AutismKB 2.0

Annotation Detail for CIT


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Basic Information Top
Gene Symbol:CIT ( CRIK,KIAA0949,STK21 )
Gene Full Name: citron (rho-interacting, serine/threonine kinase 21)
Band: 12q24.23
Quick LinksEntrez ID:11113; OMIM: 605629; Uniprot ID:CTRO_HUMAN; ENSEMBL ID: ENSG00000122966; HGNC ID: 1985
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200007RhoA signaling pathway
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Related Diseases/Disorders Top
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Desease IDDesease Name
2045Bipolar disorder
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of CIT mRNAincreases expression 18648102
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CIT proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CIT mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of CIT mRNAdecreases expression 18929588
D001205 Ascorbic Acid [Quercetin co-treated with Ascorbic Acid] results in increased expression of CIT mRNAaffects cotreatment|increases expression 17639512
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CIT mRNAdecreases expression 20106945
20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CIT mRNAincreases expression 20504355
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CIT mRNAdecreases expression 20382639
D019833 Genistein Genistein affects the expression of CIT mRNAaffects expression 18847459
D011794 Quercetin [Quercetin co-treated with Ascorbic Acid] results in increased expression of CIT mRNAaffects cotreatment|increases expression 17639512
C017947 sodium arsenite sodium arsenite results in increased expression of CIT mRNAincreases expression 16014739
C025643 vinclozolin vinclozolin affects the expression of CIT mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5320127859 20464547
MESH:D000230 Adenocarcinoma Genistein 4.5311473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.853712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.856695378
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1217306315 16712894
MESH:D000743 Anemia, Hemolytic Quercetin 4.3817084956
MESH:D001008 Anxiety Disorders vinclozolin 3.7519015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001260 Ataxia Telangiectasia Quercetin 5.1715336622
MESH:D001327 Autoimmune Diseases Quercetin 4.5819761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.241440618 11289319
MESH:D001943 Breast Neoplasms Ascorbic Acid 2.0416443354
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0417474063 20146248
MESH:D001943 Breast Neoplasms Genistein 2.0417200150 16873071 16541309
MESH:D001943 Breast Neoplasms Quercetin 2.0418628248
MESH:D002105 Cadmium Poisoning Quercetin 5.7616962696
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.117296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 9.1112907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Genistein 9.1116924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 9.1119519916 12508355
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 9.1115276417 17306315 16507464
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.1317234771
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.737296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7220419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.7218572023
MESH:D006332 Cardiomegaly Quercetin 3.3919794523
MESH:D002318 Cardiovascular Diseases Genistein 3.4016332659
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.757505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.7520889678
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.7519524636 20056578
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.259022650 19486331
MESH:D003110 Colonic Neoplasms arsenite 6.0915037631
MESH:D003110 Colonic Neoplasms Genistein 6.0917182828
MESH:D003110 Colonic Neoplasms Quercetin 6.0915741050 17191121 17148506 16640504 19056647 11134977 19440933
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D003139 Common Cold Ascorbic Acid 5.6917323712
MESH:D003456 Cryptorchidism vinclozolin 4.5014966744
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.978156756 18759878 12868966 2524372 11906362 11298694 14531868 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.642952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8519496084
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 4.9616506275
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.9616647724
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 1.996679447 9022650 18692083 7440962 6482804 9328219 11289319 8291058 18289764 18648102 9653073 1440618 16192314
MESH:C538011 Eales disease Ascorbic Acid 5.699068938
MESH:D004714 Endometrial Hyperplasia Genistein 4.7816402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4511473722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.373581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.3716530937
MESH:D005234 Fatty Liver arsenite 3.9218296743
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005355 Fibrosis arsenite 9.7618296743
MESH:D005355 Fibrosis Quercetin 9.7619474275
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5216417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8716452187
MESH:D005909 Glioblastoma Genistein 7.6416598420
MESH:D005909 Glioblastoma Quercetin 7.6419804834
MESH:D005910 Glioma Quercetin 3.1017643826
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 7.2016080930
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.2020471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.5116490937 16863852
