AutismKB 2.0

Annotation Detail for NUDT4


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Basic Information Top
Gene Symbol:NUDT4 ( DIPP2,DIPP2alpha,DIPP2beta,DKFZp686I1281,KIAA0487 )
Gene Full Name: nudix (nucleoside diphosphate linked moiety X)-type motif 4
Band: 12q22
Quick LinksEntrez ID:11163; OMIM: 609229; Uniprot ID:NUDT4_HUMAN; ENSEMBL ID: ENSG00000173598; HGNC ID: 8051
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NUDT4 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen results in decreased expression of NUDT4 mRNAdecreases expression 17942131
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NUDT4 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in increased expression of NUDT4 mRNAincreases expression 18315880
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NUDT4 mRNAdecreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NUDT4 mRNAdecreases expression 17942131
C006780 bisphenol A bisphenol A results in increased expression of NUDT4 mRNAincreases expression 12075121
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of NUDT4 mRNAdecreases expression 17942131
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of NUDT4 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of NUDT4 mRNAdecreases expression 17942131
D004041 Dietary Fats Dietary Fats results in decreased expression of NUDT4 mRNAdecreases expression 18042831
D004317 Doxorubicin NUDT4 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NUDT4 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NUDT4 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NUDT4 mRNAincreases expression 12075121
D019833 Genistein Genistein results in increased expression of NUDT4 mRNAincreases expression 12075121
D008094 Lithium Lithium results in increased expression of NUDT4 mRNAincreases expression 11331144
D017239 Paclitaxel NUDT4 protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
C041786 palm oil palm oil results in decreased expression of NUDT4 mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NUDT4 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of NUDT4 mRNAincreases expression 18445702
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NUDT4 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NUDT4 mRNAdecreases expression 16960034
D019772 Topotecan NUDT4 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014747 Vinblastine NUDT4 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7615322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.4718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 10.0020127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 10.0017418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 10.0014692618
MESH:D000230 Adenocarcinoma Genistein 10.0011473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.606695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.6216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.6216835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.1317306315
MESH:D000419 Albuminuria Doxorubicin 4.4621441931
MESH:D000544 Alzheimer Disease Lithium 3.4519621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8711748828
MESH:D000799 Angioedema Acetaminophen 3.7610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8416835338 12569548 16251483 18414634
MESH:D001161 Arteriosclerosis Dietary Fats 9.6215238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.6211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6115885639
MESH:D050197 Atherosclerosis Arsenic 3.2019371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001714 Bipolar Disorder Lithium 4.2817594078 19153942 20338123 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.4919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.4912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7115746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.6214601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.4815867366
MESH:D001862 Bone Resorption bisphenol A 3.7811985600
MESH:D001932 Brain Neoplasms Doxorubicin 3.7317150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.7220146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 3.7217123778
MESH:D001943 Breast Neoplasms Dietary Fats 3.7220435547
MESH:D001943 Breast Neoplasms Doxorubicin 3.7218382427 19526202 16826403 17369602 16595493 15136595 15994142 17983394 11325840 15939500 15668708 16096432 16935488 18628466 17426702 16264153 15993339 18695136 18234424 16115903 15692762 15567936 16322301 15634643
MESH:D001943 Breast Neoplasms Genistein 3.7216873071 17200150 16541309
MESH:D001943 Breast Neoplasms Paclitaxel 3.7216273361 11325840 16244791 16115903 15136595 18234424 18223236 18323546
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.7220435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6918705752 15673190 3786805 16097048 16192424 10355542 16227642 15721981 16124888 16050911 16011737 15700767
MESH:D002276 Carcinoid Tumor Doxorubicin 4.7316051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7316835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5415504454 17687452
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.8916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.893084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 13.8917306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.8918788625
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 13.8916023760 18059187 17876044 16234567
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.8916924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 13.8916313753
MESH:D002278 Carcinoma in Situ bisphenol A 4.9017123778
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.821485588 16201981
