AutismKB 2.0

Annotation Detail for CHGB


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Basic Information Top
Gene Symbol:CHGB ( SCG1 )
Gene Full Name: chromogranin B (secretogranin 1)
Band: 20p12.3
Quick LinksEntrez ID:1114; OMIM: 118920; Uniprot ID:SCG1_HUMAN; ENSEMBL ID: ENSG00000089199; HGNC ID: 1930
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2091Hypertension
2198Psychotic disorder
Desease Name
PSYCH
schizophrenia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CHGB mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of CHGB mRNAincreases expression 15761015
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of CHGB mRNAincreases expression 17452286
D003976 Diazinon Diazinon results in decreased expression of CHGB mRNAdecreases expression 18812211
D003976 Diazinon Diazinon results in increased expression of CHGB mRNAincreases expression 17452286
D004026 Dieldrin Dieldrin results in decreased expression of CHGB mRNAdecreases expression 18812211
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CHGB mRNAaffects cotreatment|increases expression 17942748
D005038 Ethylnitrosourea Ethylnitrosourea results in increased expression of CHGB mRNAincreases expression 15954086
D005419 Flavonoids Flavonoids results in increased expression of CHGB mRNAincreases expression 18035473
C015329 lycopene lycopene results in decreased expression of CHGB mRNAdecreases expression 16886892
D009532 Nickel Nickel results in increased expression of CHGB mRNAincreases expression 18812211
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CHGB mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D055371 Acute Lung Injury Nickel 4.7316166738
MESH:D000230 Adenocarcinoma arsenic trioxide 4.3919825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3914692618
MESH:D000236 Adenoma Ethylnitrosourea 3.796695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 9.8311874814 16611668 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 9.8316487989
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.4316206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001927 Brain Diseases Ethylnitrosourea 5.0114991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.4218412241 16357521 15144691 16651633 16436596
MESH:D001943 Breast Neoplasms Dieldrin 2.1215770527 11859874
MESH:D001943 Breast Neoplasms Nickel 2.1215986119
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1220435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4811589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 1.9616217749 11135700 14691202 15073043 15553829
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2512490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.8216003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.2017160924
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9817333356 15861022 11677210 16105132 17110522 16919318 17681005
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1512621046 15340226 16354765 8697196 15668235
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5110525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5120055451 10048152 15322242
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2415213294
MESH:D017449 Dermatitis, Allergic Contact Nickel 4.1219470301 17100760 17244072
MESH:D003877 Dermatitis, Contact Nickel 4.782952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004417 Dyspnea Diazinon 5.0216487989
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.2018357618
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3412903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver arsenic trioxide 8.2115073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.2115345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1220067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4216904648
MESH:D005909 Glioblastoma Ethylnitrosourea 3.9216436596
MESH:D005910 Glioma Ethylnitrosourea 3.5418412241 16357521 16651633
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4010048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis Diazinon 4.7316487989
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0716120746 15340226 12621046
MESH:D015658 HIV Infections Nickel 3.8817263646
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616959395 8697196 18606429 16354765 15340226
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816569931 16945680
MESH:D007247 Infertility, Female Dieldrin 10.8010630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 10.8012013081
MESH:D007248 Infertility, Male Diazinon 7.2512948887 16466525
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.2517937319
MESH:D007249 Inflammation Flavonoids 8.8517296493
MESH:D007249 Inflammation Nickel 8.8516166738
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.8512200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 4.0517379185
MESH:D007938 Leukemia arsenic trioxide 2.8915070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9317077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1619850784 20471514 16968895 17050201 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3011161223 12712474 12679006 17649720 16331271 17712046 15622746 19642359 17869043 16891316 16330433 15213294 15336539 9834237 16966277 17107899 19225113 16823087 15748426 16112521 19075265 19035177 11468182 12018890 17217047
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5116882451
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Chlorpyrifos 3.1015991261
MESH:D008113 Liver Neoplasms arsenic trioxide 7.8414682389
MESH:D008113 Liver Neoplasms Dieldrin 7.849539021 8742319
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8416984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.0820377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0812151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5811798837 19825857
MESH:D008175 Lung Neoplasms Ethylnitrosourea 3.5816019985 6695378 16271038 17703301
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5819555203 11884234
MESH:D008223 Lymphoma Ethylnitrosourea 4.0415790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.2215375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.5910838139 18041768 10767621
MESH:D008579 Meningioma Ethylnitrosourea 6.2017943659
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2015949261 11468182 14977855 19549372 19417148
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2216882451 16105982
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1216624393
MESH:D009369 Neoplasms Dieldrin 6.178820588
MESH:D009369 Neoplasms lycopene 6.1717051425
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.5816707424
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2010525206
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.6116003739 16651423 17160924
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.2615081274
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.2017160924
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4416624393 19769630 12452020
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5715580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010235 Paraganglioma arsenic trioxide 4.3119927285
MESH:D010300 Parkinson Disease Dieldrin 3.5716112328 17291500 11181820 11445065 16809432
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D011041 Poisoning Diazinon 4.5017603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811399792 11118676 11222880 11896295
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.7219131511
MESH:D011471 Prostatic Neoplasms lycopene 3.7215084515 17337101
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.8117119214 11874814 16611668
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.1116611668 17119214
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1216646077
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.316418539
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.3515790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1515213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5312845720 20435036 11780464 12973940
MESH:D014570 Urologic Diseases Diazinon 5.4916487989
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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