AutismKB 2.0

Annotation Detail for ADCY6


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Basic Information Top
Gene Symbol:ADCY6 ( AC6,DKFZp779F075,KIAA0422 )
Gene Full Name: adenylate cyclase 6
Band: 12q13.12
Quick LinksEntrez ID:112; OMIM: 600294; Uniprot ID:ADCY6_HUMAN; ENSEMBL ID: ENSG00000174233; HGNC ID: 237
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04270Vascular smooth muscle contraction
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa05414Dilated cardiomyopathy
hsa04540Gap junction
hsa04962Vasopressin-regulated water reabsorption
hsa04970Salivary secretion
hsa04972Pancreatic secretion
hsa00230Purine metabolism
hsa04971Gastric acid secretion
hsa04114Oocyte meiosis
hsa04742Taste transduction
hsa04062Chemokine signaling pathway
Pathway IDPathway Name
Signaling by GPCR
Diabetes pathways
Signalling by NGF
Transmembrane transport of small molecules
Opioid Signalling
Integration of energy metabolism
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00019Endothelin signaling pathway
P05731GABA-B receptor II signaling
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1943Adenocarcinoma
2075Heart failure
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ADCY6 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADCY6 mRNAaffects expression 16483693
C095105 bexarotene bexarotene results in decreased expression of ADCY6 mRNAdecreases expression 16648578
D002220 Carbamazepine Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY6 protein]affects binding|decreases reaction|increases activity 19922557
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of ADCY6 mRNAdecreases expression 15171707
D004280 Dobutamine ADCY6 protein affects the susceptibility to Dobutamineaffects response to substance 12393090
D004958 Estradiol Estradiol affects the expression of ADCY6 mRNAaffects expression 15598610
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ADCY6 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ADCY6 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADCY6 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in increased expression of ADCY6 mRNAincreases expression 18035473
D005576 Forskolin ADCY6 protein affects the susceptibility to Forskolinaffects response to substance 12393090
D007213 Indomethacin Indomethacin results in decreased expression of ADCY6 proteindecreases expression 15579502
D007545 Isoproterenol ADCY6 protein affects the susceptibility to Isoproterenolaffects response to substance 12393090
D009151 Mustard Gas Mustard Gas results in decreased expression of ADCY6 mRNAdecreases expression 15674843
D010081 Oxazolone Oxazolone results in decreased expression of ADCY6 mRNAdecreases expression 11379042
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of ADCY6 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of ADCY6 mRNAincreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ADCY6 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of ADCY6 mRNAincreases expression 18301758
D012643 Selenium Selenium results in increased expression of ADCY6 mRNAincreases expression 19244175
C071262 SK&F 82958 Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY6 protein]affects binding|decreases reaction|increases activity 19922557
C071262 SK&F 82958 [SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY6 proteinaffects binding|increases activity 19922557
D013629 Tamoxifen Tamoxifen affects the expression of ADCY6 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADCY6 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ADCY6 mRNAdecreases expression 18796159
D014051 Toluene 2,4-Diisocyanate Toluene 2,4-Diisocyanate results in increased expression of ADCY6 mRNAincreases expression 11379042
D014810 Vitamin E Vitamin E results in increased expression of ADCY6 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4214745880
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 13.588986270
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 13.586195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.5814514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.4318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8117505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9918653653
MESH:D000230 Adenocarcinoma Estradiol 6.9111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.9114692618
MESH:D000230 Adenocarcinoma Indomethacin 6.9116537180
MESH:D000236 Adenoma Indomethacin 3.3811497255
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.5317620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.5316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.5316835633
MESH:D016301 Alveolar Bone Loss Indomethacin 5.2417225004
MESH:D000544 Alzheimer Disease Indomethacin 2.6817627676 15579461
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3515469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8311748828
MESH:D001014 Aortic Aneurysm Indomethacin 4.7210231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.7410388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3311256880
MESH:D018771 Arthralgia Indomethacin 5.042160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5815885639
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.7911248219
MESH:D001249 Asthma Mustard Gas 5.2710378619
MESH:D001249 Asthma Toluene 2,4-Diisocyanate 5.2720032816 11742282 11467998 8156442 15590890 12762349 16792590 12585506 15855793 6091946 11077013 16210060 6091945 19187332 10934080 10797510 18394133 12684321 17015710 3040596 170078 15590891 7684630
MESH:D001477 Bartter Syndrome Indomethacin 4.8510684365
MESH:D001714 Bipolar Disorder Carbamazepine 4.0717594078 20046352
