AutismKB 2.0

Annotation Detail for DUSP14


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Basic Information Top
Gene Symbol:DUSP14 ( MKP-L,MKP6 )
Gene Full Name: dual specificity phosphatase 14
Band: 17q12
Quick LinksEntrez ID:11072; OMIM: 606618; Uniprot ID:DUS14_HUMAN; ENSEMBL ID: ENSG00000161326; HGNC ID: 17007
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
No data
No data
Pathway IDPathway Name
P00046Oxidative stress response
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C026137 3-hydroxyacetanilide 3-hydroxyacetanilide results in decreased expression of DUSP14 mRNAdecreases expression 18544908
D000082 Acetaminophen Acetaminophen results in increased expression of DUSP14 mRNAincreases expression 18544908
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DUSP14 proteinaffects expression 20106945
C015001 arsenite arsenite results in increased expression of DUSP14 mRNAincreases expression 18191166
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of DUSP14 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of DUSP14 mRNAincreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of DUSP14 mRNAincreases expression 17942748
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in increased expression of DUSP14 mRNA]affects reaction|increases expression 15016801
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of DUSP14increases expression 18687144
C041786 palm oil palm oil results in increased expression of DUSP14 mRNAincreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of DUSP14 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of DUSP14 mRNAincreases expression 19482888
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.636195326
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.2320127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.2314692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.2317638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.1617620307
MESH:D000740 Anemia Fluorouracil 3.8417963324 15504547 16511603
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001161 Arteriosclerosis Dietary Fats 10.5015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.5011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9117474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 1.9120435547
MESH:D001943 Breast Neoplasms Fluorouracil 1.9116595493 16557594 18357371 15136595 16110121 19217205 18608205
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8916051944
MESH:D002277 Carcinoma Fluorouracil 3.6817121937
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.743084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.7421507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.7417045692 17971768 16332177 17088986 18930000 16799960
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.741701930 20007298 6705139 17173139 20935162
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0718695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7620419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.7616757204 18986760 16280240 17066447
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.6116936243
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.434080065
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9817110522 16919318 17333356 16105132 11677210 17681005 15861022
MESH:D003110 Colonic Neoplasms arsenite 4.0415037631
MESH:D003110 Colonic Neoplasms Fluorouracil 4.0418772588 17169374 16510598 17172411 17725105 17287894 16340194 17016597 15001691 17018589
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018288408 17695437 14970324 16282729 17255274 18802399 15289873 18383874 16391804 16331619 17594712 16524972 18949393 20501625 18448328 18509181 17016601 16303861 15148649 17094418 17401013 17454858
MESH:D007644 Darier Disease Fluorouracil 4.9916733453
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6212392966 19923254 19420014 12153990 11421492 12540782 15619225 14550746 17522070 19370779 12958197 17562736 19416960 19164858 19085960 10774834 11461765 16485898 12705907 10663392 14986274 2444490 18071297 12594235 16109766 16393943 14725611 11529661 17906064 19739265 11743745 10915739 18713872 16081117 16177239 11739529 16781746 11834606 16227642 15968718 11287661
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5518367378
MESH:D004421 Dystonia Phenobarbital 4.151851702
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.283659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.093922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9520417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.676401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.437750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.213659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5916530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.5916785472 16337965 16481741 15173087 17638652
MESH:D005234 Fatty Liver arsenite 14.0218296743
MESH:D005234 Fatty Liver Dietary Fats 14.0219551842 19004024 17967931 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.0215345470
MESH:D005355 Fibrosis arsenite 9.6318296743
MESH:D005355 Fibrosis Dietary Fats 9.6318296743
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005910 Glioma Fluorouracil 2.9216145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4818337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7220471113
MESH:D006529 Hepatomegaly Phenobarbital 3.6616109766
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Dietary Fats 2.4920412841
MESH:D007333 Insulin Resistance Dietary Fats 3.1911836018 18457598
MESH:D007674 Kidney Diseases Acetaminophen 2.2715629191 12587719
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.4116518626
MESH:D007680 Kidney Neoplasms Fluorouracil 3.4216985049
MESH:D008103 Liver Cirrhosis arsenite 11.5318296743
MESH:D008103 Liver Cirrhosis Dietary Fats 11.5318296743
MESH:D008103 Liver Cirrhosis Phenobarbital 11.5321047994
MESH:D008107 Liver Diseases Acetaminophen 4.0412969438 16610002 16611625 19014921 12587719 19460945 11587558 19784758
MESH:D008107 Liver Diseases Phenobarbital 4.0419363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.1315890375 9163691 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1321137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 11.1317045692 15113037 18383874 16603448
MESH:D008113 Liver Neoplasms Phenobarbital 11.1321047994 19073162 19482888 15975961 19812893 8742319
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.308603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.302563599 17172636 6150874 1399818 18308698
MESH:D008175 Lung Neoplasms Aflatoxin B1 5.0114755239
MESH:D008175 Lung Neoplasms arsenite 5.0116809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0117053015 18816296 20869020 18569708 20064080 6695378 18520028 20135361 20464547
MESH:D008175 Lung Neoplasms Fluorouracil 5.0115246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9915086387
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.8916381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.8918986760 16757204
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6717484760
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2811141357
MESH:D009369 Neoplasms Fluorouracil 5.2818600527 18239605 16928823
MESH:D009389 Neovascularization, Pathologic arsenite 4.6115738583
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5316436463
MESH:D009765 Obesity Dietary Fats 2.3121332399 16723640 18674790 18457598 11836018 20518802 20132043 19632207 17217161
MESH:D010018 Osteomalacia Phenobarbital 4.5617016548
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.5019003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.5016965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010212 Papilloma Hydrogen Peroxide 4.2612065085
MESH:D011230 Precancerous Conditions Phenobarbital 3.752563599
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1917292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.1919082440 18626508
MESH:D011537 Pruritus Ethinyl Estradiol 3.5115861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.7112752131
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1418722050 18286688 15538739 16160472
MESH:D012640 Seizures Phenobarbital 2.7811442880 3137016 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.026407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.0519755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 6.0512065085
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4520155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4518567086 17522103 15786421 16424979 19015929 17498489 17172411 18396642 19084572 16951190
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.161399818
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1216280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2217053015
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0116803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D015430 Weight Gain Dietary Fats 3.8616723640
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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