AutismKB 2.0

Annotation Detail for KATNA1


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Basic Information Top
Gene Symbol:KATNA1 ( - )
Gene Full Name: katanin p60 (ATPase-containing) subunit A 1
Band: 6q25.1
Quick LinksEntrez ID:11104; OMIM: 606696; Uniprot ID:KTNA1_HUMAN; ENSEMBL ID: ENSG00000186625; HGNC ID: 6216
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200114Lissencephaly gene (LIS1) in neuronal migration and development
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of KATNA1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of KATNA1 mRNAincreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of KATNA1 mRNAaffects expression 21346803
C006780 bisphenol A bisphenol A results in decreased expression of KATNA1 mRNAdecreases expression 20678512
D008713 Methimazole Methimazole results in decreased expression of KATNA1 mRNAdecreases expression 17403546
C494474 perchlorate perchlorate results in decreased expression of KATNA1 mRNAdecreases expression 17403546
D010634 Phenobarbital Phenobarbital results in increased expression of KATNA1 mRNAincreases expression 19363144
D011441 Propylthiouracil Propylthiouracil results in decreased expression of KATNA1 mRNAdecreases expression 17403546
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.836195326
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.3717620307
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 4.5519483382
MESH:D001862 Bone Resorption bisphenol A 4.1411985600
MESH:D001943 Breast Neoplasms bisphenol A 2.4417123778
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7816705839
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.7817173139 20935162 20007298 6705139 1701930
MESH:D002278 Carcinoma in Situ bisphenol A 5.3817123778
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.956135515
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.1218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.1218551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.0821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.0818551238 21346803
MESH:D004421 Dystonia Phenobarbital 4.311851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.473659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.313922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.796401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.413659116
MESH:D006042 Goiter perchlorate 5.6118801409
MESH:D006529 Hepatomegaly Phenobarbital 3.8416109766
MESH:D006980 Hyperthyroidism Methimazole 5.9514678291
MESH:D007037 Hypothyroidism Methimazole 13.1818031379
MESH:D007037 Hypothyroidism Propylthiouracil 13.1818031379 8137927
MESH:D007333 Insulin Resistance bisphenol A 3.4616393666
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.1516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.1516705839
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0321047994
MESH:D008107 Liver Diseases Phenobarbital 2.2219363144
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.887678174
MESH:D008113 Liver Neoplasms Phenobarbital 4.8819482888 19812893 8742319 21047994 19073162 15975961
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.492876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.491399818 2563599 17172636 6150874 18308698
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.7018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.7018551238 7678174
MESH:D009421 Nervous System Malformations bisphenol A 4.3011399458 16427766
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.7816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.7816049721
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D010049 Ovarian Diseases bisphenol A 5.3811985600
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5716965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.872563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.3510548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4920887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3616740699
MESH:D019310 Pseudolymphoma Phenobarbital 4.9412752131
MESH:D011629 Puberty, Precocious bisphenol A 5.1810548101
MESH:D012640 Seizures 2,4-dinitrotoluene 10.8918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.8918551238
MESH:D012640 Seizures Phenobarbital 10.893137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
MESH:D019966 Substance-Related Disorders bisphenol A 4.3816684133 16045194
MESH:D013964 Thyroid Neoplasms Phenobarbital 8.151399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 8.1515710170
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3216049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.3510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.3510091137
MESH:D014591 Uterine Diseases bisphenol A 5.4514652134
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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