AutismKB 2.0

Annotation Detail for FAF1


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Basic Information Top
Gene Symbol:FAF1 ( FLJ37524,HFAF1s,UBXD12,UBXN3A,hFAF1 )
Gene Full Name: Fas (TNFRSF6) associated factor 1
Band: 1p32.3
Quick LinksEntrez ID:11124; OMIM: 604460; Uniprot ID:FAF1_HUMAN; ENSEMBL ID: ENSG00000185104; HGNC ID: 3578
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00020FAS signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1841Stomach cancer
Desease Name
CANCER
acute myeloid leukemia
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of FAF1 mRNAaffects expression 16917068
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene results in decreased expression of FAF1 mRNAdecreases expression 16917068
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of FAF1 mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of FAF1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FAF1 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of FAF1 mRNAaffects expression 17331233
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FAF1 mRNAdecreases expression 20106945
20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FAF1 mRNAdecreases expression 20382639
D016572 Cyclosporine Cyclosporine results in increased expression of FAF1 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of FAF1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FAF1 mRNAaffects cotreatment|increases expression 17942748
D017313 Fenretinide Fenretinide results in decreased expression of FAF1 mRNAdecreases expression 16570282
C116926 rofecoxib rofecoxib affects the expression of FAF1 mRNAaffects expression 17070997
D018038 Sodium Selenite Sodium Selenite results in increased expression of FAF1 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FAF1 mRNAaffects cotreatment|increases expression 17942748
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of FAF1 mRNAincreases expression 16137721
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9614514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.2520464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.2514692618
MESH:D000230 Adenocarcinoma Fenretinide 7.2510697514
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.6615814487
MESH:D000236 Adenoma Benzo(a)pyrene 2.706695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.8315885639
MESH:D001169 Arthritis, Experimental rofecoxib 7.8316690336
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.2019898480
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001932 Brain Neoplasms Fenretinide 4.4316187019
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9220146248 17474063
MESH:D001943 Breast Neoplasms Fenretinide 1.9216601279
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7916705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7912907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 4.7916270382 17159502
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.4511212258
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.8720419170
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 7.8716274795
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 7.8711212258
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4116120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.7412371664
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.5916154183
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Cyclosporine 7.9819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9816105132 17333356 17110522 15861022 16919318 11677210 17681005
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.138697196 15340226 15668235 12621046 16354765
MESH:D003110 Colonic Neoplasms rofecoxib 3.3112902858
MESH:D015179 Colorectal Neoplasms Fenretinide 2.6817273769
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1218551238
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8516285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.3418551238 21346803
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.3415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0416714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D004715 Endometriosis rofecoxib 9.5915652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.5910568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4120426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Cyclosporine 7.8519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.8515345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Cyclosporine 8.8312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8320067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D005909 Glioblastoma Fenretinide 3.9416187019
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5810048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0015340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816354765 18606429 15340226 8697196 16959395
MESH:D006973 Hypertension Cyclosporine 5.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3812200463 12878042
MESH:D007249 Inflammation Tobacco Smoke Pollution 5.3818590791
MESH:D007333 Insulin Resistance Sodium Selenite 3.3314714311
MESH:D007410 Intestinal Diseases rofecoxib 5.1415831440
MESH:D007417 Intestinal Polyps rofecoxib 5.4611245490
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Cyclosporine 2.388314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.5016705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5012371664
MESH:D007972 Leukoplakia, Oral Fenretinide 6.1816707609
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 2.7917565644
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.7912878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.5515890375 18177683 9163691 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.5521137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.978603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9712151625
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.1317365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.9414755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9418816296 20869020 18569708 20135361 20464547 18520028 6695378 20064080 17053015
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9411884234 19555203
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 4.9416288123 12111688 11091918 3440675
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1514737004
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 3.6210697514
MESH:D008545 Melanoma Fenretinide 2.8416270382
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2116966607 16166281 18303189
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 14.9316381670
MESH:D009062 Mouth Neoplasms Fenretinide 14.9316274795
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 14.9315006635
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9718551238
MESH:D009369 Neoplasms Benzo(a)pyrene 5.4411141357
MESH:D009369 Neoplasms Fenretinide 5.4415958647 17353921
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3619348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.8016303764
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5016049721 12819281
MESH:D010003 Osteoarthritis rofecoxib 4.4216690336
MESH:D010051 Ovarian Neoplasms Fenretinide 3.2516133793
MESH:D010149 Pain, Postoperative rofecoxib 5.5216678543 18165598
MESH:D010190 Pancreatic Neoplasms Fenretinide 3.3715580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.0010923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111118676 11399792 11222880 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6617292933
MESH:D011471 Prostatic Neoplasms Fenretinide 2.6617024972
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6618760546
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0617365031 17975199 17322281 15814490
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.7318410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012162 Retinal Degeneration Fenretinide 4.4616303925
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5818551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.9319755658 10029692
MESH:D012878 Skin Neoplasms Fenretinide 13.9316467112
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.9316192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 13.9318590791
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.2616049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.2617053015
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 12.2616720286
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 12.2612846360
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4310091137
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 4.6416154183
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27976
    • No data
    Releated disease ID Related disease Name
    PA443815Crohn Disease
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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