MESH:D001768 Blister Mustard Gas 5.0319167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.3719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6815746008
MESH:D001919 Bradycardia Isoproterenol 5.056740701
MESH:D001929 Brain Edema Indomethacin 4.9011481608
MESH:D002545 Brain Ischemia Indomethacin 4.2912524144
MESH:D001943 Breast Neoplasms bexarotene 3.6916818667 16344269
MESH:D001943 Breast Neoplasms Diethylstilbestrol 3.6915324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 3.6916675129 12948864 14630087 17261762 18497071 17018787 17289903 19861407
MESH:D001943 Breast Neoplasms Indomethacin 3.6917401462
MESH:D001943 Breast Neoplasms Tamoxifen 3.6919244106 17261762 17440819 20859285 19066611 19084267 19487384 19200415 17049068 19221464 19103187 19115204 20065188 15668708 18997820 17893378 18821012 20390343 16273361 21152245 21138602 18815881 19410462 20544844 19059307 19011961 16873071 19189210 16818667 15565566 18984771 19288272 18629630 19189212 20135344 19155303 18351453 18425577 17242785 11161223 19289846 19142967 18855134 16202921 20005174
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6920435547
MESH:D001943 Breast Neoplasms Toluene 2,4-Diisocyanate 3.6911921183
MESH:D016535 Bronchial Hyperreactivity Toluene 2,4-Diisocyanate 4.4312507178 8156442 15590891
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.0315286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.8510378619 17687719
MESH:D002056 Burns Indomethacin 4.5710459503
MESH:D002100 Cachexia Indomethacin 4.8716537180 15141370 11239499 15625704
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3316111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8016050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3819066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.1216705839
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 11.1216924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.1216924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 11.1216391822
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 11.121701930 20007298 17173139 20935162 6705139
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 11.1216924424
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.5911053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.2214736730 18791128 11352223
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.1816247446
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.3117341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 2.8112636206 15482327
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5017572228
MESH:D006332 Cardiomegaly Isoproterenol 6.887544033 11179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.8818670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.6818566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.124080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D002764 Cholecystitis Indomethacin 5.0411181007
MESH:D002779 Cholestasis Ethinyl Estradiol 7.4215861022 16105132 17110522 16919318 17333356 11677210 17681005
MESH:D002779 Cholestasis pirinixic acid 7.4219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.058697196 12621046 15668235 15340226 16354765
MESH:D003092 Colitis Selenium 3.6517936198
MESH:D003110 Colonic Neoplasms Indomethacin 2.5715936596 15963497 15786552 11260862 15625704 15637740
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3518059344 12606626 11197048 17054584
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9514669216 17141729
MESH:D018352 Coronavirus Infections Indomethacin 5.5917302372
MESH:D019465 Craniofacial Abnormalities Carbamazepine 3.849014606
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8410048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8419769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.4312952375 16002989
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.8818551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2319031437
MESH:D017449 Dermatitis, Allergic Contact Toluene 2,4-Diisocyanate 3.9812956900 15491423 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3718249437
MESH:D003877 Dermatitis, Contact Oxazolone 9.7715944321 12811023
MESH:D003877 Dermatitis, Contact Toluene 2,4-Diisocyanate 9.7717010967
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6417107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.4719279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.4719279558
MESH:D003967 Diarrhea Indomethacin 3.677907874 7237001
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.3111748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.3316538175 16538176 15057820 20216337
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.7118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 8.7117465707
MESH:D056486 Drug-Induced Liver Injury Selenium 8.7115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.7120420201
MESH:D004362 Drug Toxicity Carbamazepine 8.0820216337
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.0811462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.0218043480 16133044 18446180 12774134 17190690 16326151
MESH:D004381 Duodenal Ulcer Indomethacin 4.0111595415 11595431 10671773 17202747 16699067 17045617 17151854 17329845 17351913 11535926 11991626
MESH:D004421 Dystonia Phenobarbital 3.881851702
MESH:C538011 Eales disease Vitamin E 4.579068938
MESH:D004487 Edema Indomethacin 15.478985016 7907874 10653021 19703484 8273558 16100529 7990266
MESH:D004487 Edema Mustard Gas 15.4711402378 9260866 11428647 11428631
