AutismKB 2.0

Annotation Detail for LZTS1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:LZTS1 ( F37,FEZ1 )
Gene Full Name: leucine zipper, putative tumor suppressor 1
Band: 8p21.3
Quick LinksEntrez ID:11178; OMIM: 606551; Uniprot ID:LZTS1_HUMAN; ENSEMBL ID: ENSG00000061337; HGNC ID: 13861
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1976Squamous cell cancer
2200Intraocular melanoma
2237Neoplasm metastasis
Desease Name
prostate cancer
CANCER
PSYCH
major depressive disorder (broad)
No data
Desease Name
Esophageal squamous cell carcinoma
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of LZTS1 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LZTS1 mRNAaffects expression 16483693
D002117 Calcitriol Calcitriol results in increased expression of LZTS1 mRNAincreases expression 16002434
D005419 Flavonoids Flavonoids results in increased expression of LZTS1 mRNAincreases expression 18035473
C065180 fluvastatin [zoledronic acid co-treated with fluvastatin] results in increased expression of LZTS1 mRNAaffects cotreatment|increases expression 16996129
D015739 Nocodazole LZTS1 protein affects the susceptibility to Nocodazoleaffects response to substance 17349584
C088658 zoledronic acid [zoledronic acid co-treated with fluvastatin] results in increased expression of LZTS1 mRNAaffects cotreatment|increases expression 16996129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D058186 Acute Kidney Injury zoledronic acid 4.7419715164
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.8820200999
MESH:D001859 Bone Neoplasms zoledronic acid 5.2619442620 16778634 11697798 15867366 16121404 17312309
MESH:D001862 Bone Resorption zoledronic acid 4.9818496637 11869084 8053405 15845617 16769263 18404659
MESH:D001943 Breast Neoplasms Calcitriol 2.6711237771
MESH:D001943 Breast Neoplasms zoledronic acid 2.6716096432 18695136
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 1.7816705839
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 3.6219233551
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 3.9618507039
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6811237771
MESH:D003327 Coronary Disease fluvastatin 4.9716142594
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3718551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 2.0318551238 21346803
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.2615138306
MESH:D004938 Esophageal Neoplasms marker/mechanism
MESH:D005264 Femoral Fractures zoledronic acid 6.2216234978
MESH:D006930 Hyperalgesia zoledronic acid 4.4716769263
MESH:D006934 Hypercalcemia zoledronic acid 5.3319622757 18089816
MESH:D006996 Hypocalcemia zoledronic acid 6.6412669777
MESH:D007249 Inflammation Flavonoids 2.7717296493
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2116705839
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 5.0518089816
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 3.8817312309
MESH:D008654 Mesothelioma zoledronic acid 3.8416675582
MESH:D009101 Multiple Myeloma fluvastatin 8.8116996129
MESH:D009101 Multiple Myeloma zoledronic acid 8.8118089719 16996129 19621390
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2518551238
MESH:D009362 Neoplasm Metastasis zoledronic acid 3.7315867366 17312309 19139120
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6916049721 12819281
MESH:D010014 Osteolysis zoledronic acid 5.7715867366
MESH:D010024 Osteoporosis zoledronic acid 4.1917882678
MESH:D010146 Pain zoledronic acid 4.1716475674
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.1815572423
MESH:D011471 Prostatic Neoplasms marker/mechanism 12377406
MESH:D011471 Prostatic Neoplasms Calcitriol 3.6818247401 16644109 12479363 16289102 15754350
MESH:D011471 Prostatic Neoplasms zoledronic acid 3.6819103299 12438248
MESH:D012512 Sarcoma, Ewing's zoledronic acid 5.2616121404
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7118551238
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3716049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7110091137
Pathway ID Pathway Name
REACT:1788 Transcription
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved