AutismKB 2.0

Annotation Detail for ADAMTS13


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Basic Information Top
Gene Symbol:ADAMTS13 ( C9orf8,DKFZp434C2322,FLJ42993,MGC118899,MGC118900,TTP,VWFCP,vWF-CP )
Gene Full Name: ADAM metallopeptidase with thrombospondin type 1 motif, 13
Band: 9q34.2
Quick LinksEntrez ID:11093; OMIM: 604134; Uniprot ID:ATS13_HUMAN; ENSEMBL ID: ENSG00000160323; HGNC ID: 1366
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Hematologic diseases
H00225Thrombotic thrombocytopenic purpura
Desease IDDesease Name
1831Prostate cancer
1858Hemorrhagic disorder
1860Brain tumor
1902Kidney failure
2091Hypertension
2053Colon cancer
2087Bacterial infection
2111Systemic infection
2114Thrombocytopenia
2173Hematopoietic system disease
2233Cirrhosis
2237Neoplasm metastasis
2240Anemia
2257Hemolytic-Uremic syndrome
Desease Name
plasma levels of liver enzymes
METABOLIC
Desease Name
Plasma levels of liver enzymes
Desease Name
Thrombotic thrombocytopenic purpura, familial
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased activity of ADAMTS13 proteinincreases activity 16689760
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ADAMTS13 proteinincreases expression 16689760
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased activity of ADAMTS13 proteindecreases activity 17383642
D008767 Methylmercury Compounds Methylmercury Compounds results in increased expression of ADAMTS13 mRNAincreases expression 16966085
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma Diethylnitrosamine 3.086695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.6417620307 19052882 16434500 19061943 17162532 18056438
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1917474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.4316050911 15700767 16192424 16227642 3786805 15673190 10355542 15721981 16097048 18705752 16011737 16124888
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.1719394651 16288022 19335982 17173139 3581430 19539802 20432363 16779866 20084675 20007298 16698587 19171122 18056438 17761372 18971187 16569478 18691550 21159647 16681979 3084413 16540662 19052882 17428255 18210153 20935162 20214788 18665156 18393292 16830150 11831363 18785209 20524982 10737359 19822196 19418558 18506893 16807293 17978847 19519916 17138121 10672840 19701751 20512989 16935385 19208518 17055752 16502159 17162532 20514400 19383236 18978308 18494052 19919837 19107877 16328049 20101231 20727157 18788625 16878318
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.152727394 7505956 21159647 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 4.1019052882
MESH:D003704 Dementia Methylmercury Compounds 5.4816140633
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2720387270
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.2519085960 21278145 3732212 3786805 11566570 10915739 7120509 7179309 19336974 6884620 7440962 10092053 16177239 15027814 16227642 6623471 15968718 15998439 17522070 4309450 9327722 2869522
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.2519107877
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.9816302075
MESH:D005234 Fatty Liver Carbon Tetrachloride 9.4812631006 16239168 15959796 17595544 19224547 16045604 61145 12795759
MESH:D005234 Fatty Liver Diethylnitrosamine 9.4820387270 21071580
MESH:D005355 Fibrosis Carbon Tetrachloride 4.1018705752
MESH:D006505 Hepatitis Carbon Tetrachloride 4.1819900420 19110552
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.2716899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.7415338365
MESH:D007249 Inflammation Diethylnitrosamine 2.5718785209
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.3217174718 16943688 16239168 17157831 21278145 16221502 17334410 11903743 11408273
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 7.3218665156 20032147 18407596 18522880 19638242
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7515996030 16097048 12958196 17900296 15893842 15370692 15650968 18420326 18156304 14512876 14724832 17869086 17766677 16638106 20821823 17976157 12586293 16033810 11481614 17823541 18418968 18251166 12741479 18472094 18187930 18472332 12667390 12389079 17631135 17481882 17525996 18263696 12632512 16136751 16192424 17698563 13678700 15052691 18166357 15931870 18481824 18277467 12445421 14716833 17640975 15959796 15057751 14620537 18705752 14748882 16116963 12445418 15876570 17922224 18317297 16011737 17944888 18054572 17565644 12666154 12546737 17714472 15123356 18376398 18279442 14716496 18395914 18395095 17805973 12609069 17557913 15925388 15818738 16015684 15673190 18006644 15730626 12649538 16248980 18210741 15362042 18339082 16027843 17721639 12898905 18205269 17708605 12632514 15338365 17761835 18429990 18412020 10355542
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.3616964402 16246199 17285989 15830285 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 4.3617034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.8215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.1414706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 5.0319294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 5.0319690152 21167192 18644402 15175105 19294768 20101389 19638242 19850985 19427195 19254457 21278145 15885732 12112319 20434301 19073162 18648771 12771043 20583210 18754104 18978307 19499222 2422723 19812893 20118626 18977376 19090486 20452335 19833225 19426721 9163691 20137499 21071580 16942905 19256749 19642983 19255062 19996281 20501860 21047994 2862719 19551842 10737359 20492335 20405173
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.8015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.8018775883 18093689 18079962 19004024 18253720 17174075 18164116 19519916 19126423 3124819 18544905 9362446 21159647 2563599 18308698 18282651 16842330 17942915 19539802 17854601 19009564 16267830
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7720970405 6695378 21163286 20512841
MESH:D008569 Memory Disorders Methylmercury Compounds 5.4918436314
MESH:D009069 Movement Disorders Methylmercury Compounds 5.8518436314
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.703581430 9029167
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.7320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.9820387270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5416540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.972563599
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 5.7218436314
MESH:D011697 Purpura, Thrombotic Thrombocytopenic marker/mechanism 12656756
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.327505956
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24539
    • Releated gene ID Related gene Name
    PA24539ADAMTS13
    No data
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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