AutismKB 2.0

Annotation Detail for PKP3


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Basic Information Top
Gene Symbol:PKP3 ( - )
Gene Full Name: plakophilin 3
Band: 11p15.5
Quick LinksEntrez ID:11187; OMIM: 605561; Uniprot ID:PKP3_HUMAN; ENSEMBL ID: ENSG00000184363; HGNC ID: 9025
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PKP3 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of PKP3 mRNAaffects expression 18648102
C015001 arsenite arsenite results in increased expression of PKP3 mRNAincreases expression 18191166
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PKP3 mRNAincreases expression 17035482
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4714514962 15322242 11752688
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.963712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.0116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.7411289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.1016705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.107296757 3581430
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.837296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5616120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.027505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.4419486331 9022650
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2415668235 15340226 8697196 12621046 16354765
MESH:D003110 Colonic Neoplasms arsenite 2.6315037631
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2720055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5818551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.352524372 18759878 8970840 8156756 11298694 12868966 11906362 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.953621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.7218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.729653073 18692083 9022650 16192314 7440962 6679447 8291058 1440618 6482804 18289764 18648102 11289319 9328219
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.7220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6216714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.4210568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.183581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005234 Fatty Liver arsenite 4.2018296743
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.746705139
MESH:D005355 Fibrosis arsenite 10.7618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.7620067830
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.507505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5111294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.026705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.4515340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.7716959395 18606429 8697196 16354765 15340226
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5015034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0218670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0312200463 12878042
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.748074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.5216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.526582329
MESH:D008103 Liver Cirrhosis arsenite 3.6118296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4215034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8316984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.501399818 3712494 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.5012151625
MESH:D008175 Lung Neoplasms arsenite 2.5616809336
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5619555203 11884234
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4918551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.593581430
MESH:D009389 Neovascularization, Pathologic arsenite 5.0415738583
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.7214600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.156679447
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 10.2212819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 10.226482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.743988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.047296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.196228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.8211118676 11222880 11399792 11896295
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.673692021
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7918551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2016192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.196582329 3712494 1399818 6587162 7505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.4316049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.438074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.9510091137
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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