AutismKB 2.0

Annotation Detail for WBP4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:WBP4 ( FBP21,MGC117310 )
Gene Full Name: WW domain binding protein 4 (formin binding protein 21)
Band: 13q14.11
Quick LinksEntrez ID:11193; OMIM: 604981; Uniprot ID:WBP4_HUMAN; ENSEMBL ID: ENSG00000120688; HGNC ID: 12739
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of WBP4 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of WBP4 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of WBP4 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of WBP4 mRNAaffects expression 16483693
D005472 Fluorouracil Fluorouracil affects the expression of WBP4 mRNAaffects expression 16584549
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of WBP4 mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of WBP4 mRNAaffects cotreatment|increases expression 17183730
C025643 vinclozolin vinclozolin affects the expression of WBP4 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.828875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000230 Adenocarcinoma Fluorouracil 2.4717638652
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D000740 Anemia Fluorouracil 3.9415504547 17963324 16511603
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001008 Anxiety Disorders Valproic Acid 9.5017497229
MESH:D001008 Anxiety Disorders vinclozolin 9.5019015723
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8617688650 18316065 17157402 19232924 20603192 18940202 18775368 18558336 18396377 19460635 18985861 17507914 18177632 16609825 15238991
MESH:D001714 Bipolar Disorder Valproic Acid 3.1820046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.548888407
MESH:D001943 Breast Neoplasms Fluorouracil 2.4515136595 18608205 19217205 16595493 18357371 16557594 16110121
MESH:D002276 Carcinoid Tumor Fluorouracil 5.0416051944
MESH:D002277 Carcinoma Fluorouracil 3.7617121937
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8216705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.823084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.8217088986 17045692 17971768 16332177 16799960 18930000
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1118695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5516280240 18986760 16757204 17066447
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.936135515
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2618772588 15001691 17725105 16510598 17287894 17169374 17016597 17018589 17172411 16340194
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018383874 16391804 16303861 17695437 18509181 20501625 15148649 17401013 16331619 16524972 15289873 17094418 17454858 18448328 17255274 17594712 18288408 16282729 18949393 14970324 17016601 18802399
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 8888407 16575769
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9418551238
MESH:D007644 Darier Disease Fluorouracil 5.1316733453
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.4821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.4821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.4816109766 10915739 16177239 14986274 12392966 11461765 16485898 17906064 15619225 12540782 16081117 11287661 16393943 11739529 2444490 18071297 19164858 15968718 12958197 12153990 12594235 11421492 17562736 16227642 19923254 11743745 10774834 11529661 19085960 17522070 19370779 11834606 19739265 16781746 10663392 18713872 14725611 14550746 19416960 12705907 19420014
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.4819641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.4617275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.2916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0420417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.807562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5015173087 16337965 16481741 16785472 17638652
MESH:D005234 Fatty Liver Valproic Acid 3.5419224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.4118558336 8888407
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D005910 Glioma Fluorouracil 2.9516145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5415162350 18337622 15102660
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.9316612254
MESH:D007248 Infertility, Male vinclozolin 3.1916467254
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.6516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.6516705839
MESH:D007680 Kidney Neoplasms Fluorouracil 13.6516985049
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1816294345 17596541
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008107 Liver Diseases Acetaminophen 1.6716611625 12587719 19014921 11587558 19460945 19784758 12969438 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.917678174
MESH:D008113 Liver Neoplasms Fluorouracil 4.9115113037 18383874 17045692 16603448
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.686135515 2876786 2876784
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D008175 Lung Neoplasms Fluorouracil 2.0115246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.1315086387
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008881 Migraine Disorders Valproic Acid 3.3618765137 18803445
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8116757204 18986760
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2817596541
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.5018551238 7678174
MESH:D009369 Neoplasms Fluorouracil 2.7118239605 18600527 16928823
MESH:D009436 Neural Tube Defects Valproic Acid 3.2716359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5916436463
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.6612819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.6616049721
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7316929163 15113037 19003803 16500647
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.8720603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.8719015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3718626508 19082440
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D019310 Pseudolymphoma Valproic Acid 4.9211422049 12752131
MESH:D012004 Rectal Neoplasms Fluorouracil 4.2318286688 18722050 16160472 15538739
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4419155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 10.7518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.7518551238
MESH:D012640 Seizures Valproic Acid 10.7514763951 11044598 16876388 15475178 3137016 1511512 17978042 11738929
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0016424979 17172411 17522103 18396642 19084572 15786421 18567086 16951190 17498489 19015929
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2216280240
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2816049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1116803524
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved