AutismKB 2.0

Annotation Detail for TOPBP1


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Basic Information Top
Gene Symbol:TOPBP1 ( TOP2BP1 )
Gene Full Name: topoisomerase (DNA) II binding protein 1
Band: 3q22.1
Quick LinksEntrez ID:11073; OMIM: 607760; Uniprot ID:TOPB1_HUMAN; ENSEMBL ID: ENSG00000163781; HGNC ID: 17008
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
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Pathway IDPathway Name
200027E2F transcription factor network
200174BARD1 signaling events
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1944Breast cancer
2011Leukoencephalopathy
Desease Name
HEMATOLOGICAL
serum markers of iron status
Desease Name
Serum markers of iron status
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TOPBP1 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TOPBP1 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TOPBP1 mRNAdecreases expression 19150397
20382639
C099555 CD 437 CD 437 results in decreased expression of TOPBP1 mRNAdecreases expression 12958071
D016572 Cyclosporine Cyclosporine results in decreased expression of TOPBP1 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of TOPBP1 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TOPBP1 mRNA]decreases reaction|increases expression 17854601
D004958 Estradiol Estradiol affects the expression of TOPBP1 mRNAaffects expression 15598610
D005472 Fluorouracil TOPBP1 protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in decreased expression of TOPBP1 mRNAaffects cotreatment|decreases expression 17183730
C006253 pirinixic acid pirinixic acid results in increased expression of TOPBP1 mRNAincreases expression 18301758
C059514 resveratrol resveratrol results in decreased expression of TOPBP1 mRNAdecreases expression 15767336
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TOPBP1 mRNAincreases expression 19465110
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in decreased expression of TOPBP1 mRNAaffects cotreatment|decreases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.7015322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.708875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0119490988
MESH:D058186 Acute Kidney Injury resveratrol 3.9316538975
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.2020464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 7.2011473722
MESH:D000230 Adenocarcinoma Fluorouracil 7.2017638652
MESH:D000236 Adenoma Benzo(a)pyrene 11.476695378
MESH:D000236 Adenoma Diethylnitrosamine 11.4710737359 6695378
MESH:D000236 Adenoma resveratrol 11.4715688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.9917162532 16434500 17620307 19052882 18056438 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.9916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.9916835633
MESH:D000544 Alzheimer Disease resveratrol 2.5816162502 16183991
MESH:D000550 Amblyopia Valproic Acid 5.3717688650
MESH:D000740 Anemia Fluorouracil 8.9415504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.9411748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6417497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001169 Arthritis, Experimental resveratrol 3.5517115116
MESH:D050197 Atherosclerosis resveratrol 3.3216873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8517688650 18177632 17157402 16609825 15238991 20603192 18396377 18940202 19232924 18316065 19460635 18775368 18558336 17507914 18985861
MESH:D001714 Bipolar Disorder Valproic Acid 3.1120046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.1915746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.198888407
MESH:D002545 Brain Ischemia resveratrol 4.4017600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9920146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.9917474063
MESH:D001943 Breast Neoplasms Estradiol 2.9912948864 17289903 16675129 17018787 14630087 18497071 17261762 19861407
MESH:D001943 Breast Neoplasms Fluorouracil 2.9915136595 16110121 19217205 18608205 18357371 16595493 16557594
MESH:D001943 Breast Neoplasms resveratrol 2.9917651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9920435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8016051944
MESH:D002277 Carcinoma Fluorouracil 8.4017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4016835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.013084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.0116779866 18788625 18210153 20214788 19052882 20512989 19171122 18494052 18506893 20432363 17978847 17428255 21159647 10737359 16288022 18665156 3084413 16698587 17761372 17162532 18393292 17055752 19701751 16878318 20007298 10672840 19822196 16681979 19539802 11831363 17138121 16540662 19335982 18691550 3581430 18056438 17173139 19383236 20101231 19919837 16328049 16830150 20935162 19208518 16807293 18971187 19418558 19519916 19394651 20084675 16502159 18785209 20514400 16935385 20727157 16569478 19107877 18978308 20524982
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.0116924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 9.0117971768 16799960 17088986 17045692 16332177 18930000
MESH:D006528 Carcinoma, Hepatocellular resveratrol 9.0116227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.7116675471
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0518695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.7120419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.7118986760 17066447 16757204 16280240
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.7116227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases resveratrol 3.5315458977
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.4720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.4712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.4721159647 17174075 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.4718566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7320734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.5719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.5716835633
MESH:D002779 Cholestasis Cyclosporine 7.9619486331
MESH:D002779 Cholestasis pirinixic acid 7.9619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1315668235 8697196 12621046 16354765 15340226
MESH:D003092 Colitis resveratrol 4.2316474422
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9617725105 15001691 18772588 17169374 17016597 17172411 16510598 16340194 17018589 17287894
MESH:D003110 Colonic Neoplasms resveratrol 3.9616338953
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.7016391804 18509181 17016601 17454858 15289873 15148649 16282729 14970324 17695437 16331619 17094418 17401013 17594712 18383874 20501625 16303861 16524972 17255274 18802399 18288408 18949393 18448328
MESH:D015179 Colorectal Neoplasms resveratrol 2.7016550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.8016507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5020055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5016575769 8888407 17688650
MESH:D007644 Darier Disease Fluorouracil 4.9116733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.8416873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2817107852
MESH:D003928 Diabetic Nephropathies Estradiol 9.2619279558
MESH:D003928 Diabetic Nephropathies resveratrol 9.2616286809
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.1410774834 10915739 19370779 14725611 16485898 19085960 16081117 15968718 14986274 12705907 12594235 11421492 15619225 17906064 11834606 11739529 19923254 16781746 19164858 10663392 16393943 11743745 12958197 12153990 19420014 14550746 16227642 11461765 2444490 17522070 17562736 11529661 16109766 18713872 12392966 11287661 18071297 19739265 19416960 16177239 12540782
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.1419107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1420420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.1419641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004421 Dystonia Valproic Acid 4.141851702
MESH:D004487 Edema pirinixic acid 11.9112083418
MESH:D004487 Edema resveratrol 11.918985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.9111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.1217872969
MESH:D016889 Endometrial Neoplasms Estradiol 3.0311473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.9517923197
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.263659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.053922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.667562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.407750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.183659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.3416530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.3416337965 16481741 15173087 17638652 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Cyclosporine 19.4619224547
MESH:D005234 Fatty Liver Diethylnitrosamine 19.4621071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 19.4619236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 19.4614986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005315 Fetal Diseases Valproic Acid 5.0216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.2318558336 8888407
MESH:D005355 Fibrosis Cyclosporine 8.8312639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8320067830
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D005910 Glioma Fluorouracil 2.9016145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4418337622 15102660 15162350
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5810048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly pirinixic acid 8.6119772884 18467677 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6115340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D006561 Herpes Simplex resveratrol 4.3016876885
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006849 Hydrocephalus Valproic Acid 4.9817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1815340226 16354765 18606429 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006937 Hypercholesterolemia resveratrol 4.0917188708
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006949 Hyperlipidemias resveratrol 4.1116873680
MESH:D006973 Hypertension Cyclosporine 5.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7316612254
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.3817488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.7517600658
MESH:D007249 Inflammation Diethylnitrosamine 8.5718785209
MESH:D007249 Inflammation resveratrol 8.5716366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5712878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.6816624496
MESH:D007333 Insulin Resistance Estradiol 7.3716627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.3716306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 10.2412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.2418776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 10.2415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 12.8212371664
MESH:D007680 Kidney Neoplasms Estradiol 12.8215610895
MESH:D007680 Kidney Neoplasms Fluorouracil 12.8216985049
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell marker/mechanism 18006695
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1616294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.6316087638
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8719638242 18522880 18407596 18665156 20032147
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4212878042
MESH:D008107 Liver Diseases Acetaminophen 3.9711587558 12969438 19460945 16611625 19014921 12587719 19784758 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9717034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.3821137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.3819426721 18978307 20452335 20583210 20137499 20434301 12112319 19833225 15175105 19090486 19690152 20118626 18644402 20101389 21047994 19255062 19499222 19850985 16942905 18648771 18754104 19256749 21278145 19551842 19427195 21167192 19638242 21071580 19073162 15885732 19812893 10737359 12771043 20492335 19642983 20405173 19996281 2422723 20501860 19294768 18977376 9163691 2862719 19254457
MESH:D008113 Liver Neoplasms Fluorouracil 18.3817045692 18383874 16603448 15113037