MESH:D002292 Carcinoma, Renal Cell Vinblastine 6.821485588
MESH:D002294 Carcinoma, Squamous Cell Arsenic 7.4518922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.4520419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.456189445
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.0018640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3218850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.4717974986 17351982 17928571 15476868 16952015 17519947 15792986 16364871 15811867 15505089 17382496 16109756 16651473 17329180 16455267 16731534 17924179 17131338 16278810 17007740 16612575 16269455 16242529 17308081 18627295
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9217334414 16243910
MESH:D002318 Cardiovascular Diseases Arsenic 7.3017938729 15738583 19152805
MESH:D002318 Cardiovascular Diseases Genistein 7.3016332659
MESH:D002340 Carotid Artery Diseases Arsenic 4.2318022660 16973168
MESH:D002386 Cataract Acetaminophen 2.5310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.376135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.3712371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0816835633
MESH:D002779 Cholestasis Cyclosporine 12.9619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.9616105132 16919318 17681005 15861022 17333356 17110522 11677210
MESH:D002779 Cholestasis pirinixic acid 12.9619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.078697196 15340226 16354765 15668235 12621046
MESH:D003110 Colonic Neoplasms Genistein 2.2717182828
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.6218802399 18259882
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.6218802399
MESH:D015179 Colorectal Neoplasms Vinblastine 3.6218802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 15322242 20055451
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9318551238
MESH:D007644 Darier Disease Lithium 5.8220338123
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.6619244398
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.2616647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2617107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.7318551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.7317562736 10663392 11834606 14550746 16109766 15619225 14725611 19739265 11461765 19923254 19085960 12540782 16781746 11529661 16227642 19420014 19164858 10915739 14986274 2444490 12705907 11287661 11421492 10774834 16485898 18713872 16081117 11743745 17522070 12153990 16393943 11739529 16177239 12392966 12958197 19416960 12594235 19370779 17906064 18071297 15968718
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.739327722 17522070 15027814 2869522 4309450 10915739 3786805 15968718 15998439 7179309 10092053 16177239 3732212 21278145 6884620 7440962 7120509 19085960 6623471 11566570 16227642 19336974
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 11.7317416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.7320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0219426721
MESH:D004362 Drug Toxicity Doxorubicin 7.8918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.8911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3918367378
MESH:D004487 Edema pirinixic acid 6.2712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.2712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1012538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.5016402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.4917359293
MESH:D016889 Endometrial Neoplasms Genistein 7.4911473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9410568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0818037988
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5716530937
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.5716481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9511564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 23.7716045604 17595544 12631006 16239168 15959796 19224547 12795759 61145
MESH:D005234 Fatty Liver Cyclosporine 23.7719224547
MESH:D005234 Fatty Liver Dietary Fats 23.7717967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 23.7715345470
MESH:D005234 Fatty Liver pirinixic acid 23.7720131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.5019069698
MESH:D005355 Fibrosis Carbon Tetrachloride 20.4218705752
MESH:D005355 Fibrosis Cyclosporine 20.4212639820 12168785
MESH:D005355 Fibrosis Dietary Fats 20.4218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.4220067830
MESH:D005534 Foot Diseases Arsenic 5.486392382
MESH:D005756 Gastritis Acetaminophen 3.5916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D005909 Glioblastoma Doxorubicin 7.1417150277
MESH:D005909 Glioblastoma Genistein 7.1416598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.4715692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.0020471113
MESH:D006330 Heart Defects, Congenital Lithium 11.0019638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.0010048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.4217875725 16495754 16244371 12587719 18674790 16330681 16707910 18006777 16144979 16244372 16879835 17888722 14766674
MESH:D006333 Heart Failure Doxorubicin 6.8717481944
MESH:D006333 Heart Failure pirinixic acid 6.8720558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8215692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5119110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 7.9716221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.9716120746 15340226 12621046
MESH:D006689 Hodgkin Disease Doxorubicin 7.5515147373 18501091 17606976
MESH:D006689 Hodgkin Disease Vinblastine 7.5518501091 18180244
