AutismKB 2.0

Annotation Detail for ADCY5


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Basic Information Top
Gene Symbol:ADCY5 ( AC5 )
Gene Full Name: adenylate cyclase 5
Band: 3q21.1
Quick LinksEntrez ID:111; OMIM: 600293; Uniprot ID:ADCY5_HUMAN; ENSEMBL ID: ENSG00000173175; HGNC ID: 236
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04270Vascular smooth muscle contraction
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa05414Dilated cardiomyopathy
hsa04540Gap junction
hsa04970Salivary secretion
hsa04972Pancreatic secretion
hsa00230Purine metabolism
hsa04971Gastric acid secretion
hsa04114Oocyte meiosis
hsa04062Chemokine signaling pathway
Pathway IDPathway Name
Signaling by GPCR
Diabetes pathways
Signalling by NGF
Transmembrane transport of small molecules
Opioid Signalling
Integration of energy metabolism
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00019Endothelin signaling pathway
P05731GABA-B receptor II signaling
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
two-hour glucose challenge
fasting glucose-related traits
METABOLIC
Desease Name
Fasting glucose-related traits
Two-hour glucose challenge
Birth weight
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C061282 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine ADCY5 protein results in increased susceptibility to 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosineincreases response to substance 12223546
C061282 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine ADCY5 protein results in increased susceptibility to [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine co-treated with Quinpirole]affects cotreatment|increases response to substance 12223546
D002118 Calcium Calcium results in decreased activity of ADCY5 proteindecreases activity 12065575
D002220 Carbamazepine Carbamazepine inhibits the reaction [Forskolin results in increased activity of ADCY5 protein]decreases reaction|increases activity 19922557
D002220 Carbamazepine Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY5 protein]affects binding|decreases reaction|increases activity 19922557
D002220 Carbamazepine Carbamazepine results in decreased activity of ADCY5 proteindecreases activity 19922557
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of ADCY5 mRNAaffects cotreatment|increases expression 18636392
D003024 Clozapine ADCY5 protein affects the susceptibility to Clozapineaffects response to substance 12223546
D003024 Clozapine SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Clozapine]affects response to substance|decreases reaction 12223546
C061532 dihydrexidine ADCY5 protein results in increased susceptibility to dihydrexidineincreases response to substance 12223546
C061532 dihydrexidine ADCY5 protein results in increased susceptibility to [dihydrexidine co-treated with Quinpirole]affects cotreatment|increases response to substance 12223546
D005557 Formaldehyde Formaldehyde results in decreased expression of ADCY5 mRNAdecreases expression 14756816
D005576 Forskolin ADCY5 protein results in increased susceptibility to [Forskolin co-treated with Quinpirole]affects cotreatment|increases response to substance 12223546
D005576 Forskolin Carbamazepine inhibits the reaction [Forskolin results in increased activity of ADCY5 protein]decreases reaction|increases activity 19922557
D005576 Forskolin Forskolin results in increased activity of ADCY5 proteinincreases activity 19922557
D006220 Haloperidol ADCY5 protein affects the susceptibility to Haloperidolaffects response to substance 12223546
D006220 Haloperidol SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Haloperidol]affects response to substance|decreases reaction 12223546
D008094 Lithium Lithium results in decreased activity of ADCY5 proteindecreases activity 19922557
D008094 Lithium Magnesium inhibits the reaction [Lithium results in decreased activity of ADCY5 protein]decreases activity|decreases reaction 19922557
D008274 Magnesium Magnesium results in increased activity of ADCY5 proteinincreases activity 12065575
D008274 Magnesium Magnesium inhibits the reaction [Lithium results in decreased activity of ADCY5 protein]decreases activity|decreases reaction 19922557
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of ADCY5 mRNAaffects cotreatment|increases expression 18636392
D010269 Paraquat Paraquat results in increased expression of ADCY5 mRNAincreases expression 17077588
D019257 Quinpirole ADCY5 protein results in increased susceptibility to [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine co-treated with Quinpirole]affects cotreatment|increases response to substance 12223546
D019257 Quinpirole ADCY5 protein results in increased susceptibility to [dihydrexidine co-treated with Quinpirole]affects cotreatment|increases response to substance 12223546
D019257 Quinpirole ADCY5 protein results in increased susceptibility to [Forskolin co-treated with Quinpirole]affects cotreatment|increases response to substance 12223546
D019257 Quinpirole ADCY5 protein results in increased susceptibility to [Quinpirole co-treated with VIP protein]affects cotreatment|increases response to substance 12223546
C534628 SCH 23390 SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Clozapine]affects response to substance|decreases reaction 12223546
C534628 SCH 23390 SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Haloperidol]affects response to substance|decreases reaction 12223546
C071262 SK&F 82958 Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY5 protein]affects binding|decreases reaction|increases activity 19922557
