AutismKB 2.0

Annotation Detail for CORO1A


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Basic Information Top
Gene Symbol:CORO1A ( CLABP,CLIPINA,FLJ41407,HCORO1,MGC117380,TACO,p57 )
Gene Full Name: coronin, actin binding protein, 1A
Band: 16p11.2
Quick LinksEntrez ID:11151; OMIM: 605000; Uniprot ID:COR1A_HUMAN; ENSEMBL ID: ENSG00000102879; HGNC ID: 2252
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of CORO1A mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CORO1A mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CORO1A mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of CORO1A proteinincreases expression 19364129
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CORO1A mRNAdecreases expression 20127859
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in increased expression of CORO1A mRNAincreases expression 15912405
C006780 bisphenol A bisphenol A results in increased expression of CORO1A mRNAincreases expression 18180321
C099555 CD 437 CD 437 results in increased expression of CORO1A mRNAincreases expression 12958071
D002635 Chenodeoxycholic Acid [Chenodeoxycholic Acid co-treated with Tretinoin] results in decreased expression of CORO1A mRNAaffects cotreatment|decreases expression 16040207
D002635 Chenodeoxycholic Acid Chenodeoxycholic Acid results in decreased expression of CORO1A mRNAdecreases expression 16040207
D004041 Dietary Fats Dietary Fats results in decreased expression of CORO1A mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CORO1A mRNAincreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CORO1A mRNAincreases expression 15834898
C008493 methylselenic acid methylselenic acid results in increased expression of CORO1A mRNAincreases expression 12517777
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of CORO1A mRNAincreases expression 17616710
C041786 palm oil palm oil results in decreased expression of CORO1A mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of CORO1A mRNAdecreases expression 17426115
D014212 Tretinoin [Chenodeoxycholic Acid co-treated with Tretinoin] results in decreased expression of CORO1A mRNAaffects cotreatment|decreases expression 16040207
D014212 Tretinoin Tretinoin results in increased expression of CORO1A mRNAincreases expression 17218384
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 3.977525203
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 7.0311798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.0320127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0314692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.656695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5016434500
MESH:D000505 Alopecia Tretinoin 3.6215955085
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0919183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.9515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.2115885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.2116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2616292516
MESH:D001249 Asthma Tretinoin 2.3416456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001471 Barrett Esophagus Tretinoin 4.4116935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.3916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.3919483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.3916206674 16197459
MESH:D001862 Bone Resorption bisphenol A 3.8711985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9620146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 1.9617123778
MESH:D001943 Breast Neoplasms Dietary Fats 1.9620435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9616166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6116813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3411589617
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1916168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.553084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.5515073043 14691202 11135700 16217749 15553829
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.551917145
MESH:D002278 Carcinoma in Situ bisphenol A 5.0117123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1212490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5720419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.5716096774 16051514
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 12.3814694615
MESH:D002386 Cataract Acetaminophen 12.3810977129
MESH:D002386 Cataract Tretinoin 12.3817460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6116129372
MESH:D002779 Cholestasis Ethinyl Estradiol 7.7511677210 17681005 15861022 17110522 17333356 16919318 16105132
MESH:D002779 Cholestasis pirinixic acid 7.7519176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1916461808
MESH:D002972 Cleft Palate Tretinoin 2.679407595
MESH:D003092 Colitis Tretinoin 3.7217035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.1615095906
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.6810525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.689142499 16925845 9211117 8800419 9125849 10589399 9224671 17551590 9664655 14991402
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1015213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 3.9621346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9612540782 10915739 11739529 11287661 19420014 12153990 12392966 17906064 11743745 19739265 12594235 10663392 19164858 19085960 16393943 10774834 15619225 19416960 11529661 17562736 14550746 16485898 18713872 16227642 19923254 11421492 2444490 16109766 19370779 14725611 18071297 12958197 14986274 16177239 16081117 11461765 12705907 15968718 11834606 17522070 16781746
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D050171 Dyslipidemias Dietary Fats 3.4518367378
MESH:D004487 Edema pirinixic acid 2.4912083418
MESH:D004489 Edema, Cardiac Tretinoin 4.5018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2012538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1116569247
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.3112903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.3116530937
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 7.3115547721 15264214 16805852 15623463 15150132 15547733 16704527 15878914 16510608
MESH:D005124 Eye Abnormalities Tretinoin 3.589664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 18.8115073043
MESH:D005234 Fatty Liver Dietary Fats 18.8119551842 17967931 18296743 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.8115345470
MESH:D005234 Fatty Liver pirinixic acid 18.8120131406 19236843
MESH:D005355 Fibrosis Dietary Fats 8.8818296743
MESH:D005355 Fibrosis Tretinoin 8.8817994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2716904648
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005909 Glioblastoma Tretinoin 3.0117312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1916084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6620471113
