AutismKB 2.0

Annotation Detail for CAPN10


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Basic Information Top
Gene Symbol:CAPN10 ( CANP10,NIDDM1 )
Gene Full Name: calpain 10
Band: 2q37.3
Quick LinksEntrez ID:11132; OMIM: 605286; Uniprot ID:CAN10_HUMAN; ENSEMBL ID: ENSG00000142330; HGNC ID: 1477
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
No data
Pathway IDPathway Name
P00029Huntington disease
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Metabolic diseases
Diabetes
H00409Type II diabetes mellitus
Desease IDDesease Name
1856Obesity
1903Larynx cancer
1904Diabetes mellitus
1918Atherosclerosis
2091Hypertension
2040Hyperglycemia
2053Colon cancer
2102Polycystic ovary syndrome
Desease Name
reduced muscle mRNA levels and insulin resistance
Hirsutism
glucose
polycystic ovary syndrome
CARDIOVASCULAR
Metabolic Syndrome X
microvascular function
hemoglobin A(1c)
CANCER
laryngeal cancer
body mass
polycystic ovarian syndrome
glucose metabolism
nephropathy, diabetic
hypertension
reduced beta(3)-adrenoceptor function
C-peptide
METABOLIC
triglycerides
obesity
insulin
REPRODUCTION
diabetes, type 2
fatty acid
Insulin Resistance
No data
Desease Name
Diabetes mellitus, noninsulin-dependent 1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CAPN10 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of CAPN10 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of CAPN10 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of CAPN10 mRNAincreases expression 15761015
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CAPN10 mRNAaffects cotreatment|affects expression 17602206
D004041 Dietary Fats Dietary Fats results in decreased expression of CAPN10 mRNAdecreases expression 18503570
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CAPN10 mRNAaffects cotreatment|affects expression 17602206
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CAPN10 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of CAPN10 mRNAincreases expression 18301758
D014212 Tretinoin Tretinoin results in increased expression of CAPN10 mRNAincreases expression 17218384
D019287 Zinc Sulfate Zinc Sulfate results in decreased expression of CAPN10 mRNAdecreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Zinc Sulfate 5.147265320
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3211798837 19825857
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.983712494
MESH:D000236 Adenoma Diethylnitrosamine 6.986695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.9018056438 19052882 16434500 19061943 17162532 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.9016434500
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D000860 Anoxia Zinc Sulfate 5.267265320
MESH:D001161 Arteriosclerosis Dietary Fats 4.1015238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.1816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2811289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 16.3916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.3919483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 16.3916206674 16197459
MESH:D001943 Breast Neoplasms Dietary Fats 1.9120435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9117474063
MESH:D001943 Breast Neoplasms Tretinoin 1.9116873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.7216705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.727296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.723084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.7215073043 16217749 11135700 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.7218494052 19701751 16328049 19539802 20512989 19519916 20101231 11831363 18691550 20524982 18210153 16807293 20727157 19171122 19208518 17173139 18665156 18785209 20432363 16288022 18393292 17761372 18788625 17138121 16935385 17978847 20214788 19394651 16878318 18506893 10737359 20084675 16681979 16779866 16502159 16698587 17162532 21159647 19418558 20007298 19052882 16830150 17055752 16540662 19383236 20935162 18971187 18056438 20514400 17428255 19107877 19335982 10672840 3581430 19919837 18978308 3084413 19822196 16569478
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.721917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3316051514 16096774
MESH:D002386 Cataract Acetaminophen 7.5410977129
MESH:D002386 Cataract Tretinoin 7.5417460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.087505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.0821159647 7505956 17174075 2727394
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8419052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.2719486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.2719176532
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D002972 Cleft Palate Tretinoin 2.739407595
MESH:D003092 Colitis Tretinoin 3.9217035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7210525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.729224671 10589399 9211117 14991402 9142499 17551590 8800419 9664655 16925845 9125849
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.018970840 14531868 11298694 2524372 8156756 11906362 18759878 12868966
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.673621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 marker/mechanism
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.3521346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.356679447 16192314 9022650 1440618 11289319 7440962 6482804 18289764 9328219 18648102 9653073 18692083 8291058
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3519739265 19923254 11287661 11421492 16177239 15968718 14986274 12594235 17906064 2444490 11834606 12392966 16227642 19164858 12958197 16393943 16109766 17522070 16081117 15619225 19085960 19420014 10915739 14550746 19416960 18713872 11529661 11461765 14725611 16485898 16781746 11739529 11743745 19370779 12153990 17562736 12540782 10663392 10774834 12705907 18071297
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.3519107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004489 Edema, Cardiac Tretinoin 4.7318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2116569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3816302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.603581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6012903497
MESH:D005124 Eye Abnormalities Tretinoin 3.709664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 20.2615073043
MESH:D005234 Fatty Liver Dietary Fats 20.2619551842 18296743 19004024 17967931
MESH:D005234 Fatty Liver Diethylnitrosamine 20.2620387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 20.2620131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Dietary Fats 9.5618296743
