AutismKB 2.0

Annotation Detail for FICD


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Basic Information Top
Gene Symbol:FICD ( HIP13,HYPE,MGC5623,UNQ3041 )
Gene Full Name: FIC domain containing
Band: 12q23.3
Quick LinksEntrez ID:11153; OMIM: NA; Uniprot ID:FICD_HUMAN; ENSEMBL ID: ENSG00000198855; HGNC ID: 18416
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of FICD mRNAincreases expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of FICD mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of FICD mRNAincreases expression 20106945
C106014 gedunin gedunin results in increased expression of FICD mRNAincreases expression 17010675
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of FICD mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FICD mRNAaffects binding|decreases expression|increases activity 19710929
D013629 Tamoxifen Tamoxifen results in increased expression of FICD mRNAincreases expression 15590111
C050414 tripterine tripterine results in increased expression of FICD mRNAincreases expression 17010675
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Estradiol 2.1511473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D001943 Breast Neoplasms Estradiol 2.0917289903 12948864 17018787 14630087 18497071 16675129 17261762 19861407
MESH:D001943 Breast Neoplasms Tamoxifen 2.0916273361 19487384 20135344 19189210 19103187 19142967 19244106 20544844 19059307 15565566 11161223 15668708 16818667 19115204 20859285 19221464 19066611 19189212 19288272 18815881 21138602 19155303 19289846 19084267 19200415 18629630 20005174 17049068 20065188 17893378 18984771 16202921 21152245 18855134 17261762 19011961 18997820 18351453 19410462 17440819 18821012 17242785 20390343 16873071 18425577
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.1416011737 15700767 16050911 15721981 16192424 16227642 10355542 15673190 16124888 18705752 3786805 16097048
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7818788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7816924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7816924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1912371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.1918566989
MESH:D002779 Cholestasis Cyclosporine 8.4419486331
MESH:D002779 Cholestasis pirinixic acid 8.4419176532
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003928 Diabetic Nephropathies Estradiol 9.6819279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.6819279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.1015998439 15968718 15027814 4309450 3786805 10915739 6623471 11566570 10092053 9327722 19336974 2869522 7120509 17522070 3732212 16177239 7179309 21278145 6884620 19085960 7440962 16227642
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.8719031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.9619148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.9620544844 16202921 17893378 19155303
MESH:D005234 Fatty Liver Carbon Tetrachloride 21.2216045604 16239168 15959796 17595544 12631006 61145 12795759 19224547
MESH:D005234 Fatty Liver Cyclosporine 21.2219224547
MESH:D005234 Fatty Liver pirinixic acid 21.2219236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 21.2219224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005355 Fibrosis Carbon Tetrachloride 9.8918705752
MESH:D005355 Fibrosis Cyclosporine 9.8912639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9219900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.3519176532 16221962 19772884 18467677
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9316899240
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.4515338365
MESH:D007249 Inflammation Tamoxifen 2.4819457130
MESH:D007333 Insulin Resistance Estradiol 7.7716393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.7716306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Cyclosporine 6.428314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.4215618244
MESH:D007680 Kidney Neoplasms Cyclosporine 13.7712371664
MESH:D007680 Kidney Neoplasms Estradiol 13.7715610895
MESH:D007680 Kidney Neoplasms Tamoxifen 13.7718625569
MESH:D008064 Lipidoses Tamoxifen 3.3515342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9416221502 11408273 17334410 11903743 17157831 16943688 17174718 16239168 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.1615052691 15338365 18277467 17714472 12666154 12445418 14748882 18251166 18472332 16015684 17823541 18376398 17900296 18472094 16033810 18054572 16097048 12898905 14716496 12632514 17631135 14620537 15876570 18210741 15123356 18006644 18339082 15931870 15893842 18412020 18263696 15925388 12958196 17698563 12667390 16248980 17721639 12389079 12445421 16136751 13678700 17922224 17525996 17805973 15362042 15370692 18187930 14512876 15673190 17869086 16011737 15818738 12741479 17761835 15730626 17481882 17557913 17708605 15996030 12649538 12632512 16638106 18420326 18395914 10355542 18156304 18418968 18395095 14716833 17640975 18481824 16116963 18205269 18429990 15057751 15959796 18317297 16192424 17565644 18279442 20821823 16027843 17976157 12586293 17766677 12546737 18166357 14724832 17944888 12609069 15650968 11481614 18705752
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.1614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.1615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.1618564211
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1316964402 15830285 16246199 17285989 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.9319294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.9315890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 7.9316684651
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.7715583823 12014681
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.5317203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.5316827153 11731420 19196723 14580682 19196722
MESH:D020149 Manganese Poisoning Estradiol 14.1719453300
MESH:D020149 Manganese Poisoning Tamoxifen 14.1719453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.9616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.9616411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 3.9811399458 16427766
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.1116740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1115067354
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D013088 Spermatocele Tamoxifen 4.7416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4416712894 17572228 8653321
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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