AutismKB 2.0

Annotation Detail for NUDT6


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Basic Information Top
Gene Symbol:NUDT6 ( ASFGF2,FGF-2,FGF-AS,FGF2AS,bFGF,gfg,gfg-1 )
Gene Full Name: nudix (nucleoside diphosphate linked moiety X)-type motif 6
Band: 4q28.1
Quick LinksEntrez ID:11162; OMIM: 606261; Uniprot ID:NUDT6_HUMAN; ENSEMBL ID: ENSG00000170917; HGNC ID: 8053
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1860Brain tumor
1993Esophagus cancer
2066Lung cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NUDT6 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NUDT6 mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in decreased expression of NUDT6 mRNAdecreases expression 20106945
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of NUDT6 mRNAaffects cotreatment|decreases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of NUDT6 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NUDT6 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NUDT6 mRNAaffects cotreatment|increases expression 17942748
C006253 pirinixic acid pirinixic acid results in increased expression of NUDT6 mRNAincreases expression 18301758
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of NUDT6 mRNAaffects cotreatment|decreases expression 17404688
D013629 Tamoxifen Tamoxifen affects the expression of NUDT6 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NUDT6 mRNAaffects cotreatment|increases expression 17942748
D014303 Trinitrotoluene Trinitrotoluene affects the expression of NUDT6 mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8114745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.3715322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 9.377525203
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Estradiol 4.3411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3414692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.7116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.3519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6017868700
MESH:D001930 Brain Injuries Progesterone 4.4715380490 15665606 15845082
MESH:D001943 Breast Neoplasms Estradiol 1.9618497071 16675129 19861407 12948864 17261762 17289903 14630087 17018787
MESH:D001943 Breast Neoplasms Progesterone 1.9617614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 1.9616202921 18855134 19189212 19288272 16873071 19066611 20135344 19059307 19084267 18425577 19189210 16273361 20544844 19244106 19410462 16818667 19115204 20859285 15668708 18984771 15565566 19289846 18351453 18997820 11161223 19200415 19011961 17242785 17893378 17049068 18815881 20390343 19155303 17440819 21138602 21152245 19221464 18629630 19487384 18821012 20065188 17261762 19103187 20005174 19142967
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7219066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7016705839
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7016924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7016924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4516120746 18670907 18850075
MESH:D002386 Cataract Trinitrotoluene 3.9615817613 14694615
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.9618566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 14.0919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.0916919318 17333356 17681005 11677210 16105132 17110522 15861022
MESH:D002779 Cholestasis pirinixic acid 14.0919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.168697196 12621046 15340226 15668235 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.7917141729 14669216
MESH:D000013 Congenital Abnormalities Trinitrotoluene 9.7915095906
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9618551238
MESH:D003490 Cyanosis Trinitrotoluene 11.9618551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5819031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Estradiol 9.3519279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.3519279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.7117187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5520420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 6.5521346803 18551238
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema pirinixic acid 7.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 16.5212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 16.5217692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 16.5219031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.7519148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.7517893378 19155303 16202921 20544844
MESH:D004715 Endometriosis Progesterone 9.4716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.4710568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Cyclosporine 20.2219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.2215345470
MESH:D005234 Fatty Liver pirinixic acid 20.2220131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 20.2214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4219069698
MESH:D005355 Fibrosis Cyclosporine 9.2112639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4110048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly pirinixic acid 15.7916221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.7915340226 16120746 12621046
MESH:D006529 Hepatomegaly Trinitrotoluene 15.7915817613
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 16354765 15340226 18606429 16959395
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6215869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.2617937319
MESH:D007248 Infertility, Male Trinitrotoluene 7.2612150543
MESH:D007249 Inflammation Progesterone 8.7815869954
MESH:D007249 Inflammation Tamoxifen 8.7819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.7812878042 12200463
MESH:D007333 Insulin Resistance Estradiol 7.5516627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.5516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 6.248314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.2415618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.9816705839
MESH:D007680 Kidney Neoplasms Cyclosporine 18.9812371664
MESH:D007680 Kidney Neoplasms Estradiol 18.9815610895
MESH:D007680 Kidney Neoplasms Tamoxifen 18.9818625569
MESH:D008064 Lipidoses Tamoxifen 3.2715342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.0614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.0618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0612878042
MESH:D008113 Liver Neoplasms pirinixic acid 7.6716377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 7.6716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2012151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.2918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2911884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0019428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.6011408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.6017203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 10.6019196722 14580682 16827153 11731420 19196723
MESH:D020149 Manganese Poisoning Estradiol 13.5519453300
MESH:D020149 Manganese Poisoning Tamoxifen 13.5519453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4215990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.6916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.6916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.4918551238
MESH:D009336 Necrosis Trinitrotoluene 11.4918551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5619410462
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2619189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 10.1411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1414600291
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.7616049721 12819281
MESH:D009784 Occupational Diseases Trinitrotoluene 9.7617852074 14694615 12819281
MESH:D010051 Ovarian Neoplasms Estradiol 5.0319401270
MESH:D010051 Ovarian Neoplasms Progesterone 5.0317393432 16525653
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311222880 11896295 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.1316740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1315067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012640 Seizures 2,4-dinitrotoluene 6.5818551238
MESH:D012640 Seizures Trinitrotoluene 6.5818551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.4616709447
MESH:D013088 Spermatocele Tamoxifen 12.4616709447
MESH:D013119 Spinal Cord Injuries Progesterone 11.6816503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 11.6819457130
MESH:D013163 Splenomegaly Trinitrotoluene 5.4215817613
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2316049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.238653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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