AutismKB 2.0

Annotation Detail for FOXN3


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Basic Information Top
Gene Symbol:FOXN3 ( C14orf116,CHES1,PRO1635 )
Gene Full Name: forkhead box N3
Band: 14q31.3-q32.11
Quick LinksEntrez ID:1112; OMIM: 602628; Uniprot ID:FOXN3_HUMAN; ENSEMBL ID: ENSG00000053254; HGNC ID: 1928
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1848Embryoma
2022Liver cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of FOXN3 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FOXN3 mRNAdecreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FOXN3 mRNAdecreases expression 20018196
19150397
C006780 bisphenol A bisphenol A results in increased expression of FOXN3 mRNAincreases expression 20678512
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of FOXN3 mRNAincreases expression 16934159
D005472 Fluorouracil Fluorouracil results in decreased expression of FOXN3 proteindecreases expression 15352031
D005472 Fluorouracil FOXN3 protein affects the susceptibility to Fluorouracilaffects response to substance 15352031
D008727 Methotrexate FOXN3 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D015735 Mifepristone Mifepristone results in increased expression of FOXN3 mRNAincreases expression 17584828
C059514 resveratrol resveratrol results in decreased expression of FOXN3 mRNAdecreases expression 12569576
D013629 Tamoxifen Tamoxifen results in increased expression of FOXN3 mRNAincreases expression 15849065
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FOXN3 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7614745880
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 9.2512039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.2514514962 11752688 15322242
MESH:D058186 Acute Kidney Injury resveratrol 3.9916538975
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5120464547 20127859
MESH:D000230 Adenocarcinoma Fluorouracil 4.5117638652
MESH:D000236 Adenoma Benzo(a)pyrene 7.066695378
MESH:D000236 Adenoma resveratrol 7.0615688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000544 Alzheimer Disease resveratrol 2.5916162502 16183991
MESH:D000740 Anemia Fluorouracil 9.1217963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.1211748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001169 Arthritis, Experimental resveratrol 3.5817115116
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1217286800
MESH:D050197 Atherosclerosis resveratrol 3.3516873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001862 Bone Resorption bisphenol A 4.0011985600
MESH:D002545 Brain Ischemia resveratrol 4.4817600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.8520146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 3.8517123778
MESH:D001943 Breast Neoplasms Fluorouracil 3.8516110121 15136595 16557594 19217205 18357371 18608205 16595493
MESH:D001943 Breast Neoplasms Methotrexate 3.8516978400
MESH:D001943 Breast Neoplasms resveratrol 3.8517534123 17651959 16393696
MESH:D001943 Breast Neoplasms Tamoxifen 3.8519288272 11161223 18997820 18815881 19487384 16202921 17261762 19410462 19103187 19221464 21152245 19189212 19200415 18351453 17049068 15565566 19066611 19115204 18984771 20135344 20005174 15668708 18425577 19189210 16818667 19142967 20859285 20544844 20065188 19084267 20390343 17893378 16873071 21138602 19289846 18855134 17242785 19011961 17440819 18629630 18821012 19244106 19059307 16273361 19155303
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.8520435547
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8916051944
MESH:D002277 Carcinoma Fluorouracil 8.5617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.5616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6819066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.753084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.7517045692 17088986 16799960 18930000 16332177 17971768
MESH:D006528 Carcinoma, Hepatocellular resveratrol 6.7516227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.7516924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.1817123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.7816675471
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0718695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.8020419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.8016757204 16280240 17066447 18986760
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.8016227395
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases resveratrol 3.5715458977
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8220889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515668235 15340226 12621046 8697196 16354765
MESH:D003092 Colitis resveratrol 4.3016474422
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9916510598 17169374 17725105 17172411 16340194 18772588 15001691 17287894 17016597 17018589
MESH:D003110 Colonic Neoplasms resveratrol 3.9916338953
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.7118509181 16331619 16524972 14970324 16303861 18949393 20501625 17255274 17695437 17094418 18383874 17594712 17401013 17016601 15148649 18448328 17454858 16282729 18802399 18288408 16391804 15289873
MESH:D015179 Colorectal Neoplasms resveratrol 2.7116550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.8416507316
MESH:D019465 Craniofacial Abnormalities Methotrexate 2.7912039119 9562676
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7920055451 10048152 15322242
MESH:D003550 Cystic Fibrosis Methotrexate 4.3719747007
MESH:D007644 Darier Disease Fluorouracil 4.9916733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5419031437
MESH:D003882 Dermatomyositis Methotrexate 5.2920191521
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.8916873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies resveratrol 9.4616286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.4619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4715619225 19739265 10663392 19085960 19420014 17522070 16485898 17906064 11529661 15968718 18713872 16227642 12392966 16109766 11743745 14725611 16393943 16177239 11739529 11461765 12153990 10915739 12540782 12705907 10774834 18071297 14550746 19416960 19370779 11421492 17562736 11287661 19164858 12958197 19923254 16081117 2444490 11834606 12594235 16781746 14986274
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 6.4717851650
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema resveratrol 7.338985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1216714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 9.8017872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.8019031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1320544844 16202921 17893378 19155303
MESH:D004715 Endometriosis Mifepristone 9.5916134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.599294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.0217923197
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.4216530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.4215173087 16785472 16337965 17638652 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Tamoxifen 3.3019224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1220067830