C071262 SK&F 82958 [SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY5 proteinaffects binding|increases activity 19922557
D013469 Sulpiride ADCY5 protein results in increased susceptibility to Sulpirideincreases response to substance 12223546
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ADCY5 mRNAdecreases expression 19933214
D015647 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine ADCY5 protein results in increased susceptibility to 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineincreases response to substance 12223546
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 8.508986270
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.5011752688 15322242 14514962
MESH:D055371 Acute Lung Injury Chlorine 4.2620601635
MESH:D000236 Adenoma Magnesium 4.5117823441
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3216835633
MESH:D000380 Agranulocytosis Clozapine 4.9914617031 16160616 12649775
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.7011874814
MESH:D000544 Alzheimer Disease Lithium 4.6619621015
MESH:D000544 Alzheimer Disease Ozone 4.6615513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D000855 Anorexia 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine 11.0712183048
MESH:D000855 Anorexia Quinpirole 11.0712183048
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5415570426
MESH:D001249 Asthma Ozone 2.6216373670 17854713
MESH:D001321 Autistic Disorder Haloperidol 2.9218080171 19368416
MESH:D001321 Autistic Disorder Magnesium 2.9216846101
MESH:D001714 Bipolar Disorder Carbamazepine 7.9020046352 17594078
MESH:D001714 Bipolar Disorder Lithium 7.9020338123 20046352 17594078 19153942
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D001943 Breast Neoplasms Formaldehyde 2.6515986119
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.6520435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6216777450 19059883 18417511 18315731 15516495 14754758 17626835
MESH:D002100 Cachexia Ozone 4.6816183385
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3318850075 18670907 16120746
MESH:D002375 Catalepsy Haloperidol 4.851977408 15215559
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1016835633
MESH:D016770 Ciliophora Infections Formaldehyde 5.5912113305
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.088697196 15668235 15340226 12621046 16354765
MESH:D003072 Cognition Disorders Clozapine 4.9017123785
MESH:D003111 Colonic Polyps Magnesium 5.9917823441
MESH:D015179 Colorectal Neoplasms Magnesium 3.4517823441
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0014669216 17141729
MESH:D019465 Craniofacial Abnormalities Carbamazepine 2.849014606
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8410048152 20055451 15322242
MESH:D007644 Darier Disease Lithium 5.8520338123
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.7820210726
MESH:D003704 Dementia Haloperidol 4.5211575062
MESH:D017449 Dermatitis, Allergic Contact Formaldehyde 4.6515059100 16958921 15932584 12081698 14996049
MESH:D002658 Developmental Disabilities Magnesium 4.8616846101
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.6819244398
MESH:D003924 Diabetes Mellitus, Type 2 marker/mechanism 20081858
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.4516402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4517107852
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.5015331141
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.3811748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.3716538175 20216337 16538176 15057820
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 4.1017465707
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.1020420201
MESH:D004362 Drug Toxicity Carbamazepine 8.2320216337
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.2311462148
MESH:D050171 Dyslipidemias Clozapine 4.1316402076
MESH:D004417 Dyspnea Chlorine 4.5720016425
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8518230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 4.6717654737
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9610568697 9294722
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.1916415921 16538176 20485159 18855540 19915237
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 5.1517275665
MESH:D004828 Epilepsies, Partial Carbamazepine 4.9217116037 16628512 15008574
MESH:D004827 Epilepsy Carbamazepine 3.9617178248 17465707 18234410 821787 7988514 19620853 20417680 19700373 9014606 19439326
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 5.297750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 5.0615276670 3659116
MESH:D004916 Erythromelalgia Carbamazepine 5.6619549232
MESH:D005076 Exanthema Carbamazepine 5.4120485159
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D005141 Eyelid Diseases Formaldehyde 6.3214996049
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8920067830
MESH:D005393 Fish Diseases Formaldehyde 5.5512113305
MESH:D005739 Gas Poisoning Chlorine 4.9520016425
MESH:D005911 Gliosis Paraquat 5.1111124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006330 Heart Defects, Congenital Lithium 6.9119638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9111294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8315340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9915340226 16959395 8697196 16354765 18606429
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.6710459572
MESH:D006948 Hyperkinesis Clozapine 12.0716046005