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9618606429 16959395 16354765 15340226 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.6316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4516899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5121332399
MESH:D006943 Hyperglycemia pirinixic acid 3.1020558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3817050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.5321332399
MESH:D006973 Hypertension Arsenic 8.3916076760 11953799 9931084
MESH:D006973 Hypertension Cyclosporine 8.3910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.3918670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0015338365
MESH:D006987 Hypesthesia Arsenic 5.4816093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4317937319
MESH:D007249 Inflammation Dietary Fats 4.7620412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.7612878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 12.0016393666
MESH:D007333 Insulin Resistance Dietary Fats 12.0011836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 12.0016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2516580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D007642 Keratosis Arsenic 4.9012749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 9.7415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.748314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 9.7415369732 15699352 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0716707910
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.0316705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.0312371664
MESH:D007938 Leukemia Genistein 2.9817468513 18980019
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0816085563
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.4917339181
MESH:D008080 Liposarcoma Paclitaxel 4.7417353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.4711903743 17334410 16943688 16221502 17157831 17174718 16239168 11408273 21278145
MESH:D008103 Liver Cirrhosis Dietary Fats 6.4718296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.6218156304 12389079 15996030 18251166 12667390 17698563 10355542 17761835 18420326 18412020 16015684 15338365 18472332 17805973 17565644 15123356 18279442 18187930 14748882 18006644 17525996 12586293 17721639 16638106 15876570 17922224 18429990 15925388 12741479 18054572 18166357 14620537 18705752 16192424 16097048 16248980 14724832 17631135 13678700 18210741 16116963 17714472 18395095 18376398 12609069 18339082 18263696 15362042 17944888 18472094 20821823 15931870 17976157 15818738 18317297 12649538 15893842 17481882 15959796 12546737 18277467 15730626 11481614 17869086 16011737 18395914 14716833 16136751 17900296 15673190 15052691 17766677 17640975 14512876 12666154 15370692 18205269 12632512 18481824 17708605 14716496 17557913 18418968 12898905 16027843 12632514 12958196 12445418 12445421 15650968 15057751 17823541 16033810
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.6216439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.6217823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.6215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.6212878042
MESH:D008107 Liver Diseases Acetaminophen 6.4019460945 12587719 12969438 11587558 19784758 16610002 19014921 16611625
MESH:D008107 Liver Diseases Arsenic 6.4011134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.4017285989 16964402 15720792 16246199 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.1416871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.1416899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 17.557678174
MESH:D008113 Liver Neoplasms Arsenic 17.5516368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.5521137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.5519294768
MESH:D008113 Liver Neoplasms pirinixic acid 17.5515890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.5516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.672876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.6712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 13.6717085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.6712151625
MESH:D008175 Lung Neoplasms Arsenic 4.7719168569 17306315 17976673
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.7718520028 20135361 20464547 20869020 18816296 20064080 18569708 17053015 6695378
MESH:D008175 Lung Neoplasms Doxorubicin 4.7717418594 6189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7719555203 11884234
MESH:D008223 Lymphoma Doxorubicin 3.4016098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 8.7117654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 8.7114749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4815621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.0715458769
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.0714578162 12929590
MESH:D008545 Melanoma Doxorubicin 5.2616827129
MESH:D008545 Melanoma Paclitaxel 5.2616342250 12025231 12040289
MESH:D008545 Melanoma Vinblastine 5.2618176117 15577320 18332650 15577323 12374674 18505091 16248763 16809738 16432458 17761969
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4819513568
MESH:D008654 Mesothelioma Doxorubicin 3.0217638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4215792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1216381670
MESH:D052016 Mucositis Doxorubicin 4.7017415656
MESH:D009101 Multiple Myeloma Paclitaxel 3.6214749477
MESH:D009135 Muscular Diseases pirinixic acid 3.4216239165
MESH:D009203 Myocardial Infarction Doxorubicin 13.3215857846 19429709
MESH:D009203 Myocardial Infarction Genistein 13.3217141266
MESH:D009203 Myocardial Infarction Lithium 13.3216288908
