrane protein 115
Band: 3p21.31
Quick LinksEntrez ID:11070; OMIM: 607069; Uniprot ID:TM115_HUMAN; ENSEMBL ID: ENSG00000126062; HGNC ID: 30055
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TMEM115 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TMEM115 mRNAaffects expression 17562736
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TMEM115 mRNAaffects expression 17555576
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TMEM115 mRNAaffects binding|decreases expression|increases activity 19710929
D018038 Sodium Selenite Sodium Selenite results in increased expression of TMEM115 mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of TMEM115 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.0714745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8714692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001943 Breast Neoplasms Tamoxifen 2.1819487384 19244106 17049068 19084267 17440819 15668708 21138602 16273361 19200415 18984771 16873071 19066611 18425577 18629630 20390343 20135344 21152245 17242785 19410462 19189210 17261762 16202921 20544844 11161223 19221464 19155303 19115204 19142967 15565566 20065188 18815881 19103187 20859285 20005174 19288272 19189212 17893378 18855134 19289846 19059307 19011961 18821012 18351453 16818667 18997820
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9219066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.743084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7416924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9217572228
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002779 Cholestasis Ethinyl Estradiol 8.5216919318 11677210 17681005 17333356 16105132 15861022 17110522
MESH:D002779 Cholestasis pirinixic acid 8.5219176532
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1715894690
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.4318551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7819031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0616285004
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7619279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6712958197 10663392 15968718 18713872 19085960 11739529 11834606 12153990 19420014 17906064 10915739 18071297 16081117 12705907 11461765 11743745 19416960 12540782 16109766 11287661 17522070 14550746 12594235 11529661 19370779 14986274 14725611 2444490 12392966 16781746 17562736 10774834 16227642 19923254 19739265 19164858 16177239 11421492 15619225 16393943 16485898
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.6715131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.2412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.2419031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2419155303 17893378 16202921 20544844
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.0115345470
MESH:D005234 Fatty Liver pirinixic acid 15.0119236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 15.0119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4116709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.6419069698
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4119176532 18467677 19772884 16221962
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007249 Inflammation Tamoxifen 2.4919457130
MESH:D007333 Insulin Resistance pirinixic acid 7.9616306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.9614714311
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.2916705839
MESH:D007680 Kidney Neoplasms Tamoxifen 8.2918625569
MESH:D008064 Lipidoses Tamoxifen 3.3717567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.4018564211
MESH:D008107 Liver Diseases Acetaminophen 1.6916610002 16611625 11587558 19014921 12587719 12969438 19784758 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 4.7616377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 4.7616684651
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.4114737004
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8111731420 14580682 19196723 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 5.0719453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.6415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.3218551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.5219189210 19200415 19196722
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.7312819281 16049721
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.2218760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2215067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7715861022 16919318
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7318551238
MESH:D013088 Spermatocele Ethinyl Estradiol 13.3616709447
MESH:D013088 Spermatocele Tamoxifen 13.3616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5019457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3816049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.388653321 17572228 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8714671159 15869587
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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