AutismKB 2.0

Annotation Detail for HIBADH


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Basic Information Top
Gene Symbol:HIBADH ( MGC40361,NS5ATP1 )
Gene Full Name: 3-hydroxyisobutyrate dehydrogenase
Band: 7p15.2
Quick LinksEntrez ID:11112; OMIM: 608475; Uniprot ID:3HIDH_HUMAN; ENSEMBL ID: ENSG00000106049; HGNC ID: 4907
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
VALDEG-PWYvaline degradation I
Pathway IDPathway Name
hsa00280Valine, leucine and isoleucine degradation
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of amino acids and derivatives
No data
No data
Pathway IDPathway Name
500780Branched-chain amino acid catabolism
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of HIBADH mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of HIBADH mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of HIBADH mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of HIBADH mRNAdecreases expression 17522070
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HIBADH mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of HIBADH mRNAdecreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of HIBADH mRNAdecreases expression 17522070
D002725 Chloroform Chloroform results in decreased expression of HIBADH mRNAdecreases expression 17522070
D016572 Cyclosporine Cyclosporine results in decreased expression of HIBADH mRNAdecreases expression 20106945
D003907 Dexamethasone Dexamethasone results in increased expression of HIBADH mRNAincreases expression 17522070
D004918 Erythromycin Estolate Erythromycin Estolate results in decreased expression of HIBADH mRNAdecreases expression 17522070
D004958 Estradiol Estradiol results in decreased expression of HIBADH mRNAdecreases expression 17522070
D000431 Ethanol Ethanol results in decreased expression of HIBADH mRNAdecreases expression 17920746
D005419 Flavonoids Flavonoids results in decreased expression of HIBADH mRNAdecreases expression 18035473
D015741 Metribolone Metribolone results in decreased expression of HIBADH proteindecreases expression 17152098
C044361 M-VAC protocol HIBADH protein results in increased susceptibility to M-VAC protocolincreases response to substance 15814643
D009255 Nafenopin Nafenopin results in increased expression of HIBADH proteinincreases expression 10903494
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in decreased expression of HIBADH mRNAdecreases expression 17522070
D011802 Quinidine Quinidine results in increased expression of HIBADH mRNAincreases expression 17522070
D013752 Tetracycline Tetracycline results in decreased expression of HIBADH mRNAdecreases expression 17522070
D013806 Theophylline Theophylline results in decreased expression of HIBADH mRNAdecreases expression 17522070
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 3.8317676605 18926900
MESH:D000138 Acidosis Ammonium Chloride 10.1818287403
MESH:D000138 Acidosis Ethanol 10.1811192467
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2120127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.2111473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.606695378
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.2415451039 15451040
MESH:D000799 Angioedema Acetaminophen 3.7610982225
MESH:D000853 Anophthalmos Ethanol 4.7315513904
MESH:D001008 Anxiety Disorders Ethanol 3.9311141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D001145 Arrhythmias, Cardiac Quinidine 5.0718724381 18057881
MESH:D001169 Arthritis, Experimental Dexamethasone 3.4817659584
MESH:D001249 Asthma Theophylline 3.839701106 12113382
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0717474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 2.0717261762 16675129 18497071 12948864 17018787 17289903 14630087 19861407
MESH:D002056 Burns Ethanol 4.5616374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6916097048 15673190 18705752 16227642 16192424 15721981 16124888 15700767 10355542 16011737 16050911 3786805
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.2116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.2116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.213084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.2118788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.2116924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 11.2118788625 15763234 15289165
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0320419170
MESH:D006332 Cardiomegaly Ethanol 3.3919332462
MESH:D002386 Cataract Acetaminophen 2.5310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.796135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.7912371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.7918566989
MESH:D002637 Chest Pain Theophylline 5.7915238202
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 6.1212912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 8.097624871 18164287 18590720 19486331 16629650 15500046 12927374 15913567
MESH:D002779 Cholestasis Cyclosporine 8.0919486331
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.7719407337 10220858
MESH:D002971 Cleft Lip Ethanol 3.5415513904
MESH:D002972 Cleft Palate Ethanol 3.1415513904
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4815824018
