Annotation Detail for KRR1
Basic Information
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| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D015123 |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KRR1 mRNA | decreases expression | 20018196
|
| D008727 |
Methotrexate |
KRR1 protein affects the susceptibility to Methotrexate | affects response to substance | 16217747
|
| D008942 |
Mitoxantrone |
KRR1 protein affects the susceptibility to Mitoxantrone | affects response to substance | 16217747
|
| C029938 |
nickel sulfate |
nickel sulfate results in decreased expression of KRR1 mRNA | decreases expression | 16780908
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000014 |
Abnormalities, Drug-Induced |
|
Methotrexate |
4.87 | 12039119 |
| MESH:D055371 |
Acute Lung Injury |
|
nickel sulfate |
4.77 | 11954676 16100012 19131640 12718980 |
| MESH:D001172 |
Arthritis, Rheumatoid |
|
Methotrexate |
3.17 | 17286800 |
| MESH:D001943 |
Breast Neoplasms |
|
Methotrexate |
3.07 | 16978400 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
2.98 | 20889678 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Methotrexate |
2.67 | 9562676 12039119 |
| MESH:D003550 |
Cystic Fibrosis |
|
Methotrexate |
4.63 | 19747007 |
| MESH:D017449 |
Dermatitis, Allergic Contact |
|
nickel sulfate |
4.22 | 16823706 11298694 16780908 |
| MESH:D003882 |
Dermatomyositis |
|
Methotrexate |
5.63 | 20191521 |
| MESH:D004938 |
Esophageal Neoplasms |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
2.15 | 20426865 |
| MESH:D006086 |
Graft vs Host Disease |
|
Methotrexate |
5.71 | 16518429 |
| MESH:D006331 |
Heart Diseases |
|
Mitoxantrone |
4.41 | 16019553 |
| MESH:D007805 |
Language Development Disorders |
|
Methotrexate |
5.57 | 9562676 |
| MESH:D015451 |
Leukemia, Lymphocytic, Chronic, B-Cell |
|
Mitoxantrone |
3.92 | 18172266 |
| MESH:D008103 |
Liver Cirrhosis |
|
Methotrexate |
3.89 | 14986274 |
| MESH:D017563 |
Lung Diseases, Interstitial |
|
Methotrexate |
5.74 | 18516814 |
| MESH:D008223 |
Lymphoma |
|
Methotrexate |
4.22 | 17352296 |
| MESH:D052016 |
Mucositis |
|
Methotrexate |
5.91 | 17488658 |
| MESH:D009369 |
Neoplasms |
|
Mitoxantrone |
3.58 | 16640825 |
| MESH:D011565 |
Psoriasis |
|
Methotrexate |
3.54 | 17410198 |
| MESH:D051437 |
Renal Insufficiency |
|
Methotrexate |
5.27 | 17352296 |
| MESH:D013576 |
Syndactyly |
|
Methotrexate |
5.54 | 9562676 |
Related Pathway Information