Annotation Detail for POLR3A
Basic Information Top
| Gene Symbol: | POLR3A ( RPC1,RPC155,hRPC155 ) |
|---|---|
| Gene Full Name: | polymerase (RNA) III (DNA directed) polypeptide A, 155kDa |
| Band: | 10q22.3 |
| Quick Links | Entrez ID:11128; OMIM: NA; Uniprot ID:RPC1_HUMAN; ENSEMBL ID: ENSG00000148606; HGNC ID: 30074 |
| Relate to Another Database: | SFARIGene; denovo-db |
Related Diseases/Disorders| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D002995 | Clofibric Acid | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of POLR3A mRNA | affects cotreatment|affects expression | 17602206 |
| D004052 | Diethylnitrosamine | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of POLR3A mRNA | affects cotreatment|affects expression | 17602206 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000236 | Adenoma | Diethylnitrosamine | 3.10 | 10737359 6695378 | |
| MESH:D018248 | Adenoma, Liver Cell | Diethylnitrosamine | 4.79 | 17162532 19052882 16434500 17620307 19061943 18056438 | |
| MESH:D001943 | Breast Neoplasms | Diethylnitrosamine | 2.18 | 17474063 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Diethylnitrosamine | 1.88 | 19052882 17428255 19822196 19335982 18506893 10672840 18393292 18691550 16328049 16698587 16502159 16779866 21159647 20432363 17173139 18785209 17761372 19107877 19171122 19519916 17978847 19383236 18788625 3581430 17138121 17055752 16288022 20935162 20514400 19919837 19539802 18971187 3084413 19418558 16878318 18056438 19701751 16681979 20727157 17162532 20524982 10737359 18210153 20101231 20007298 20512989 19208518 18978308 18665156 16540662 11831363 16569478 19394651 18494052 20214788 16830150 16807293 16935385 20084675 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Diethylnitrosamine | 3.18 | 17174075 7505956 21159647 2727394 | |
| MESH:D018281 | Cholangiocarcinoma | Diethylnitrosamine | 4.15 | 19052882 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Diethylnitrosamine | 2.27 | 20387270 | |
| MESH:D056486 | Drug-Induced Liver Injury | Diethylnitrosamine | 2.15 | 19107877 | |
| MESH:D004931 | Esophageal Achalasia | Diethylnitrosamine | 6.19 | 16302075 | |
| MESH:D005234 | Fatty Liver | Diethylnitrosamine | 3.73 | 20387270 21071580 | |
| MESH:D007249 | Inflammation | Diethylnitrosamine | 2.59 | 18785209 | |
| MESH:D008103 | Liver Cirrhosis | Diethylnitrosamine | 3.05 | 19638242 20032147 18665156 18522880 18407596 | |
| MESH:D008107 | Liver Diseases | Diethylnitrosamine | 2.18 | 17034775 | |
| MESH:D008113 | Liver Neoplasms | Clofibric Acid | 5.25 | 17602206 | |
| MESH:D008113 | Liver Neoplasms | Diethylnitrosamine | 5.25 | 18648771 19090486 20137499 10737359 18754104 9163691 16942905 19996281 19812893 19850985 20101389 19833225 20452335 18977376 19427195 15885732 19254457 20118626 12112319 21071580 21278145 19642983 19426721 2422723 12771043 20405173 19294768 18978307 19638242 20583210 15175105 2862719 19690152 20492335 18644402 19073162 19499222 19256749 19551842 20434301 21167192 20501860 19255062 21047994 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Diethylnitrosamine | 2.90 | 18079962 18282651 19009564 18308698 18253720 21159647 18544905 2563599 18164116 17854601 18775883 9362446 19126423 17174075 19539802 16842330 16267830 18093689 3124819 19519916 17942915 19004024 | |
| MESH:D008175 | Lung Neoplasms | Diethylnitrosamine | 1.77 | 21163286 6695378 20970405 20512841 | |
| MESH:D009362 | Neoplasm Metastasis | Diethylnitrosamine | 2.72 | 9029167 3581430 | |
| MESH:D019636 | Neurodegenerative Diseases | Diethylnitrosamine | 3.78 | 20387270 | |
| MESH:D009461 | Neurologic Manifestations | Diethylnitrosamine | 6.19 | 20387270 | |
| MESH:D010190 | Pancreatic Neoplasms | Diethylnitrosamine | 2.55 | 16540662 | |
| MESH:D011230 | Precancerous Conditions | Diethylnitrosamine | 4.02 | 2563599 | |
| MESH:D013274 | Stomach Neoplasms | Diethylnitrosamine | 1.76 | 18456281 | |
| MESH:D013964 | Thyroid Neoplasms | Diethylnitrosamine | 3.36 | 7505956 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:04623 | Cytosolic DNA-sensing pathway |
| KEGG:01100 | Metabolic pathways |
| KEGG:00230 | Purine metabolism |
| KEGG:00240 | Pyrimidine metabolism |
| KEGG:03020 | RNA polymerase |
| REACT:1788 | Transcription |