AutismKB 2.0

Annotation Detail for PSIP1


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Basic Information Top
Gene Symbol:PSIP1 ( DFS70,LEDGF,MGC74712,PAIP,PSIP2,p52,p75 )
Gene Full Name: PC4 and SFRS1 interacting protein 1
Band: 9p22.3
Quick LinksEntrez ID:11168; OMIM: 603620; Uniprot ID:PSIP1_HUMAN; ENSEMBL ID: ENSG00000164985; HGNC ID: 9527
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2051Leukemia
2230Alopecia
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PSIP1 mRNAaffects expression 21346803
C013813 4-anisidine 4-anisidine results in decreased expression of PSIP1 mRNAdecreases expression 12929121
D000638 Amiodarone Amiodarone results in increased expression of PSIP1 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PSIP1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PSIP1 mRNAincreases expression 20504355
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PSIP1 mRNAdecreases expression 20018196
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PSIP1 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of PSIP1 mRNAincreases expression 20106945
C014347 decitabine [decitabine co-treated with vorinostat] affects the expression of PSIP1 mRNAaffects cotreatment|affects expression 17330099
D004041 Dietary Fats Dietary Fats results in decreased expression of PSIP1 mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSIP1 mRNAaffects cotreatment|increases expression 17942748
D006918 Hydroxyurea Hydroxyurea results in decreased expression of PSIP1 mRNAdecreases expression 12929121
C041786 palm oil palm oil results in decreased expression of PSIP1 mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of PSIP1 mRNAdecreases expression 18445702
D012643 Selenium Selenium results in decreased expression of PSIP1 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSIP1 mRNAaffects cotreatment|increases expression 17942748
C111237 vorinostat [decitabine co-treated with vorinostat] affects the expression of PSIP1 mRNAaffects cotreatment|affects expression 17330099
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8415322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1620127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1614692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.646695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.8716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0619183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.7820041841 18218290 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 9.8615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.8611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6515885639
MESH:D001281 Atrial Fibrillation Amiodarone 3.8918651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 15.2119483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.2119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3417474063 20146248
MESH:D001943 Breast Neoplasms decitabine 2.3419208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 2.3420435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3420435547
MESH:D001943 Breast Neoplasms vorinostat 2.3416144943
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 1.7516705839
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6620419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.6619215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518670907 16120746 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8815710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.0818974383
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.5120889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.5112371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002779 Cholestasis Cyclosporine 13.2519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.2517681005 11677210 17110522 16919318 15861022 16105132 17333356
MESH:D002779 Cholestasis pirinixic acid 13.2519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0915668235 15340226 8697196 12621046 16354765
MESH:D003092 Colitis Selenium 3.7717936198
MESH:D003110 Colonic Neoplasms decitabine 2.3317616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0018551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D003967 Diarrhea vorinostat 4.4820479100
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.9421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Amiodarone 8.9418218290 15265979
MESH:D056486 Drug-Induced Liver Injury Selenium 8.9415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.9420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4418367378
MESH:D004487 Edema pirinixic acid 6.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9018230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1712538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.1219294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0010568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005221 Fatigue vorinostat 5.5920479100
MESH:D005234 Fatty Liver Amiodarone 24.4614986274
MESH:D005234 Fatty Liver Cyclosporine 24.4619224547
MESH:D005234 Fatty Liver Dietary Fats 24.4619551842 19004024 18296743 17967931
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.4615345470
MESH:D005234 Fatty Liver pirinixic acid 24.4619236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005355 Fibrosis Cyclosporine 14.6512168785 12639820
MESH:D005355 Fibrosis Dietary Fats 14.6518296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.6520067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.218708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.4719215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4120471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4111294989 10048152
MESH:D006333 Heart Failure pirinixic acid 6.9120558911
MESH:D006333 Heart Failure Selenium 6.9117162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006529 Hepatomegaly Amiodarone 14.3515265979
MESH:D006529 Hepatomegaly pirinixic acid 14.3516221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.3512621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.058697196 16354765 18606429 15340226 16959395