MESH:D004487 Edema pirinixic acid 15.4712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 15.4712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7716714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 14.7117654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.7112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.7119031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.5616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 11.9815700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 11.9811473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.9816202921 20544844 17893378 19155303
MESH:D004715 Endometriosis Indomethacin 8.6815652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.689294722 10568697
MESH:D019446 Endotoxemia Indomethacin 4.3718509659
MESH:D004751 Enteritis Indomethacin 4.6217763956 10567023 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.8517980183
MESH:D004802 Eosinophilia Indomethacin 8.9611298111
MESH:D004802 Eosinophilia Toluene 2,4-Diisocyanate 8.968156442
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.1318855540 20485159 19915237 16415921 16538176
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 10.7517275665
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 10.753659116
MESH:D004828 Epilepsies, Partial Carbamazepine 9.9317116037 16628512 15008574
MESH:D004828 Epilepsies, Partial Phenobarbital 9.9311558140 3922381
MESH:D004827 Epilepsy Carbamazepine 6.8317465707 19439326 18234410 17178248 821787 20417680 7988514 9014606 19620853 19700373
MESH:D004827 Epilepsy Phenobarbital 6.8320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.436401628
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 11.267750514
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 11.267750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 10.433659116 15276670
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 10.433659116
MESH:D004890 Erythema Mustard Gas 5.039357497
MESH:D004916 Erythromelalgia Carbamazepine 5.5919549232
MESH:D004938 Esophageal Neoplasms Indomethacin 2.7711005569
MESH:D005076 Exanthema Carbamazepine 5.3420485159
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9111564622
MESH:D005128 Eye Diseases Toluene 2,4-Diisocyanate 5.6218447907
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.3415345470
MESH:D005234 Fatty Liver pirinixic acid 12.3420131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 12.3419224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.9516534752 16611131 16002989 16513791 15751030
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.9516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3311858732
MESH:D005334 Fever Indomethacin 4.0017627676 10431976 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4014745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0519069698
MESH:D005354 Fibrosarcoma Indomethacin 4.7610962813
MESH:D005355 Fibrosis Indomethacin 8.3917994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.3920067830
MESH:D005499 Folliculitis Indomethacin 5.0411298111
MESH:D005756 Gastritis Indomethacin 4.6215046732
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.8216452187
MESH:D005909 Glioblastoma Indomethacin 3.4812870263
MESH:D005910 Glioma Indomethacin 3.1718371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.1811849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4710696789
MESH:D006073 Gout Indomethacin 5.2211248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.6515482327
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3411294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.3416080930
MESH:D006333 Heart Failure Dobutamine 16.3217440445
MESH:D006333 Heart Failure Isoproterenol 16.3218097624
MESH:D006333 Heart Failure pirinixic acid 16.3220558911
MESH:D006333 Heart Failure Selenium 16.3217162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2111000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.4515633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.5515135802
MESH:D006529 Hepatomegaly Phenobarbital 13.6316109766
MESH:D006529 Hepatomegaly pirinixic acid 13.6318467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.6316120746 12621046 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6616863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.9015709030
MESH:D019584 Hot Flashes Estradiol 9.6217088409
MESH:D019584 Hot Flashes Vitamin E 9.6214716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.928697196 15340226 16354765 18606429 16959395
MESH:D006930 Hyperalgesia Indomethacin 3.6712727271
MESH:D034321 Hyperamylasemia Indomethacin 5.5917883296
MESH:D006940 Hyperemia Indomethacin 4.8712524144
MESH:D006943 Hyperglycemia pirinixic acid 3.0720558911
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.6110459572
MESH:D006949 Hyperlipidemias Indomethacin 4.0417546600
MESH:D006965 Hyperplasia Carbamazepine 10.8718773962
MESH:D006965 Hyperplasia Diethylstilbestrol 10.8714722030 12960047
MESH:D006967 Hypersensitivity Toluene 2,4-Diisocyanate 4.4811019492 10880147
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8618850075 18670907
MESH:D006984 Hypertrophy Isoproterenol 5.0712791704
MESH:D007021 Hypospadias Diethylstilbestrol 10.8116002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.8116945680 16569931
MESH:D007022 Hypotension Isoproterenol 4.676740701
MESH:D007077 Ileal Diseases Indomethacin 4.9018306037 10574470
MESH:D007079 Ileitis Indomethacin 5.2210647630 10651667 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.2416133044
MESH:D007246 Infertility Diethylstilbestrol 4.2315036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4017937319
MESH:D007249 Inflammation Flavonoids 15.1617296493
