AutismKB 2.0

Annotation Detail for ADAMTS7


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Basic Information Top
Gene Symbol:ADAMTS7 ( ADAM-TS 7,ADAM-TS7,ADAMTS-7,DKFZp434H204 )
Gene Full Name: ADAM metallopeptidase with thrombospondin type 1 motif, 7
Band: 15q25.1
Quick LinksEntrez ID:11173; OMIM: 605009; Uniprot ID:ATS7_HUMAN; ENSEMBL ID: ENSG00000136378; HGNC ID: 223
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ADAMTS7 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ADAMTS7 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ADAMTS7 mRNAincreases expression 16788091
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of ADAMTS7 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ADAMTS7 mRNAaffects expression 17562736
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ADAMTS7 mRNAaffects expression 17351261
D019833 Genistein Genistein results in increased expression of ADAMTS7 mRNAincreases expression 18847459
C002950 methylformamide methylformamide affects the expression of ADAMTS7 mRNAaffects expression 17040096
C002950 methylformamide methylformamide analog affects the expression of ADAMTS7 mRNAaffects expression 17040096
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.287525203
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.5314692618
MESH:D000230 Adenocarcinoma Genistein 4.5311473722
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Genistein 2.5017200150 16873071 16541309
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.833084413
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.8316924424
MESH:D002318 Cardiovascular Diseases Genistein 3.4616332659
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.8514694615
MESH:D002386 Cataract Acetaminophen 7.8510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.936135515
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0516919318 17681005 11677210 17333356 16105132 17110522 15861022
MESH:D003110 Colonic Neoplasms Genistein 2.3217182828
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.3715095906
MESH:D003324 Coronary Artery Disease marker/mechanism 21378990
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9418551238
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5316647724
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.5121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.5121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 9.5121346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.5119739265 19416960 12540782 17522070 18713872 11421492 17906064 14725611 11287661 16781746 14550746 15968718 11743745 12705907 10915739 12958197 12153990 18071297 10663392 11461765 11529661 16393943 2444490 16227642 11739529 19164858 15619225 19420014 19923254 11834606 17562736 19370779 12392966 16177239 16485898 16109766 12594235 19085960 14986274 16081117 10774834
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.9316402032
MESH:D016889 Endometrial Neoplasms Genistein 3.5111473722
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.0515345470
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005909 Glioblastoma Genistein 3.4016598420
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007674 Kidney Diseases Acetaminophen 2.3215629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.0416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.0416705839
MESH:D007938 Leukemia Genistein 3.1318980019 17468513
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.0617823541
MESH:D008107 Liver Diseases Acetaminophen 1.6719460945 16611625 19014921 19784758 12969438 11587558 12587719 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.227678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.682876786 6135515 2876784
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0814578162 12929590
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009203 Myocardial Infarction Genistein 2.9417141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.8417141266
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.507678174 18551238
MESH:D009421 Nervous System Malformations Genistein 4.3116427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.5316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.5316049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 16.5314694615
MESH:D010024 Osteoporosis Genistein 3.3919401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3516169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6619005980
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D011471 Prostatic Neoplasms Genistein 3.4215378649 15256057 16925846
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3918551238
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7815869587 14671159
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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