AutismKB 2.0

Annotation Detail for NUDT5


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Basic Information Top
Gene Symbol:NUDT5 ( YSA1,YSA1H,hYSAH1 )
Gene Full Name: nudix (nucleoside diphosphate linked moiety X)-type motif 5
Band: 10p14
Quick LinksEntrez ID:11164; OMIM: 609230; Uniprot ID:NUDT5_HUMAN; ENSEMBL ID: ENSG00000165609; HGNC ID: 8052
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NUDT5 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NUDT5 mRNAaffects expression 21346803
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of NUDT5 mRNAaffects cotreatment|affects expression 17602206
C018021 cobaltous chloride cobaltous chloride results in decreased expression of NUDT5 proteindecreases expression 16622835
D004041 Dietary Fats Dietary Fats results in decreased expression of NUDT5 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of NUDT5 mRNAaffects cotreatment|affects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of NUDT5 mRNAdecreases expression 17475347
C041786 palm oil palm oil results in decreased expression of NUDT5 mRNAdecreases expression 18042831
D010634 Phenobarbital Phenobarbital affects the expression of NUDT5 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid affects the expression of NUDT5 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid results in decreased expression of NUDT5 mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in increased expression of NUDT5 mRNAincreases expression 18301758
C010327 salinomycin salinomycin results in decreased expression of NUDT5 mRNAdecreases expression 19682730
D018038 Sodium Selenite Sodium Selenite results in increased expression of NUDT5 mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.596195326
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000236 Adenoma Diethylnitrosamine 2.916695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 18.3018056438 19061943 16434500 17620307 17162532 19052882
MESH:D018248 Adenoma, Liver Cell Phenobarbital 18.3017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.3016434500
MESH:D001161 Arteriosclerosis Dietary Fats 10.3815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.3811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.0520435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0517474063
MESH:D001943 Breast Neoplasms salinomycin 2.0519682730
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7116705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7119208518 19107877 19052882 16779866 19171122 19394651 17761372 3581430 18393292 18788625 16328049 16807293 16502159 16698587 19822196 20514400 17978847 20101231 20214788 20432363 16935385 18691550 18506893 16540662 19701751 18785209 3084413 10737359 19919837 18056438 10672840 18978308 17138121 18971187 16569478 20512989 17055752 17428255 20007298 19519916 17173139 18494052 18210153 20084675 16288022 19383236 20524982 19418558 19539802 20935162 20727157 16878318 21159647 17162532 18665156 16681979 19335982 16830150 11831363
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.7117173139 6705139 20007298 20935162 1701930
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.946135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.9417174075 7505956 2727394 21159647
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.394080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7819052882
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0116105132 17333356 16919318 15861022 17681005 17110522 11677210
MESH:D002779 Cholestasis pirinixic acid 8.0119176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8915894690
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.3618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.3618551238
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 4.1615059100 16823706 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8716285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2120387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.2518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.2521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.2519107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.2515131321
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004421 Dystonia Phenobarbital 4.121851702
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.253659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.043922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.646401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.397750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.173659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2916302075
MESH:D005234 Fatty Liver Dietary Fats 19.7017967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 19.7021071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.7015345470
MESH:D005234 Fatty Liver pirinixic acid 19.7020131406 19236843
MESH:D005355 Fibrosis Dietary Fats 3.6618296743
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006529 Hepatomegaly Phenobarbital 8.9516109766
MESH:D006529 Hepatomegaly pirinixic acid 8.9519772884 16221962 19176532 18467677
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Dietary Fats 5.2920412841
MESH:D007249 Inflammation Diethylnitrosamine 5.2918785209
MESH:D007333 Insulin Resistance Dietary Fats 12.7418457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 12.7416306350
MESH:D007333 Insulin Resistance Sodium Selenite 12.7414714311
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.6716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.6716705839
MESH:D008103 Liver Cirrhosis Dietary Fats 11.3618296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.3618522880 18407596 20032147 19638242 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 11.3621047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Diethylnitrosamine 4.1917034775
MESH:D008107 Liver Diseases Phenobarbital 4.1919363144
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.667678174
MESH:D008113 Liver Neoplasms Clofibric Acid 14.6617602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.6619427195 20501860 18648771 18978307 18754104 20434301 20137499 19256749 19690152 2422723 20452335 20118626 20101389 19833225 19638242 20583210 21278145 19255062 19254457 21167192 16942905 20405173 19812893 21071580 12771043 19996281 19499222 19294768 15175105 19090486 12112319 19073162 18977376 19850985 18644402 21047994 19426721 15885732 19642983 9163691 20492335 19551842 2862719 10737359
MESH:D008113 Liver Neoplasms Phenobarbital 14.6619812893 19073162 21047994 8742319 19482888 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 14.6620007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.252876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.2517942915 18253720 16267830 18079962 9362446 18775883 19519916 18544905 19009564 19126423 18093689 18164116 21159647 17174075 19004024 18308698 3124819 17854601 2563599 19539802 18282651 16842330
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.252563599 17172636 18308698 1399818 6150874
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620970405 20512841 21163286 6695378
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1814737004
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 3.8319682730
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6317484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.8718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.877678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.609029167 3581430
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2920387270
MESH:D009765 Obesity Dietary Fats 4.5218457598 21332399 20132043 17217161 19632207 11836018 20518802 18674790 16723640
MESH:D009765 Obesity pirinixic acid 4.5220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.2312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.2316049721
MESH:D010018 Osteomalacia Phenobarbital 4.5217016548
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3816540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.3816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.422563599
MESH:D011230 Precancerous Conditions Phenobarbital 9.422563599
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3818760546
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.6712752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012640 Seizures 2,4-dinitrotoluene 10.2518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.2518551238
MESH:D012640 Seizures Phenobarbital 10.253137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.986407741
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.467505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.461399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1416049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.5110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.5110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
Pathway ID Pathway Name
KEGG:00230 Purine metabolism
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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