MESH:D006937 Hypercholesterolemia Amiodarone 9.109751232 8137927
MESH:D006937 Hypercholesterolemia Dietary Fats 9.1021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.6021332399
MESH:D006973 Hypertension Cyclosporine 4.9210903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9218850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 4.5017991464 18020914
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male decitabine 6.6717581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.6717937319
MESH:D007249 Inflammation Dietary Fats 4.8820412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8812878042 12200463
MESH:D007251 Influenza, Human Selenium 4.2016624496
MESH:D007333 Insulin Resistance Dietary Fats 7.2018457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.2016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4415604871
MESH:D007674 Kidney Diseases Cyclosporine 2.338314463 10903974 18776723
MESH:D007676 Kidney Failure, Chronic Selenium 3.8716518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.2116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.2112371664
MESH:D007938 Leukemia decitabine 3.0618980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 9.9819117987 17236224 18454857
MESH:D007951 Leukemia, Myeloid Hydroxyurea 9.9816532439
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 17330099
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3817679729 18206229 18460780 18704418 19010910 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4618055864
MESH:D008064 Lipidoses Amiodarone 3.4915342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8618296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1312878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.2620195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 7.2620007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.2616984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.0912151625
MESH:D008133 Long QT Syndrome Amiodarone 3.5617391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.3612587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.4818516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.1818569708 20869020 18816296 20135361 20464547 6695378 18520028 17053015 20064080
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.1819555203 11884234
MESH:D008223 Lymphoma decitabine 3.4019470736
MESH:D016410 Lymphoma, T-Cell, Cutaneous vorinostat 5.6720479100
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.7515318939
MESH:D008545 Melanoma decitabine 2.2417785578 16505122
MESH:D008654 Mesothelioma Selenium 2.7815107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7916801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1716381670
MESH:D009101 Multiple Myeloma decitabine 3.3318172295
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009181 Mycoses Amiodarone 4.9012754197 17974566
MESH:D009190 Myelodysplastic Syndromes decitabine 3.3718608210 19157545 16882708 19010910
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9316411023
MESH:D009325 Nausea vorinostat 5.5220479100
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.8518551238
MESH:D009369 Neoplasms Benzo(a)pyrene 8.1711141357
MESH:D009369 Neoplasms decitabine 8.1719470736 19116145 17925555
MESH:D009369 Neoplasms pirinixic acid 8.1717405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2718481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2014600291
MESH:D009765 Obesity Dietary Fats 4.4220518802 11836018 17217161 19632207 21332399 18674790 20132043 16723640 18457598
MESH:D009765 Obesity pirinixic acid 4.4220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.4112819281 16049721
MESH:D010051 Ovarian Neoplasms decitabine 2.6419331143 19259094
MESH:D010190 Pancreatic Neoplasms decitabine 2.7619294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010954 Plasmacytoma Selenium 4.8915087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1811896295 11399792 11118676 11222880
MESH:D055728 Primary Myelofibrosis decitabine 4.7117616702
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.6317292933
MESH:D011471 Prostatic Neoplasms vorinostat 3.6317218635
MESH:D011537 Pruritus Ethinyl Estradiol 3.3016919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2216882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8412832656 12490602 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.3819155313
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5218551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.0818724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.3410029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.348532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.3416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9416709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4520155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 2.4519037991
MESH:D013276 Stomach Ulcer Amiodarone 3.3018087811
MESH:D013610 Tachycardia Amiodarone 4.2711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.1719225199
MESH:D013921 Thrombocytopenia vorinostat 4.9520479100
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1315669648
MESH:D013959 Thyroid Diseases Amiodarone 12.0519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.0512697716
MESH:D013964 Thyroid Neoplasms decitabine 3.3117967635
MESH:D013971 Thyrotoxicosis Amiodarone 4.8519584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.1811989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.2816049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.2817053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.2817616700 19087683
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.3110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2814692618
MESH:D014604 Uveal Neoplasms decitabine 4.9117785578
MESH:D014605 Uveitis Cyclosporine 3.981336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D015430 Weight Gain Dietary Fats 3.7216723640
MESH:D014985 Xerophthalmia Cyclosporine 4.4417120751
Pathway ID Pathway Name
REACT:6185 HIV Infection
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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