AutismKB 2.0

Annotation Detail for MAP4K5


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Basic Information Top
Gene Symbol:MAP4K5 ( GCKR,KHS,KHS1,MAPKKKK5 )
Gene Full Name: mitogen-activated protein kinase kinase kinase kinase 5
Band: 14q22.1
Quick LinksEntrez ID:11183; OMIM: 604923; Uniprot ID:M4K5_HUMAN; ENSEMBL ID: ENSG00000012983; HGNC ID: 6867
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00006Apoptosis signaling pathway
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Related Diseases/Disorders Top
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Desease IDDesease Name
1904Diabetes mellitus
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of MAP4K5 mRNAdecreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of MAP4K5 mRNAaffects expression 17562736
D001104 Arbutin Arbutin results in decreased expression of MAP4K5 mRNAdecreases expression 17103032
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of MAP4K5 mRNAaffects expression 17331233
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MAP4K5 mRNAdecreases expression 20018196
D016572 Cyclosporine Cyclosporine results in increased expression of MAP4K5 mRNAincreases expression 20106945
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of MAP4K5 mRNA]affects reaction|decreases expression 15016801
D012643 Selenium [Selenium deficiency co-treated with Vitamin E deficiency] results in increased expression of MAP4K5 mRNAaffects cotreatment|increases expression 11444866
D018038 Sodium Selenite Sodium Selenite results in decreased expression of MAP4K5 mRNAdecreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MAP4K5 mRNAincreases expression 17555868
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MAP4K5 mRNAdecreases expression 19933214
D014810 Vitamin E [Selenium deficiency co-treated with Vitamin E deficiency] results in increased expression of MAP4K5 mRNAaffects cotreatment|increases expression 11444866
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 14514962 11752688
MESH:D000230 Adenocarcinoma Fluorouracil 2.4517638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000740 Anemia Fluorouracil 9.1217963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.1211748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Fluorouracil 2.0415136595 16557594 19217205 18357371 16595493 18608205 16110121
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0420435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8916051944
MESH:D002277 Carcinoma Fluorouracil 8.5617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.5616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.003084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.0016332177 17971768 17045692 17088986 18930000 16799960
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0718695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5218986760 16280240 17066447 16757204
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8712371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Cyclosporine 3.0219486331
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1516354765 15340226 12621046 8697196 15668235
MESH:D003092 Colitis Selenium 3.9517936198
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2517169374 15001691 17172411 17725105 16340194 16510598 18772588 17016597 17018589 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018949393 18448328 17094418 17695437 15289873 16303861 18288408 18802399 16391804 17454858 17594712 16282729 17016601 18383874 17255274 20501625 14970324 16331619 17401013 15148649 16524972 18509181
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5219769572
MESH:D007644 Darier Disease Fluorouracil 4.9916733453
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2819085960 19923254 16081117 11743745 14725611 12153990 16781746 16485898 17522070 18713872 11421492 12540782 16109766 11529661 12958197 14550746 16177239 10663392 12392966 19164858 19416960 11739529 14986274 10915739 12705907 12594235 11461765 19420014 19739265 11287661 11834606 19370779 16227642 2444490 16393943 17562736 15968718 10774834 18071297 17906064 15619225
MESH:D056486 Drug-Induced Liver Injury Selenium 9.2815131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.2815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6220426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6216785472 16337965 16481741 15173087 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Cyclosporine 2.9919224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Cyclosporine 9.0712639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0720067830
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D005910 Glioma Fluorouracil 2.9216145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4815102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8011294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.8016080930
MESH:D006333 Heart Failure Selenium 3.1517162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2615340226 8697196 16959395 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212200463 12878042
MESH:D007251 Influenza, Human Selenium 11.7016624496
MESH:D007251 Influenza, Human Vitamin E 11.7016624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.3614714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 10.4515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.4518776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 10.4512488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007680 Kidney Neoplasms Cyclosporine 7.7912371664
MESH:D007680 Kidney Neoplasms Fluorouracil 7.7916985049
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3812878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.3816169303
MESH:D008107 Liver Diseases Acetaminophen 1.6619014921 11587558 19460945 12587719 12969438 16611625 16610002 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms Fluorouracil 4.6517045692 18383874 16603448 15113037
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1912151625
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.2017365036
MESH:D008175 Lung Neoplasms Fluorouracil 3.5015246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5019555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 3.5011062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9915086387
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8515318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.5016166281 16966607 18303189
MESH:D008654 Mesothelioma Selenium 6.5015107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7418986760 16757204
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009369 Neoplasms Fluorouracil 2.6718239605 18600527 16928823
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5316436463
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7116500647 16929163 19003803 15113037
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.0710923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811118676 11399792 11896295 11222880
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.6019082440 18626508
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6018760546
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6015084515
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0717322281 17975199 17365031 15814490
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1415538739 18286688 18722050 16160472
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0019015929 18567086 17522103 17498489 16424979 15786421 16951190 17172411 18396642 19084572
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1216280240
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0116803524
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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