AutismKB 2.0

Annotation Detail for CHD4


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Basic Information Top
Gene Symbol:CHD4 ( DKFZp686E06161,Mi-2b,Mi2-BETA )
Gene Full Name: chromodomain helicase DNA binding protein 4
Band: 12p13.31
Quick LinksEntrez ID:1108; OMIM: 603277; Uniprot ID:CHD4_HUMAN; ENSEMBL ID: ENSG00000111642; HGNC ID: 1919
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200070Signaling events mediated by HDAC Class I
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CHD4 mRNAaffects expression 21346803
D001151 Arsenic Arsenic results in decreased expression of CHD4 mRNAdecreases expression 19654921
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CHD4 mRNAaffects binding|increases activity|increases expression 19710929
D012643 Selenium Selenium results in increased expression of CHD4 mRNAincreases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of CHD4 mRNAaffects expression 17440010
C025643 vinclozolin vinclozolin results in decreased expression of CHD4 mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.7317306315
MESH:D001008 Anxiety Disorders vinclozolin 3.8919015723
MESH:D020261 Arsenic Poisoning Arsenic 2.9312569548 16835338 18414634 16251483
MESH:D050197 Atherosclerosis Arsenic 3.4212928151 19371607
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7517687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.2716705839
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.2717306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7618922899 15504454 17687452
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3818640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.6615738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.6018022660 16973168
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.986135515
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D003092 Colitis Selenium 4.2017936198
MESH:D003456 Cryptorchidism vinclozolin 4.7214966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.4418551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.1818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Selenium 4.1815131321
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D005234 Fatty Liver pirinixic acid 3.0919236843 20131406
MESH:D005534 Foot Diseases Arsenic 6.086392382
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.8216417039
MESH:D006333 Heart Failure pirinixic acid 7.5520558911
MESH:D006333 Heart Failure Selenium 7.5517162251
MESH:D006529 Hepatomegaly pirinixic acid 3.4116221962 19176532 18467677 19772884
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.2717440010
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.7617050553
MESH:D006973 Hypertension Arsenic 2.9616076760 11953799 9931084
MESH:D006987 Hypesthesia Arsenic 6.0816093927
MESH:D007248 Infertility, Male vinclozolin 3.2416467254
MESH:D007251 Influenza, Human Selenium 4.7216624496
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007642 Keratosis Arsenic 5.4512749816 16930632
MESH:D007676 Kidney Failure, Chronic Selenium 4.2116518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2416705839
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7417339181
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1916417039
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Arsenic 2.6011134558
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 8.047678174
MESH:D008113 Liver Neoplasms Arsenic 8.0416368122
MESH:D008113 Liver Neoplasms pirinixic acid 8.0415890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.722876784 6135515 2876786
MESH:D008175 Lung Neoplasms Arsenic 2.2119168569 17976673 17306315
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9515318939
MESH:D008654 Mesothelioma Selenium 2.8915107826
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D017202 Myocardial Ischemia Arsenic 4.2415371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.327678174 18551238
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D009436 Neural Tube Defects Arsenic 3.6416620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.7317056641
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7416049721
MESH:D010051 Ovarian Neoplasms Arsenic 2.8217306315
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.5616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.456392382 16905509 15371236
MESH:D010954 Plasmacytoma Selenium 5.4115087411
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.3618220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.4018220299
MESH:D011471 Prostatic Neoplasms Arsenic 3.5616140617
MESH:D011472 Prostatitis vinclozolin 5.4018629315
MESH:D011507 Proteinuria Arsenic 4.3521343184
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7418551238
MESH:D012871 Skin Diseases Arsenic 2.8118709164 16759981 19834688 16353154 15952646 17548696 17938729 17453740 6392382 16702368 17050553
MESH:D012878 Skin Neoplasms Arsenic 3.1319538983 17050553 15504454 16251483 17029826 17976673
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.5516049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.5511144890 17976673 19322015 17306315 18640142 19429237 15987713
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7810091137
MESH:D014652 Vascular Diseases Arsenic 5.2017056641
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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