AutismKB 2.0

Annotation Detail for TRIOBP


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TRIOBP ( DFNB28,FLJ39315,KIAA1662,TARA,dJ37E16.4 )
Gene Full Name: TRIO and F-actin binding protein
Band: 22q13.1
Quick LinksEntrez ID:11078; OMIM: 609761; Uniprot ID:TARA_HUMAN; ENSEMBL ID: ENSG00000100101,ENSG00000100106; HGNC ID: 17009
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2207Deafness
No data
No data
Desease Name
Deafness, autosomal recessive 28
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TRIOBP mRNAaffects expression 17562736
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of TRIOBP mRNAincreases expression 17254854
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TRIOBP mRNAdecreases expression 20018196
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of TRIOBP mRNAdecreases expression 15336504
C056516 exemestane exemestane results in increased expression of TRIOBP mRNAincreases expression 17254854
D005472 Fluorouracil TRIOBP protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D010634 Phenobarbital Phenobarbital results in increased expression of TRIOBP mRNAincreases expression 19270015
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.836195326
MESH:D000230 Adenocarcinoma Fluorouracil 2.4817638652
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.3717620307
MESH:D000740 Anemia Fluorouracil 3.9817963324 16511603 15504547
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms exemestane 2.8916002280 17892469 17952589
MESH:D001943 Breast Neoplasms Fluorouracil 2.8915136595 16110121 19217205 18608205 16595493 18357371 16557594
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1116051944
MESH:D002277 Carcinoma Fluorouracil 3.7917121937
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.773084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.7717971768 18930000 17088986 17045692 16799960 16332177
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.7717173139 6705139 20007298 20935162 1701930
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1318695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5517066447 18986760 16757204 16280240
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9020889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2718772588 17018589 17725105 17287894 16510598 17169374 15001691 16340194 17172411 17016597
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0015289873 17094418 18509181 18448328 16303861 16282729 17454858 16391804 17401013 17594712 15148649 17016601 16331619 16524972 18383874 20501625 14970324 18802399 18949393 18288408 17255274 17695437
MESH:D007644 Darier Disease Fluorouracil 5.1916733453
OMIM:609823 DEAFNESS, AUTOSOMAL RECESSIVE 28 marker/mechanism
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6516393943 11461765 19164858 18071297 19370779 19416960 19420014 12540782 16081117 11739529 16227642 17522070 16485898 14725611 16109766 11421492 2444490 16781746 17562736 10663392 19923254 15968718 19085960 18713872 15619225 17906064 14986274 11743745 16177239 10915739 12392966 12958197 11834606 12705907 12594235 14550746 10774834 11529661 11287661 19739265 12153990
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004421 Dystonia Phenobarbital 4.311851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.473659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.3111558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.796401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.413659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7120426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.7116337965 16481741 15173087 16785472 17638652
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005910 Glioma Fluorouracil 2.9616145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5615162350 18337622 15102660
MESH:D006529 Hepatomegaly Phenobarbital 3.8416109766
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D007674 Kidney Diseases Acetaminophen 2.3412587719 15629191
MESH:D007680 Kidney Neoplasms Fluorouracil 3.5416985049
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0321047994
MESH:D008107 Liver Diseases Acetaminophen 4.1316611625 19460945 12969438 16610002 12587719 11587558 19014921 19784758
MESH:D008107 Liver Diseases Phenobarbital 4.1319363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms Fluorouracil 5.0016603448 15113037 18383874 17045692
MESH:D008113 Liver Neoplasms Phenobarbital 5.0019812893 8742319 19073162 21047994 19482888 15975961
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.866150874 1399818 2563599 17172636 18308698
MESH:D008175 Lung Neoplasms Fluorouracil 2.0115246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.1915086387
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8416757204 18986760
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009369 Neoplasms Fluorouracil 2.7218239605 18600527 16928823
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6116436463
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.6319003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.6316965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.872563599
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3719082440 18626508
MESH:D019310 Pseudolymphoma Phenobarbital 4.9412752131
MESH:D012004 Rectal Neoplasms Fluorouracil 4.2615538739 18286688 16160472 18722050
MESH:D012640 Seizures Phenobarbital 2.8711442880 16876388 4039156 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.808532709
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0016424979 18567086 17522103 17172411 18396642 19084572 15786421 17498489 19015929 16951190
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.261399818
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2516280240
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1416803524
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA142670699
    • No data
    Releated disease ID Related disease Name
    PA145069464Deafness,nonsyndromic
    PA145069467Hearing Loss, nonsyndromic
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved