AutismKB 2.0

Annotation Detail for MAP4K1


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Basic Information Top
Gene Symbol:MAP4K1 ( HPK1 )
Gene Full Name: mitogen-activated protein kinase kinase kinase kinase 1
Band: 19q13.1-q13.4
Quick LinksEntrez ID:11184; OMIM: 601983; Uniprot ID:M4K1_HUMAN; ENSEMBL ID: ENSG00000104814; HGNC ID: 6863
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
No data
Pathway IDPathway Name
200005BCR signaling pathway
200129JNK signaling in the CD4+ TCR pathway
200156Signaling events mediated by Stem cell factor receptor (c-Kit)
200022TCR signaling in naive CD4+ T cells
Pathway IDPathway Name
P00006Apoptosis signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C068073 Am 580 Am 580 results in decreased expression of MAP4K1 mRNAdecreases expression 16982809
C061133 Am 80 Am 80 results in increased expression of MAP4K1 mRNAincreases expression 17229644
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of MAP4K1 mRNAaffects expression 17331233
D002101 Cacodylic Acid Cacodylic Acid results in decreased expression of MAP4K1 mRNAdecreases expression 17720352
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of MAP4K1 mRNAdecreases expression 14648872
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MAP4K1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAP4K1 mRNAaffects cotreatment|increases expression 17942748
C029424 hydrazine hydrazine results in decreased expression of MAP4K1 mRNAdecreases expression 15282401
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MAP4K1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of MAP4K1 mRNAincreases expression 20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of MAP4K1 mRNA]increases expression|increases reaction 20059764
D011794 Quercetin Quercetin results in decreased expression of MAP4K1 mRNAdecreases expression 15309432
C089730 rosiglitazone rosiglitazone results in decreased expression of MAP4K1 mRNAdecreases expression 16982809
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAP4K1 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.5616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5616835633
MESH:D000544 Alzheimer Disease rosiglitazone 2.8819621015
MESH:D000686 Amyloidosis Diethylstilbestrol 4.6415469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.3817084956
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001172 Arthritis, Rheumatoid Am 80 3.7816819260
MESH:D001260 Ataxia Telangiectasia Quercetin 5.1715336622
MESH:D050197 Atherosclerosis Am 80 4.4116484594
MESH:D001327 Autoimmune Diseases Quercetin 4.5819761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Cacodylic Acid 2.0617474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0617129689 15324884
MESH:D001943 Breast Neoplasms Quercetin 2.0618628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0620435547
MESH:D002105 Cadmium Poisoning Quercetin 5.7616962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 3.3816924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Quercetin 3.3812508355 19519916
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.1317234771
MESH:D006332 Cardiomegaly Quercetin 7.0419794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.0416120746 18850075 18670907
MESH:D002386 Cataract Am 580 4.4217460283
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0915861022 16919318 17333356 17681005 11677210 16105132 17110522
MESH:D002779 Cholestasis pirinixic acid 8.0919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.158697196 15340226 16354765 15668235 12621046
MESH:D003092 Colitis Am 580 5.1317035595
MESH:D003110 Colonic Neoplasms Quercetin 2.4419440933 11134977 17148506 17191121 16640504 15741050 19056647
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.7216002989 12952375
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.4217446233
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8519496084
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.6012642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6017107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema pirinixic acid 12.3012083418
MESH:D004487 Edema rosiglitazone 12.3012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.3012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Am 80 10.0616819260
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0612538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.8916402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.5516804899 15700306
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.9815345470
MESH:D005234 Fatty Liver pirinixic acid 13.9820131406 19236843
MESH:D005234 Fatty Liver rosiglitazone 13.9819196556
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7316513791 15751030 16611131 16002989 16534752
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Quercetin 9.3519474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3520067830
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.1416452187
MESH:D005909 Glioblastoma Quercetin 3.4819804834
MESH:D005910 Glioma Quercetin 3.1017643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4011294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly pirinixic acid 8.8516221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.8515340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2615340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia rosiglitazone 4.0312083418
MESH:D006943 Hyperglycemia pirinixic acid 9.6820558911
MESH:D006943 Hyperglycemia Quercetin 9.6818262572 11834736
MESH:D006965 Hyperplasia Diethylstilbestrol 4.6112960047 14722030
MESH:D006973 Hypertension Quercetin 5.3818356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3818850075 18670907
MESH:D007021 Hypospadias Diethylstilbestrol 11.8416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 11.8416945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.5215036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation rosiglitazone 5.4012083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4012878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.7216624496
MESH:D007333 Insulin Resistance pirinixic acid 7.8016306350
MESH:D007333 Insulin Resistance rosiglitazone 7.8016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007627 Keloid Quercetin 5.1317086741
MESH:D007674 Kidney Diseases Quercetin 3.1716962696
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 3.5816762066 15003126 14681315
MESH:D007859 Learning Disorders Diethylstilbestrol 4.2417184923
MESH:D007938 Leukemia Quercetin 3.2217468513
MESH:D015473 Leukemia, Promyelocytic, Acute Am 80 4.7316531727 16819260
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.1015474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 5.1012741479
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 5.1017347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.1012878042
MESH:D008113 Liver Neoplasms Diethylstilbestrol 11.1115890375 16712894
MESH:D008113 Liver Neoplasms pirinixic acid 11.1115890375 20007298 16377806
MESH:D008113 Liver Neoplasms Quercetin 11.1118980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1116984957
MESH:D008114 Liver Neoplasms, Experimental Quercetin 6.2019519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2012151625
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.2017365036
MESH:D008175 Lung Neoplasms Quercetin 2.4516280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4511884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.3415166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5715700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.7316002989
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 3.4816827153
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2318303189 16966607 16166281
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.4917261469
MESH:D009101 Multiple Myeloma Am 80 4.6317229644
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 5.9019151258
MESH:D009203 Myocardial Infarction Quercetin 5.9019595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.8016411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.8019207477
MESH:D009369 Neoplasms Diethylstilbestrol 8.7015313581
MESH:D009369 Neoplasms pirinixic acid 8.7017405874
MESH:D009369 Neoplasms Quercetin 8.7015185748
MESH:D009421 Nervous System Malformations Diethylstilbestrol 10.1911399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1914600291
MESH:D020078 Neurogenic Inflammation Quercetin 4.5117929310
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.3719495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.7719005980
MESH:D010190 Pancreatic Neoplasms Quercetin 2.8916965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.3914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.8515687265 16977796
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.0710923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Quercetin 4.1019056647
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 10.2217184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.2211222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Am 80 2.8416289102
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.8417136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Quercetin 2.8414715546 17292933
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D011565 Psoriasis Am 80 4.1316819260
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0715814490 17322281 17365031 17975199
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012554 Schistosomiasis japonica Quercetin 5.7616862918
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013088 Spermatocele Diethylstilbestrol 12.4516709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 12.4516709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D001749 Urinary Bladder Neoplasms Cacodylic Acid 8.9015537745
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.9016712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.9016720314
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.1616175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.3914652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 10.0215809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.0214692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.6116002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30609
    • No data
    No data
    Releated drug ID Related drug Name
    PA10804imatinib
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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