MESH:D008113 Liver Neoplasms pirinixic acid 18.3816377806 15890375 20007298
MESH:D008113 Liver Neoplasms resveratrol 18.3820405173 19812893 19073162 19321006
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.3816984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 5.9318775883 16842330 18544905 16267830 3124819 17174075 19126423 18282651 18079962 18253720 19539802 18093689 19009564 21159647 19519916 17854601 18164116 18308698 17942915 19004024 9362446 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9312151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4017228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9018520028 6695378 17053015 20464547 20869020 20064080 18816296 18569708 20135361
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.906695378 21163286 20512841 20970405
MESH:D008175 Lung Neoplasms Fluorouracil 4.9015246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9019555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9115086387
MESH:D016393 Lymphoma, B-Cell resveratrol 4.3917088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.9414749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.3615688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.3217203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.3211606380 8985016
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008545 Melanoma resveratrol 2.3817992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008659 Metabolic Diseases resveratrol 4.4617112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D008881 Migraine Disorders Valproic Acid 3.2518803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.7416381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.7416757204 18986760
MESH:D009101 Multiple Myeloma resveratrol 3.5217935668 16267019 17049120 17164350 16490592 14749477
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.9917962980
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.118888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2017596541
MESH:D009203 Myocardial Infarction pirinixic acid 5.8419151258
MESH:D009203 Myocardial Infarction resveratrol 5.8417188708 17015251 16525036 16317513 16456233 17125593
MESH:D017202 Myocardial Ischemia resveratrol 9.2317015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.2312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.4616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.4616411023
MESH:D009205 Myocarditis resveratrol 4.8817322642
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.599029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 8.4411141357
MESH:D009369 Neoplasms Fluorouracil 8.4418239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 8.4417405874
MESH:D009374 Neoplasms, Experimental resveratrol 4.108985016
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3619348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.7811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7814600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.188888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 14.4618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 14.4620387270
MESH:D019636 Neurodegenerative Diseases resveratrol 14.4617652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.4917929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4916436463
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.3417513867
MESH:D010051 Ovarian Neoplasms CD 437 5.2417474084
MESH:D010051 Ovarian Neoplasms Estradiol 5.2419401270
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4116540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.4115113037 16500647 19003803 16929163
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.1912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.192563599
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 16.9916679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.9911896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 16.9920603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0717292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.0716740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0718626508 19082440
MESH:D011471 Prostatic Neoplasms resveratrol 2.0717718901 17636462 15767336 17804756 17675339 16731767
MESH:D019310 Pseudolymphoma Valproic Acid 4.6711422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0816160472 15538739 18286688 18722050
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.7216325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.7019058328
MESH:D015427 Reperfusion Injury resveratrol 6.7016314181 17520802 15827377 16317513 17058453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures Valproic Acid 2.7914763951 11738929 16876388 11044598 15475178 17978042 1511512 3137016
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.6519755658 10029692
MESH:D012878 Skin Neoplasms resveratrol 9.6515837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.6516192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6712833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.392093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3918456281
MESH:D013274 Stomach Neoplasms Fluorouracil 3.3916951190 16424979 18396642 17522103 15786421 17172411 17498489 18567086 19084572 19015929
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.5616321402
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.047505956
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 10.2416280240
MESH:D014062 Tongue Neoplasms resveratrol 10.2416227395
MESH:D014178 Translocation, Genetic Valproic Acid 5.3717262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.643119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.4717053015
MESH:D001749 Urinary Bladder Neoplasms CD 437 5.4716720286
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.758888407
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.8616803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 9.8617473185
MESH:D014594 Uterine Neoplasms resveratrol 4.2317044934
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.4117488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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