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.9817728286
MESH:D019465 Craniofacial Abnormalities Ethanol 2.9811873399 19302082 11198716 15451039 15513904 15451040 10194807
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.6018551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.6018551238
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.3212438553
MESH:D003928 Diabetic Nephropathies Estradiol 3.3319279558
MESH:D003967 Diarrhea Dexamethasone 3.617237001
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 25.4917522070 7624871 18289764 20133375
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 25.4918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 25.4918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 25.4918713872 16227642 12392966 17906064 19420014 19085960 19370779 12705907 15619225 15968718 11461765 19416960 18071297 16177239 17562736 16081117 12594235 14986274 16485898 14725611 19164858 10915739 11743745 11287661 10774834 16781746 11529661 19739265 16393943 16109766 11739529 12958197 10663392 11834606 12153990 11421492 14550746 17522070 12540782 19923254 2444490
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 25.493732212 2869522 7120509 6884620 3786805 21278145 15998439 19085960 7179309 10915739 10092053 15968718 15027814 4309450 11566570 17522070 19336974 7440962 6623471 16227642 16177239 9327722
MESH:D056486 Drug-Induced Liver Injury Chloroform 25.4917522070 3732212 6623471 6884620 7440962 3104120 2862719 7120509
MESH:D056486 Drug-Induced Liver Injury Erythromycin Estolate 25.4917522070 14998559
MESH:D056486 Drug-Induced Liver Injury Ethanol 25.4911566570
MESH:D056486 Drug-Induced Liver Injury Tetracycline 25.4917522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0219426721
MESH:D004485 Eczema Dexamethasone 4.3712438553
MESH:D004487 Edema Dexamethasone 3.3219703484
MESH:D016889 Endometrial Neoplasms Estradiol 2.9211473722 18566989 19148513
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5216530937
MESH:D004938 Esophageal Neoplasms Ethanol 4.5216704527
MESH:D005234 Fatty Liver Carbon Tetrachloride 18.1719224547 12631006 16239168 12795759 17595544 61145 16045604 15959796
MESH:D005234 Fatty Liver Cyclosporine 18.1719224547
MESH:D005234 Fatty Liver Ethanol 18.1716409862 19236843 18620774
MESH:D005234 Fatty Liver Tetracycline 18.1719224547 16917069
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.5817920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.2116946407 15513904 10194807 15451040
MESH:D005355 Fibrosis Carbon Tetrachloride 8.3818705752
MESH:D005355 Fibrosis Cyclosporine 8.3812639820 12168785
MESH:D005756 Gastritis Acetaminophen 10.8616983495
MESH:D005756 Gastritis Ethanol 10.8615046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6120471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 9.3718590720
MESH:D006505 Hepatitis Carbon Tetrachloride 9.3719110552 19900420
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.047520565
MESH:D006558 Herpes Genitalis Estradiol 4.9515709030
MESH:D019584 Hot Flashes Estradiol 3.6717088409
MESH:D006930 Hyperalgesia Acetaminophen 7.5716870215
MESH:D006930 Hyperalgesia Ethanol 7.5718783367
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4516899240
MESH:D006973 Hypertension Cyclosporine 5.2110903974
MESH:D006973 Hypertension Dexamethasone 5.2117042910
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0015338365
MESH:D007248 Infertility, Male Theophylline 4.3616988215
MESH:D007249 Inflammation Dexamethasone 5.2211099482 8960868
MESH:D007249 Inflammation Flavonoids 5.2217296493
MESH:D007333 Insulin Resistance Estradiol 2.9116393666 16627594
MESH:D007569 Jaw Abnormalities Ethanol 4.3215513904
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D007674 Kidney Diseases Acetaminophen 9.6812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.6818776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 9.6815618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 17.1316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 17.1316705839
MESH:D007680 Kidney Neoplasms Cyclosporine 17.1312371664
MESH:D007680 Kidney Neoplasms Estradiol 17.1315610895
MESH:D007859 Learning Disorders Ethanol 4.1215451040
MESH:D017880 Limb Deformities, Congenital Ethanol 3.7517676605
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.6516943688 17174718 11408273 16221502 11903743 21278145 17157831 16239168 17334410
MESH:D008103 Liver Cirrhosis Ethanol 6.6515289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.0118295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.9312445418 15123356 18418968 11481614 16638106 12741479 14716496 13678700 17525996 18420326 12898905 18279442 17698563 18156304 17922224 15996030 18054572 14724832 17708605 12586293 18472094 12445421 17823541 15876570 17481882 17721639 17805973 16097048 17869086 12958196 15338365 10355542 15931870 15650968 17761835 15057751 16136751 18705752 18395914 15893842 14620537 16027843 14748882 17944888 16015684 14716833 18006644 18205269 14512876 12632512 16248980 16192424 12667390 17631135 12389079 18429990 18251166 18481824 15818738 15362042 12632514 18166357 12666154 18339082 15730626 18187930 18210741 17900296 18376398 20821823 12649538 16033810 18277467 17640975 15925388 12609069 17714472 18395095 18412020 17766677 18472332 16116963 15673190 17565644 12546737 16011737 17557913 18263696 15370692 17976157 18317297 15052691 15959796