MESH:D005355 Fibrosis Tretinoin 9.5617994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005909 Glioblastoma Tretinoin 3.1117312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.989664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 5.2117063115
MESH:D006529 Hepatomegaly pirinixic acid 3.2118467677 16221962 19176532 19772884
MESH:D006930 Hyperalgesia Acetaminophen 8.0916870215
MESH:D006930 Hyperalgesia Tretinoin 8.0916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D007022 Hypotension Zinc Sulfate 4.657265320
MESH:D007249 Inflammation Dietary Fats 5.3820412841
MESH:D007249 Inflammation Diethylnitrosamine 5.3818785209
MESH:D007333 Insulin Resistance Dietary Fats 7.6111836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.6116306350
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.289022650 8074119
MESH:D007569 Jaw Abnormalities Tretinoin 4.0715992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 2.2912587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.8416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.846582329
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.4115237267
MESH:D007938 Leukemia arsenic trioxide 6.6015070760
MESH:D007938 Leukemia Tretinoin 6.6017143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9712560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 10.0519077051
MESH:D007951 Leukemia, Myeloid Tretinoin 10.0516482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9719850784 20471514 16467208 17050201 16968895
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9716294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.9919642359 16112521 17712046 19035177 17217047 16823087 12018890 17649720 12712474 9834237 16330433 16891316 17107899 11468182 12679006 15213294 15748426 15622746 11161223 19075265 19225113 16966277 15336539 17869043 16331271
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.9919642359 17506722 19035177 17301526 9834237 17217047 16788101 19029980 19075265 16891316 17339181 16140955 16766008 12679006 17368321 17361223 17712046 17649720 17107899 16823087 16331271 16935935 15748426 17294898 19225113
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008103 Liver Cirrhosis Dietary Fats 6.9318296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.9320032147 18407596 18522880 18665156 19638242
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3915474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3916248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 4.0312969438 19014921 19784758 12587719 16611625 11587558 19460945 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0317034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 11.2114682389
MESH:D008113 Liver Neoplasms Clofibric Acid 11.2117602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.2118978307 19073162 19551842 15885732 20118626 20583210 19090486 19256749 20434301 19255062 18644402 16942905 20101389 19996281 2422723 19427195 18648771 19833225 19850985 9163691 19294768 21047994 18754104 21071580 18977376 21167192 20501860 19642983 15175105 2862719 19254457 20137499 20452335 19426721 19690152 19638242 10737359 20492335 12771043 19812893 12112319 20405173 21278145 19499222
MESH:D008113 Liver Neoplasms pirinixic acid 11.2120007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.47598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.4720377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.4717942915 17854601 18164116 18079962 18253720 19539802 18544905 21159647 18093689 18775883 18282651 2563599 19519916 19009564 3124819 16267830 18308698 19004024 9362446 17174075 16842330 19126423
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.5319825857 11798837
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.5320512841 20970405 21163286 6695378
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2219549372 15949261 11468182 14977855 19417148
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.6916882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.6917596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.903581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.903581430 9029167
MESH:D009369 Neoplasms pirinixic acid 5.1717405874
MESH:D009369 Neoplasms Tretinoin 5.1716946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 3.989125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.766679447
MESH:D009436 Neural Tube Defects arsenic trioxide 12.7610525206
MESH:D009436 Neural Tube Defects Tretinoin 12.769142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.6718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.6720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3820387270
MESH:D009765 Obesity Dietary Fats 4.5619632207 21332399 18674790 20132043 20518802 17217161 18457598 11836018 16723640
MESH:D009765 Obesity pirinixic acid 4.5620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4316049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.434026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.0316624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0316936753
MESH:D010146 Pain Acetaminophen 7.0716870215
MESH:D010146 Pain Tretinoin 7.0716870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.9315580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.9316540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.9315976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.702563599
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2419131511
MESH:D011507 Proteinuria Tretinoin 3.7916636307
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2816116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6418551238
MESH:D012878 Skin Neoplasms Tretinoin 2.6816467112
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4417007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.4418456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.4417261132
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 18.216582329 1399818 6587162 7505956 3712494
MESH:D013964 Thyroid Neoplasms arsenic trioxide 18.2119014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 18.217505956
MESH:D013964 Thyroid Neoplasms Tretinoin 18.2116026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.6616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.668074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.6611780464 20435036 12845720 12973940
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26058
    • No data
    Releated disease ID Related disease Name
    PA443890Diabetes Mellitus, Type 2
    PA443886Diabetes Mellitus
    PA133888799Organ Transplantation
    PA134850491Transplantation
    PA444626Insulin Resistance
    Releated drug ID Related drug Name
    PA10390sulfonamides, urea derivatives
    PA451578tacrolimus
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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