AutismKB 2.0

Annotation Detail for DMC1


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Basic Information Top
Gene Symbol:DMC1 ( DMC1H,HsLim15,LIM15,MGC150472,MGC150473,dJ199H16.1 )
Gene Full Name: DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)
Band: 22q13.1
Quick LinksEntrez ID:11144; OMIM: 602721; Uniprot ID:DMC1_HUMAN; ENSEMBL ID: ENSG00000100206; HGNC ID: 2927
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2121Ovarian failure
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C096920 AGN 193109 AGN 193109 inhibits the reaction [Tretinoin results in increased expression of DMC1 mRNA]decreases reaction|increases expression 16574651
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of DMC1 mRNAincreases expression 19152381
D001564 Benzo(a)pyrene chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of DMC1 mRNA]decreases reaction|increases expression 19152381
C006780 bisphenol A bisphenol A results in increased expression of DMC1 mRNAincreases expression 20739668
C007020 chlorophyllin chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of DMC1 mRNA]decreases reaction|increases expression 19152381
D007654 Ketoconazole Ketoconazole results in increased expression of DMC1 mRNAincreases expression 16574651
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of DMC1 mRNAincreases expression 12057914
D014212 Tretinoin AGN 193109 inhibits the reaction [Tretinoin results in increased expression of DMC1 mRNA]decreases reaction|increases expression 16574651
D014212 Tretinoin Tretinoin results in increased expression of DMC1 mRNAincreases expression 16574651
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.3318653653 11850527
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.2316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4116456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8916197459 16206674
MESH:D001862 Bone Resorption bisphenol A 4.1411985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9120146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 1.9117123778
MESH:D001943 Breast Neoplasms Tretinoin 1.9116443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.911917145
MESH:D002278 Carcinoma in Situ bisphenol A 5.3817123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7920419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.7916096774 16051514
MESH:D002386 Cataract Tretinoin 3.2417460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D002972 Cleft Palate Tretinoin 2.769407595
MESH:D003092 Colitis Tretinoin 4.0617035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8310589399 9224671 17551590 9142499 16925845 14991402 9664655 8800419 9211117 9125849
MESH:D056486 Drug-Induced Liver Injury Ketoconazole 3.5118289764
MESH:D004489 Edema, Cardiac Tretinoin 4.9118230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2816569247
MESH:D019446 Endotoxemia Lipopolysaccharides 4.7915821434 15328337 17637181
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005124 Eye Abnormalities Tretinoin 3.7816938888 9664655
MESH:D005334 Fever Lipopolysaccharides 4.2811852909 9205823
MESH:D005355 Fibrosis Tretinoin 3.8717994277
MESH:D005909 Glioblastoma Tretinoin 3.1717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.0920471113
MESH:D006330 Heart Defects, Congenital Tretinoin 7.0914991402 9664655
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.6516366002
MESH:D006930 Hyperalgesia Tretinoin 3.4316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D007249 Inflammation Lipopolysaccharides 2.9917963957 17237260 9205823 12878042 17255318
MESH:D007333 Insulin Resistance bisphenol A 3.4616393666
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.9317255318
MESH:D007569 Jaw Abnormalities Tretinoin 4.1815992940 17551590
MESH:D016773 Leishmaniasis, Cutaneous Ketoconazole 4.932166429 1311351 8889330 19744259
MESH:D007898 Leishmaniasis, Visceral Ketoconazole 4.7511332679
MESH:D007938 Leukemia Tretinoin 2.8917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1117596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3212679006 15748426 17506722 17368321 16140955 16331271 17217047 9834237 16891316 16766008 16788101 17712046 17361223 17294898 17339181 16935935 17107899 19029980 17301526 17649720 19035177 16823087 19225113 19642359 19075265
MESH:D007970 Leukopenia Lipopolysaccharides 5.0915821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008064 Lipidoses Ketoconazole 4.7617567588
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.7512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.7518397230 16248980
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1220195826 21137059
MESH:D055370 Lung Injury Lipopolysaccharides 4.3621114838
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5720464547 20064080 6695378 20869020 18816296 18520028 20135361 17053015 18569708
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2217596541
MESH:D009369 Neoplasms Benzo(a)pyrene 5.3911141357
MESH:D009369 Neoplasms Tretinoin 5.3916946489 16594593
MESH:D009421 Nervous System Malformations bisphenol A 10.9111399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 10.919125849
MESH:D009436 Neural Tube Defects Tretinoin 3.229142499
MESH:D010049 Ovarian Diseases bisphenol A 5.3811985600
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4116936753
MESH:D010146 Pain Tretinoin 3.1316870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5415976015
MESH:D011014 Pneumonia Lipopolysaccharides 4.9511605937 12224865
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.3510548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6917292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.6916740699
MESH:D011471 Prostatic Neoplasms Ketoconazole 2.6917404083
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D011629 Puberty, Precocious bisphenol A 5.1810548101
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.9010835634
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4016116481 16283617
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.0619755658 10029692
MESH:D012878 Skin Neoplasms Tretinoin 6.0616467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4020155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.4017261132
MESH:D019966 Substance-Related Disorders bisphenol A 4.3816045194 16684133
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.4315821434
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2317045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2617053015
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9416129372
MESH:D014591 Uterine Diseases bisphenol A 5.4514652134
MESH:D014604 Uveal Neoplasms Tretinoin 5.0516752155
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
Pathway ID Pathway Name
REACT:27271 Meiotic Recombination
REACT:27235 Meiotic Recombination (mouse)
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03366 - Imidazole Enzyme Inhibitors
DB03684 - 2-Methyl-2,4-Pentanediol
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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