AutismKB 2.0

Annotation Detail for LDB3


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Basic Information Top
Gene Symbol:LDB3 ( CMD1C,CYPHER,FLJ35865,KIAA01613,KIAA0613,LDB3Z1,LDB3Z4,LVNC3,ORACLE,PDLIM6,ZASP )
Gene Full Name: LIM domain binding 3
Band: 10q23.2
Quick LinksEntrez ID:11155; OMIM: 605906; Uniprot ID:LDB3_HUMAN; ENSEMBL ID: ENSG00000122367; HGNC ID: 15710
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Left ventricular noncompaction 3, with or without dilated cardiomyopathy
Cardiomyopathy, dilated 1C
Myopathy, myofibrillar, ZASP-related
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C002029 17alpha-ethynylestr-5(10)-ene-3alpha,17beta-diol 17alpha-ethynylestr-5(10)-ene-3alpha,17beta-diol results in increased expression of LDB3 mRNAincreases expression 17275934
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of LDB3 mRNAincreases expression 19933214
C430898 AGN 194204 AGN 194204 results in increased expression of LDB3 mRNAincreases expression 16339527
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of LDB3 mRNAincreases expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LDB3 mRNAaffects expression 17484886
C121718 dicyclanil dicyclanil results in increased expression of LDB3 mRNAincreases expression 15664270
C006253 pirinixic acid pirinixic acid results in increased expression of LDB3 mRNAincreases expression 18445702
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LDB3 mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1811752688 15322242 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D018248 Adenoma, Liver Cell dicyclanil 19.5217162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 19.5216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 19.5216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6820435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0816011737 15721981 16192424 15700767 16050911 15673190 16097048 16227642 3786805 10355542 16124888 18705752
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.5518788625
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 3.5517162532
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4916120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated marker/mechanism
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8820889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1916354765 8697196 12621046 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.9215968718 3732212 16177239 19336974 19085960 6884620 16227642 6623471 4309450 11566570 7440962 7120509 10915739 21278145 2869522 3786805 9327722 15998439 17522070 7179309 15027814 10092053
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema pirinixic acid 7.3512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1220426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.4912631006 19224547 15959796 16045604 16239168 61145 12795759 17595544
MESH:D005234 Fatty Liver pirinixic acid 8.4920131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.6418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6420067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 9.3019176532 16221962 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3016120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.428697196 16354765 15340226 16959395 18606429
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9217157831 11408273 21278145 17174718 11903743 16943688 16239168 17334410 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5116192424 15925388 16116963 14620537 15362042 18006644 18205269 17922224 17900296 12632514 15052691 12649538 13678700 18054572 15123356 16015684 15959796 12445418 16011737 17805973 12667390 16638106 18279442 18472094 18166357 16136751 17766677 18277467 18263696 14748882 12632512 15931870 20821823 17714472 12445421 17869086 12586293 17481882 18418968 18472332 17640975 17708605 18412020 15730626 18420326 14716496 18705752 18251166 18481824 18210741 15893842 15338365 16027843 17761835 18395095 14512876 18156304 18376398 17565644 15370692 12958196 12666154 15996030 16248980 12609069 17823541 18395914 15673190 18187930 12389079 12741479 17698563 11481614 15818738 17944888 17557913 10355542 12898905 18429990 18339082 16033810 17525996 12546737 17721639 15057751 14724832 16097048 15876570 14716833 17631135 15650968 17976157 18317297
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5112878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1316246199 15830285 16964402 17285989 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9214706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.3919294768
MESH:D008113 Liver Neoplasms dicyclanil 11.3920118626
MESH:D008113 Liver Neoplasms pirinixic acid 11.3920007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.3916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.2312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2312151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
OMIM:609452 MYOPATHY, MYOFIBRILLAR, ZASP-RELATED marker/mechanism
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311222880 11399792 11896295 11118676
MESH:D011471 Prostatic Neoplasms AGN 194204 4.2516000583
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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