AutismKB 2.0

Annotation Detail for WDHD1


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Basic Information Top
Gene Symbol:WDHD1 ( AND-1,CHTF4,CTF4 )
Gene Full Name: WD repeat and HMG-box DNA binding protein 1
Band: 14q22.2-q22.3
Quick LinksEntrez ID:11169; OMIM: 608126; Uniprot ID:WDHD1_HUMAN; ENSEMBL ID: ENSG00000198554; HGNC ID: 23170
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of WDHD1 proteinaffects expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of WDHD1 mRNAdecreases expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of WDHD1 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of WDHD1 mRNAdecreases expression 20106945
D011374 Progesterone Progesterone results in increased expression of WDHD1 mRNAincreases expression 18070364
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of WDHD1 mRNAdecreases expression 20106945
D014212 Tretinoin Tretinoin results in decreased expression of WDHD1 mRNAdecreases expression 18230668
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2411752688 15322242 14514962
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001169 Arthritis, Experimental Tretinoin 3.2316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4116456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.8912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.8916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.7817868700
MESH:D001930 Brain Injuries Progesterone 4.6215665606 15380490 15845082
MESH:D001943 Breast Neoplasms Progesterone 1.8615562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8620435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8616443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.1416011737 15721981 16124888 15700767 16192424 16227642 16050911 3786805 16097048 15673190 10355542 18705752
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.8112907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.8118788625
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.811917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3516096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5016120746 18670907 18850075
MESH:D002386 Cataract Tretinoin 3.2417460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1712371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Cyclosporine 3.1219486331
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0915668235 16354765 15340226 8697196 12621046
MESH:D002972 Cleft Palate Tretinoin 6.099407595
MESH:D003092 Colitis Tretinoin 4.0617035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5110048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.519211117 9664655 16925845 14991402 9224671 10589399 9142499 9125849 17551590 8800419
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.8517187935
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.9510915739 19336974 2869522 15998439 15027814 3786805 21278145 7120509 6623471 7179309 9327722 16227642 6884620 17522070 10092053 19085960 4309450 15968718 11566570 16177239 3732212 7440962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 13.4718230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 13.4718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.1117692515
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2816569247
MESH:D004715 Endometriosis Progesterone 9.8216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.829294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.5211564622
MESH:D005124 Eye Abnormalities Tretinoin 9.529664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.6612795759 16045604 12631006 19224547 15959796 17595544 61145 16239168
MESH:D005234 Fatty Liver Cyclosporine 8.6619224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Carbon Tetrachloride 24.3818705752
MESH:D005355 Fibrosis Cyclosporine 24.3812168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 24.3820067830
MESH:D005355 Fibrosis Tretinoin 24.3817994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D005909 Glioblastoma Tretinoin 3.1717312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.9714991402 9664655
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9219900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2516120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.498697196 15340226 16354765 18606429 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.4316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9316899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D006973 Hypertension Cyclosporine 5.2410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2418670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.4515338365
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.7615869954
MESH:D007249 Inflammation Progesterone 5.4115869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4112878042 12200463
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.8916580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.8917551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Cyclosporine 2.488314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9712371664
MESH:D007938 Leukemia Tretinoin 2.8917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1116294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3216140955 17217047 19035177 17712046 17339181 17649720 19642359 17361223 17107899 12679006 15748426 16331271 17506722 16788101 19075265 9834237 16766008 16891316 16935935 17368321 16823087 19029980 17301526 17294898 19225113
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9421278145 17157831 16943688 17334410 16221502 17174718 16239168 11903743 11408273
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5916116963 17900296 15959796 15876570 11481614 15123356 15370692 12632514 18054572 12898905 14620537 15362042 12445418 12741479 18166357 18429990 14716833 17805973 12649538 12632512 15052691 17922224 20821823 17766677 18472094 15818738 15650968 18412020 18705752 15338365 18420326 18187930 17698563 18210741 15893842 18376398 17976157 16027843 18481824 15996030 17565644 18339082 16136751 16638106 17944888 12958196 16011737 16248980 14724832 18277467 15057751 17761835 15925388 17631135 12609069 17525996 17481882 10355542 14512876 14716496 17869086 15931870 18006644 15730626 18395095 18472332 18263696 17708605 18317297 12546737 12389079 18418968 17823541 18279442 18156304 15673190 12666154 12667390 13678700 14748882 18395914 17640975 16097048 18251166 17721639 17714472 12445421 16015684 16033810 17557913 16192424 18205269 12586293
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5916248980 18397230
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1316964402 15830285 15720792 17285989 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9516899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.9315890375 9163691 18177683 2125692
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.9319294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9316984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.768603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.7612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.7612151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.3614755239
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3611884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 3.0311408345 17203775
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2217596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009369 Neoplasms Tretinoin 2.5216946489 16594593
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.6314600291
MESH:D009421 Nervous System Malformations Tretinoin 10.639125849
MESH:D009436 Neural Tube Defects Tretinoin 3.229142499
MESH:D010051 Ovarian Neoplasms Progesterone 5.1617393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 5.1616936753
MESH:D010146 Pain Tretinoin 3.1316870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5415976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911896295 11222880 11118676 11399792
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4016283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9318045962
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9416192470
MESH:D012878 Skin Neoplasms Tretinoin 5.9416467112
MESH:D013119 Spinal Cord Injuries Progesterone 4.6815862959 16503802
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2316026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9416129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.0516752155
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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