MESH:D006948 Hyperkinesis dihydrexidine 12.0714960337
MESH:D006965 Hyperplasia Carbamazepine 5.1518773962
MESH:D006973 Hypertension marker/mechanism 12717102
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8818670907 18850075
MESH:D007248 Infertility, Male Paraquat 3.214850670
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8212878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2716580747
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.9916316344
MESH:D008064 Lipidoses Clozapine 3.9117567588
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.6916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.0712151625
MESH:D008171 Lung Diseases Ozone 3.3319066396 8266340
MESH:D055370 Lung Injury Ozone 3.7820417186
MESH:D008175 Lung Neoplasms Ozone 2.368597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3611884234 19555203
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.5516628512
MESH:D008275 Magnesium Deficiency Magnesium 6.3817823441
MESH:D001523 Mental Disorders Clozapine 13.2216856516
MESH:D001523 Mental Disorders Haloperidol 13.2216856516
MESH:D001523 Mental Disorders Sulpiride 13.2216856516
MESH:D008607 Mental Retardation Carbamazepine 3.709014606
MESH:D024821 Metabolic Syndrome X Clozapine 4.3519142101
MESH:D008679 Metaplasia Ozone 5.0510496685
MESH:D008881 Migraine Disorders Magnesium 4.7218803445
MESH:D009203 Myocardial Infarction Lithium 3.9016288908
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D009224 Myotonia Congenita Carbamazepine 5.4120399394
MESH:D009410 Nerve Degeneration Paraquat 3.6616893418
MESH:D009421 Nervous System Malformations Carbamazepine 9.7116990009
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7114600291
MESH:D009669 Nose Neoplasms Formaldehyde 5.284038687
MESH:D009765 Obesity Clozapine 3.0018515891 19142110
MESH:D010018 Osteomalacia Carbamazepine 5.4117016548
MESH:D010024 Osteoporosis Calcium 3.7417882678
MESH:D010146 Pain Carbamazepine 3.9815215642
MESH:D010267 Parapsoriasis Carbamazepine 5.6416538176
MESH:D010300 Parkinson Disease Paraquat 2.7916140633 16510128 15824117 15451049 11445065 12911755 11181820 11124998
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.3716190885
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.8617679678 17145499
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010538 Peritonitis Ozone 4.0716369182
MESH:D011014 Pneumonia Ozone 10.8618007984 18929643 18381685
MESH:D011014 Pneumonia Paraquat 10.8612504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011248 Pregnancy Complications Carbamazepine 5.099014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 9.659014606
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.6511896295 11399792 11118676 11222880
MESH:D019310 Pseudolymphoma Carbamazepine 5.5412752131 9591791
MESH:D011595 Psychomotor Agitation Haloperidol 4.8911575062
MESH:D011618 Psychotic Disorders Clozapine 9.0015331141
MESH:D011618 Psychotic Disorders Haloperidol 9.0011575062
MESH:D011658 Pulmonary Fibrosis Paraquat 2.8917997886 16324872
MESH:D012120 Respiration Disorders Chlorine 5.1618579056
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.8411700416
MESH:D012135 Respiratory Sounds Paraquat 3.9911874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012162 Retinal Degeneration Paraquat 3.8216458197
MESH:D012559 Schizophrenia Clozapine 4.0620168265 19369910 17667964 20521320 20452607 11763009 18855531 18806925 20107430 11151749 17726453 17123785 20580759 20521326 16141801
MESH:D012559 Schizophrenia Haloperidol 4.061830565 20107430 19369910 18513383
MESH:D012595 Scleroderma, Systemic Formaldehyde 5.8014979077
MESH:D012640 Seizures Carbamazepine 6.719844417 16180713 9046859 16938433 16876388 19414003 15946322
MESH:D012640 Seizures Lithium 6.7119660546
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0116192470
MESH:D012893 Sleep Disorders Carbamazepine 5.0619414003
MESH:D013226 Status Epilepticus Lithium 5.7319430551 19951488 19570321
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.1516538176 19915237 16415921 18855540 20485159 19694795 15057820
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.6420210726
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
MESH:D015430 Weight Gain Clozapine 4.4120521320 16141801 20564506 17502770 16402076 20107430
MESH:D015431 Weight Loss Clozapine 5.0217933447
Pathway ID Pathway Name
KEGG:04976 Bile secretion
KEGG:04062 Chemokine signaling pathway
REACT:15380 Diabetes pathways
KEGG:05414 Dilated cardiomyopathy
KEGG:04540 Gap junction
KEGG:04971 Gastric acid secretion
KEGG:04724 Glutamatergic synapse
KEGG:04912 GnRH signaling pathway
REACT:1505 Integration of energy metabolism
KEGG:04916 Melanogenesis
KEGG:04114 Oocyte meiosis
REACT:15295 Opioid Signalling
KEGG:04972 Pancreatic secretion
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:00230 Purine metabolism
KEGG:04970 Salivary secretion
REACT:30320 Signaling by GPCR
REACT:14797 Signaling by GPCR
REACT:11061 Signalling by NGF
REACT:13685 Synaptic Transmission
REACT:15518 Transmembrane transport of small molecules
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24563
    • No data
    Releated disease ID Related disease Name
    PA443890Diabetes Mellitus, Type 2
    Releated drug ID Related drug Name
    PA165290926fluticasone/salmeterol
    PA451300salmeterol
    PA164749238exenatide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02587 - Forskolin
    DB06843 - 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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