AutismKB 2.0

Annotation Detail for PRDM4


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Basic Information Top
Gene Symbol:PRDM4 ( MGC45046,PFM1 )
Gene Full Name: PR domain containing 4
Band: 12q23.3
Quick LinksEntrez ID:11108; OMIM: 605780; Uniprot ID:PRDM4_HUMAN; ENSEMBL ID: ENSG00000110851; HGNC ID: 9348
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04722Neurotrophin signaling pathway
Pathway IDPathway Name
Signalling by NGF
Pathway IDPathway Name
200103p75(NTR)-mediated signaling
No data
Pathway IDPathway Name
500612p75NTR negatively regulates cell cycle via SC1
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PRDM4 mRNAaffects expression 17562736
D016572 Cyclosporine Cyclosporine results in increased expression of PRDM4 mRNAincreases expression 20106945
D014284 Triiodothyronine Triiodothyronine results in increased expression of PRDM4 mRNAincreases expression 19228888
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002386 Cataract Acetaminophen 2.8110977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.8212371664
MESH:D002779 Cholestasis Cyclosporine 3.2419486331
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6811461765 11739529 12958197 14550746 18071297 11529661 19420014 12540782 19085960 12594235 11834606 11287661 14986274 15619225 11421492 19164858 14725611 16485898 16109766 12153990 16081117 19370779 15968718 19739265 16177239 10663392 12705907 17562736 16781746 2444490 16227642 16393943 10774834 19923254 17522070 18713872 12392966 17906064 19416960 11743745 10915739
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D005234 Fatty Liver Cyclosporine 3.3419224547
MESH:D005355 Fibrosis Cyclosporine 3.7912639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.968708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.1615720958
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D006973 Hypertension Cyclosporine 2.2310903974
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.3115604871
MESH:D007674 Kidney Diseases Acetaminophen 6.5515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.558314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 3.1212371664
MESH:D008107 Liver Diseases Acetaminophen 1.7112587719 19784758 11587558 19460945 16611625 12969438 16610002 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6816871587 17185352
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.6516801185
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.7018481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D011230 Precancerous Conditions Cyclosporine 3.6412371664
MESH:D011565 Psoriasis Cyclosporine 2.3416882103
MESH:D014581 Urticaria Acetaminophen 3.5010982225
MESH:D014605 Uveitis Cyclosporine 4.851336536
MESH:D014985 Xerophthalmia Cyclosporine 5.3117120751
Pathway ID Pathway Name
KEGG:04722 Neurotrophin signaling pathway
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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