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 4.9316718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 4.9318166357
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 6.4817184895
MESH:D008107 Liver Diseases Acetaminophen 6.4811587558 19784758 12587719 19014921 16610002 12969438 16611625 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.4815830285 16964402 15720792 16246199 17285989
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.5617207112 17347304
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.1417185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.1414706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.237678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.2320195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.2319294768
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.742876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.7412014681 15583823
MESH:D008133 Long QT Syndrome Quinidine 4.8615350150 11989578
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5318569708 17053015 20464547 6695378 18816296 20135361 18520028 20869020 20064080
MESH:D008175 Lung Neoplasms Dexamethasone 2.5311195469 15824018
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5017203775 11807958 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.4019453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4819513568
MESH:D008569 Memory Disorders Ethanol 4.1018411066 15451040
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1216381670
MESH:D009101 Multiple Myeloma Dexamethasone 3.4416118317 15867202 15744524
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.499809623
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2116810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.0618551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.067678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1311141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6517289903
MESH:D009395 Nephritis, Interstitial Tetracycline 4.709884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2119348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 3.5611399458 16427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8018514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.6212819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.6216049721
MESH:D010051 Ovarian Neoplasms Estradiol 2.1919401270
MESH:D010146 Pain Acetaminophen 2.3216870215
MESH:D010190 Pancreatic Neoplasms Ethanol 2.9412384795
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 5.7720133375
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.3511026799
MESH:D011230 Precancerous Conditions Cyclosporine 3.1412371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.4921297632
MESH:D017096 Prion Diseases Tetracycline 5.3310903871
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8020887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1417292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.1416740699
MESH:D011565 Psoriasis Cyclosporine 2.2016882103
MESH:D029424 Pulmonary Disease, Chronic Obstructive Theophylline 5.0618983928
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.9318379247 11700416
MESH:D012640 Seizures 2,4-dinitrotoluene 9.5218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.5218551238
MESH:D012640 Seizures Ethanol 9.529754883
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3319755658 10029692
MESH:D013272 Stomach Diseases Dexamethasone 4.2415472012
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.5120155912 2093021
MESH:D013274 Stomach Neoplasms Ethanol 2.5118456281
MESH:D013276 Stomach Ulcer Dexamethasone 7.2815138204
MESH:D013276 Stomach Ulcer Ethanol 7.289211565 11906479 9562338 16755016 17189318 17918041
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.179754883
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.6720133375
MESH:D013978 Tibial Fractures Estradiol 4.6019048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.0616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.0616049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.0617053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 20.5810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 20.5810091137
MESH:D014571 Urologic Neoplasms M-VAC protocol 20.5817933135
MESH:D014581 Urticaria Acetaminophen 2.8910982225
MESH:D014605 Uveitis Cyclosporine 11.501336536
MESH:D014605 Uveitis Dexamethasone 11.501336536
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
KEGG:00280 Valine, leucine and isoleucine degradation
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29280
    • No data
    No data
    Releated drug ID Related drug Name
    PA451843l-valine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00157 - NADH Dietary supplement;Micronutrient
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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