MESH:D009203 Myocardial Infarction pirinixic acid 13.3219151258
MESH:D017202 Myocardial Ischemia Arsenic 8.7615371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.7612213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.1617141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.1616411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.7818551238 7678174
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.0218259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 6.0215867366
MESH:D009369 Neoplasms Benzo(a)pyrene 4.6811141357
MESH:D009369 Neoplasms pirinixic acid 4.6817405874
MESH:D009401 Nephrosis Doxorubicin 4.6816899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.0419348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.0415640375 16889571
MESH:D009421 Nervous System Malformations bisphenol A 15.9111399458 16427766
MESH:D009421 Nervous System Malformations Genistein 15.9116427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.9114600291
MESH:D009436 Neural Tube Defects Arsenic 3.4016620997
MESH:D009447 Neuroblastoma Doxorubicin 7.1415555623
MESH:D009447 Neuroblastoma Topotecan 7.1415176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8018514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.2917056641
MESH:D009503 Neutropenia Vinblastine 4.4917378895
MESH:D009765 Obesity Dietary Fats 4.3611836018 20518802 19632207 21332399 18674790 17217161 20132043 18457598 16723640
MESH:D009765 Obesity pirinixic acid 4.3620558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3516049721
MESH:D010014 Osteolysis Paclitaxel 4.8915867366
MESH:D010024 Osteoporosis Genistein 3.2019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.0016169203
MESH:D012516 Osteosarcoma Doxorubicin 4.0415930896
MESH:D010049 Ovarian Diseases bisphenol A 4.9011985600
MESH:D010051 Ovarian Neoplasms Arsenic 7.8917306315
MESH:D010051 Ovarian Neoplasms Genistein 7.8919005980
MESH:D010051 Ovarian Neoplasms Paclitaxel 7.8911161223
MESH:D010146 Pain Acetaminophen 2.3216870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.0916093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.9016905509 6392382 15371236
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0817983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0817638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1412371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.2210548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.2211222880 11896295 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.1220887781
MESH:D011471 Prostatic Neoplasms Arsenic 1.8916140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8916740699
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8916888761 16729912 16868541 18437689 15749863 15897917
MESH:D011471 Prostatic Neoplasms Genistein 1.8916925846 15378649 15256057
MESH:D011471 Prostatic Neoplasms Paclitaxel 1.8917172428 16729912 16356831 17136230
MESH:D011507 Proteinuria Arsenic 3.9221343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.2315861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2016882103
MESH:D011629 Puberty, Precocious bisphenol A 4.7010548101
MESH:D051437 Renal Insufficiency Doxorubicin 4.1317922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.3419058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012509 Sarcoma Doxorubicin 3.9117710206 16767912 15675481 18313854 17203757 15625365
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.1616326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7017846226
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2018551238
MESH:D012640 Seizures Lithium 6.2019660546
MESH:D012871 Skin Diseases Arsenic 2.7215952646 16759981 6392382 16353154 17050553 19834688 17938729 17548696 17453740 18709164 16702368
MESH:D012878 Skin Neoplasms Arsenic 13.2417029826 17050553 16251483 15504454 17976673 19538983
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.2419755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 13.2415692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.2416192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4817203757 15625365 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8616709447
MESH:D013226 Status Epilepticus Lithium 5.7119430551 19951488 19570321
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.5620155912 2093021
MESH:D013274 Stomach Neoplasms Paclitaxel 2.5618396642 18506536
MESH:D019966 Substance-Related Disorders bisphenol A 3.9016045194 16684133
MESH:D024801 Tauopathies Paclitaxel 4.7316930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.3016010429 17909728
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.6716049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 11.6717306315 19429237 11144890 15987713 19322015 18640142 17976673
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.6717053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 11.6717653716
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2310091137
MESH:D014581 Urticaria Acetaminophen 2.8910982225
MESH:D014591 Uterine Diseases bisphenol A 4.9314652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2114692618
MESH:D014605 Uveitis Cyclosporine 3.901336536
MESH:D014625 Vaginal Neoplasms Vinblastine 4.9615577323
MESH:D014652 Vascular Diseases Arsenic 4.6517056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4614671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.1317678736 16364871 17334414 17638931
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
MESH:D015430 Weight Gain Dietary Fats 3.6616723640
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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