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005910 Glioma Fluorouracil 2.9216145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006086 Graft vs Host Disease Methotrexate 5.3216518429
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4818337622 15102660 15162350
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6711294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 16120746 12621046
MESH:D006561 Herpes Simplex resveratrol 4.3716876885
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2618606429 8697196 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006937 Hypercholesterolemia resveratrol 4.1417188708
MESH:D006949 Hyperlipidemias resveratrol 4.1816873680
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518670907 18850075
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.4317488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.8217600658
MESH:D007249 Inflammation resveratrol 8.7316366677
MESH:D007249 Inflammation Tamoxifen 8.7319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.7312878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.7616624496
MESH:D007333 Insulin Resistance bisphenol A 3.3816393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2712587719 15629191
MESH:D007680 Kidney Neoplasms Fluorouracil 7.9016985049
MESH:D007680 Kidney Neoplasms Tamoxifen 7.9018625569
MESH:D007805 Language Development Disorders Methotrexate 5.259562676
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.6616087638
MESH:D008064 Lipidoses Tamoxifen 3.2517567588 15342952
MESH:D008103 Liver Cirrhosis Methotrexate 3.7714986274
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3212878042
MESH:D008107 Liver Diseases Acetaminophen 1.6611587558 16610002 19014921 12587719 19460945 16611625 19784758 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3717185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.7720195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 14.7717045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms resveratrol 14.7719812893 20405173 19073162 19321006
MESH:D008113 Liver Neoplasms Tamoxifen 14.7716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.7716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1912151625
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.2418516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.956695378 18816296 20869020 18569708 20064080 20464547 20135361 18520028 17053015
MESH:D008175 Lung Neoplasms Fluorouracil 4.9515246190
MESH:D008175 Lung Neoplasms Tamoxifen 4.9518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9519555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9915086387
MESH:D008223 Lymphoma Methotrexate 4.0517352296
MESH:D016393 Lymphoma, B-Cell resveratrol 4.4517088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.9914749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 10.6615688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 10.6619428831
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.468985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.4619196723 14580682 16827153 11731420 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.7619453300
MESH:D008545 Melanoma resveratrol 3.5117992120
MESH:D008545 Melanoma Tamoxifen 3.5112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008659 Metabolic Diseases resveratrol 4.5217112576
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.8916381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.8916757204 18986760
MESH:D052016 Mucositis Methotrexate 5.4717488658
MESH:D009101 Multiple Myeloma resveratrol 3.5617049120 17164350 16490592 16267019 17935668 14749477
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.0617962980
MESH:D009203 Myocardial Infarction resveratrol 3.0816456233 16525036 17015251 17188708 17125593 16317513
MESH:D017202 Myocardial Ischemia resveratrol 9.3917125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.3912213967
MESH:D009205 Myocarditis resveratrol 4.9517322642
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2811141357
MESH:D009369 Neoplasms Fluorouracil 5.2816928823 18600527 18239605
MESH:D009374 Neoplasms, Experimental resveratrol 4.178985016
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2219189210 19200415 19196722
MESH:D009421 Nervous System Malformations bisphenol A 10.1316427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1314600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.7518514411
MESH:D019636 Neurodegenerative Diseases resveratrol 8.7517652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.5517929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5316436463
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.4117513867
MESH:D010049 Ovarian Diseases bisphenol A 5.1811985600
MESH:D010051 Ovarian Neoplasms Mifepristone 3.1616525653
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7119003803 16500647 15113037 16929163
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 17.4810548101
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 17.4816679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.4811896295 11222880 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3520887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8617292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8616740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8618626508 19082440
MESH:D011471 Prostatic Neoplasms resveratrol 1.8617804756 16731767 17675339 15767336 17636462 17718901
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8615067354
MESH:D011565 Psoriasis Methotrexate 3.4717410198
MESH:D011629 Puberty, Precocious bisphenol A 4.9810548101
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1415538739 16160472 18722050 18286688
MESH:D051437 Renal Insufficiency Methotrexate 4.8917352296
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.8016325855
MESH:D015427 Reperfusion Injury resveratrol 3.3316314181 17520802 16317513 15827377 17058453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.8010029692 19755658
MESH:D012878 Skin Neoplasms resveratrol 9.808985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.8016192470
MESH:D013088 Spermatocele Tamoxifen 4.5116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2319457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4520155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4516951190 17522103 19015929 16424979 18396642 17498489 15786421 18567086 17172411 19084572
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.6116321402
MESH:D019966 Substance-Related Disorders bisphenol A 4.1816684133 16045194
MESH:D013576 Syndactyly Methotrexate 5.209562676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D014062 Tongue Neoplasms Fluorouracil 10.4316280240
MESH:D014062 Tongue Neoplasms resveratrol 10.4316227395
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1617053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.168653321 17572228 16712894
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 10.0516803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 10.0517473185
MESH:D014591 Uterine Diseases bisphenol A 5.2314652134
MESH:D014594 Uterine Neoplasms resveratrol 4.3017044934
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.4817488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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