MESH:D006689 Hodgkin Disease sodium arsenite 3.2712676792
MESH:D006943 Hyperglycemia Quercetin 4.1611834736 18262572
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D006973 Hypertension Quercetin 2.9018356687
MESH:D007248 Infertility, Male sodium arsenite 7.1515346721 12646999
MESH:D007248 Infertility, Male vinclozolin 7.1516467254
MESH:D007251 Influenza, Human Quercetin 4.7216624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.249022650 8074119
MESH:D007627 Keloid Quercetin 5.1317086741
MESH:D007674 Kidney Diseases Quercetin 6.5516962696
MESH:D007674 Kidney Diseases sodium arsenite 6.5520008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.086582329
MESH:D007938 Leukemia Genistein 6.7717468513 18980019
MESH:D007938 Leukemia Quercetin 6.7717468513
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9316417039
MESH:D008103 Liver Cirrhosis arsenite 3.4918296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.289327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.7917823541
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.7912741479
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.1418177683 9163691 2125692 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1420195826 21137059
MESH:D008113 Liver Neoplasms Quercetin 11.1418980244
MESH:D008113 Liver Neoplasms sodium arsenite 11.1415276417 16712894
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.91598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.918603461
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 14.9118544905
MESH:D008114 Liver Neoplasms, Experimental Quercetin 14.9119519916
MESH:D008171 Lung Diseases Ascorbic Acid 8.0316863852
MESH:D008171 Lung Diseases sodium arsenite 8.0319095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.7714755239
MESH:D008175 Lung Neoplasms arsenite 8.7716809336
MESH:D008175 Lung Neoplasms Ascorbic Acid 8.7716401635
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.7720464547 18816296 20064080 18569708 20135361 20869020 17053015 18520028 6695378
MESH:D008175 Lung Neoplasms Quercetin 8.7716280456
MESH:D008175 Lung Neoplasms sodium arsenite 8.7717306315 15276417 19931552 17077188 16712894
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0214578162 12929590
MESH:D008545 Melanoma sodium arsenite 2.0519082730 16487513
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009203 Myocardial Infarction Genistein 6.1617141266
MESH:D009203 Myocardial Infarction Quercetin 6.1619595682
MESH:D015428 Myocardial Reperfusion Injury Genistein 9.0617141266
MESH:D015428 Myocardial Reperfusion Injury Quercetin 9.0619207477
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.523581430
MESH:D009369 Neoplasms Benzo(a)pyrene 8.7011141357
MESH:D009369 Neoplasms Quercetin 8.7015185748
MESH:D009369 Neoplasms sodium arsenite 8.7011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8420056578
MESH:D009389 Neovascularization, Pathologic arsenite 4.6115738583
MESH:D009421 Nervous System Malformations Genistein 4.1916427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.556679447
MESH:D009436 Neural Tube Defects sodium arsenite 7.5512854658
MESH:D020078 Neurogenic Inflammation Quercetin 4.5117929310
MESH:D009765 Obesity Ascorbic Acid 3.1717217161
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.556482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010024 Osteoporosis Genistein 3.3319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 10.6416169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 10.6419495926
MESH:D010051 Ovarian Neoplasms Genistein 8.2119005980
MESH:D010051 Ovarian Neoplasms Quercetin 8.2119005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 8.2115276417 17306315
MESH:D010190 Pancreatic Neoplasms Quercetin 2.8916965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D011230 Precancerous Conditions Quercetin 4.1019056647
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.0919015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.1318220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0717292933
MESH:D011471 Prostatic Neoplasms Genistein 2.0715378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms Quercetin 2.0717292933 14715546
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0716039940
MESH:D011472 Prostatitis vinclozolin 5.1318629315
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.5514606601
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.3416849425
MESH:D012554 Schistosomiasis japonica Quercetin 5.7616862918
MESH:D012871 Skin Diseases Ascorbic Acid 3.2418709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.9119755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 5.9118572023 19524636
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9012854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013276 Stomach Ulcer Ascorbic Acid 4.0318726076
MESH:D020521 Stroke Ascorbic Acid 4.4016517955 16403987
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.991399818 6582329 6587162 7505956 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.368074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.3617053015
MESH:D001749 Urinary Bladder Neoplasms Quercetin 12.3616720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.3611723127 16452187 16712894 17306315
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9011813266
MESH:D014652 Vascular Diseases sodium arsenite 4.6217056641
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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