MESH:D006330 Heart Defects, Congenital Tretinoin 6.669664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006529 Hepatomegaly pirinixic acid 3.0119772884 16221962 18467677 19176532
MESH:D006930 Hyperalgesia Acetaminophen 7.6316870215
MESH:D006930 Hyperalgesia Tretinoin 7.6316870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6021332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.6221332399
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4917937319
MESH:D007249 Inflammation Dietary Fats 2.4320412841
MESH:D007333 Insulin Resistance bisphenol A 12.3516393666
MESH:D007333 Insulin Resistance Dietary Fats 12.3518457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 12.3516306350
MESH:D007410 Intestinal Diseases Tretinoin 3.7817994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.9017551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.2012587719 15629191
MESH:D007938 Leukemia arsenic trioxide 6.3415070760
MESH:D007938 Leukemia Tretinoin 6.3417143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.4919077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.4916482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.8816968895 16467208 17050201 20471514 19850784
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8819850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.6416966277 15622746 17217047 15213294 19225113 17649720 11161223 16823087 12679006 16891316 17869043 15336539 12018890 9834237 16330433 12712474 16331271 17712046 19642359 17107899 11468182 16112521 19035177 19075265 15748426
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.6417506722 17649720 15748426 17361223 16331271 17339181 19029980 16823087 16766008 19035177 17301526 16140955 19225113 19642359 17368321 9834237 12679006 17294898 16935935 16891316 19075265 17712046 16788101 17217047 17107899
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3616882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.319224671
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8818296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3415474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3418397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6316611625 19460945 16610002 19014921 19784758 12969438 11587558 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2417185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 7.4014682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.4021137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 7.4020007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.7320377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3515213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.4111798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4120464547 20869020 18816296 20064080 18569708 18520028 6695378 20135361 17053015
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma Tretinoin 1.9416752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008591 Meningomyelocele Tretinoin 4.4416940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1916381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1119417148 19549372 14977855 11468182 15949261
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.3916105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.3917596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9516411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9716624393
MESH:D009369 Neoplasms Benzo(a)pyrene 8.2011141357
MESH:D009369 Neoplasms pirinixic acid 8.2017405874
MESH:D009369 Neoplasms Tretinoin 8.2016594593 16946489
MESH:D009421 Nervous System Malformations bisphenol A 9.8216427766 11399458
MESH:D009421 Nervous System Malformations Tretinoin 9.829125849
MESH:D009436 Neural Tube Defects arsenic trioxide 7.3110525206
MESH:D009436 Neural Tube Defects Tretinoin 7.319142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D009765 Obesity Dietary Fats 4.4420518802 21332399 17217161 16723640 11836018 19632207 18674790 20132043 18457598
MESH:D009765 Obesity pirinixic acid 4.4420558911
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 4.1014694615
MESH:D010049 Ovarian Diseases bisphenol A 5.0111985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.0319769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms CD 437 8.0317474084
MESH:D010051 Ovarian Neoplasms Tretinoin 8.0316936753
MESH:D010146 Pain Acetaminophen 6.5916870215
MESH:D010146 Pain Tretinoin 6.5916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.2915580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.2915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010235 Paraganglioma arsenic trioxide 4.1719927285
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 3.9710548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.2120887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1019131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1017292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1016740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.1016205645
MESH:D011507 Proteinuria Tretinoin 3.6116636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D011625 Pterygium Tretinoin 4.8116723453
MESH:D011629 Puberty, Precocious bisphenol A 4.8110548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1116283617 16116481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9716646077
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6819755658 10029692
MESH:D012878 Skin Neoplasms Tretinoin 5.6816467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.7417007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.7420155912 2093021
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.7417575124 12958204
MESH:D013274 Stomach Neoplasms Tretinoin 4.7417261132
MESH:D019966 Substance-Related Disorders bisphenol A 4.0016045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.2119014326
MESH:D013964 Thyroid Neoplasms Tretinoin 7.2116026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.7916051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9815213294
MESH:D014376 Tuberculosis marker/mechanism 16040207
MESH:D014376 Tuberculosis Chenodeoxycholic Acid 8.5316040207
MESH:D014376 Tuberculosis Tretinoin 8.5316040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.4520435036 12973940 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.4517053015
MESH:D001749 Urinary Bladder Neoplasms CD 437 8.4516720286
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6816129372
MESH:D014591 Uterine Diseases bisphenol A 5.0414652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.6416752155
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.0716761959
MESH:D015430 Weight Gain Dietary Fats 3.7416723640
MESH:D009396 Wilms Tumor Tretinoin 3.9716287080
Pathway ID Pathway Name
KEGG:04145 Phagosome
KEGG:05152 Tuberculosis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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