MESH:D007249 Inflammation Indomethacin 15.1612568917 3291741 7812673
MESH:D007249 Inflammation Mustard Gas 15.1611402378 9357497 11428620 16001271 11428647 8975870 11428631 17524151 9260866
MESH:D007249 Inflammation Tamoxifen 15.1619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.1612878042 12200463
MESH:D007251 Influenza, Human Selenium 10.5316624496
MESH:D007251 Influenza, Human Vitamin E 10.5316624496
MESH:D007333 Insulin Resistance Estradiol 6.9116393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.9116306350
MESH:D007410 Intestinal Diseases Indomethacin 4.2017329856 11855677 15610444 17994277 18236018 11686837 10210152 11713966 15831440
MESH:D019586 Intracranial Hypertension Indomethacin 5.2415241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2116580747
MESH:D007579 Jejunal Diseases Indomethacin 4.9010574470 18306037 16133968
MESH:D007674 Kidney Diseases Estradiol 9.7515618244
MESH:D007674 Kidney Diseases Indomethacin 9.7517190690
MESH:D007674 Kidney Diseases Vitamin E 9.7512488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.7616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.8916705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 16.8915003126 16762066 14681315
MESH:D007680 Kidney Neoplasms Estradiol 16.8915610895
MESH:D007680 Kidney Neoplasms Tamoxifen 16.8918625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.9317184923
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.8012228301 10320625 11703811
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.8310785260 15631656 16572323
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6118360721
MESH:D007964 Leukocytosis Indomethacin 5.2416537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.5917980183
MESH:D008064 Lipidoses Tamoxifen 3.0617567588 15342952
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.5911479899
MESH:D008103 Liver Cirrhosis Phenobarbital 2.8221047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.5314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 8.5318194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.5315474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.5318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.5312878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 8.5316169303
MESH:D008107 Liver Diseases Phenobarbital 2.1419363144
MESH:D008113 Liver Neoplasms Diethylstilbestrol 13.7116712894 15890375
MESH:D008113 Liver Neoplasms Phenobarbital 13.7121047994 8742319 19482888 19812893 19073162 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 13.7115890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 13.7116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.7116984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 5.521399818 18308698 17172636 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.5212151625
MESH:D008133 Long QT Syndrome Dobutamine 4.6419353679
MESH:D008171 Lung Diseases Dobutamine 12.0516638327
MESH:D008171 Lung Diseases Mustard Gas 12.0518161513 18702808
MESH:D008171 Lung Diseases Vitamin E 12.0516863852
MESH:D008175 Lung Neoplasms bexarotene 8.3517849452
MESH:D008175 Lung Neoplasms Indomethacin 8.3516537180 11497255 11053908
MESH:D008175 Lung Neoplasms Mustard Gas 8.353148597 8781369
MESH:D008175 Lung Neoplasms Tamoxifen 8.3518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.3511884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 8.3511062179
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.5316628512
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.0215166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.3815700306
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.0211161223
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3916002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6319428831
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 13.6115591091 19196723 19196722
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.6117203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Selenium 13.6115318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 13.6119196722 11731420 16827153 14580682 19196723
MESH:D020149 Manganese Poisoning Estradiol 12.2219453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.2219453300
MESH:D008545 Melanoma Tamoxifen 1.8619393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0515990972
MESH:D008607 Mental Retardation Carbamazepine 3.689014606
MESH:D008654 Mesothelioma Selenium 2.7415107826
MESH:D008881 Migraine Disorders Indomethacin 3.5811903285
MESH:D009062 Mouth Neoplasms Indomethacin 3.8912636206
MESH:D009135 Muscular Diseases pirinixic acid 3.3816239165
MESH:D009203 Myocardial Infarction Isoproterenol 5.8616697266 16584858 17052832 19595682 16538859 15740881 19172585
MESH:D009203 Myocardial Infarction pirinixic acid 5.8619151258
MESH:D017202 Myocardial Ischemia Dobutamine 9.0412447174
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.0412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.9116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.9116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3417484760
MESH:D009224 Myotonia Congenita Carbamazepine 5.3420399394
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.7318551238
MESH:D009362 Neoplasm Metastasis Indomethacin 5.7811239499 11053908 16537180
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.7819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4719410462
MESH:D009369 Neoplasms Diethylstilbestrol 4.8315313581
MESH:D009369 Neoplasms pirinixic acid 4.8317405874
MESH:D009374 Neoplasms, Experimental Indomethacin 9.2410663608 15625704
MESH:D009374 Neoplasms, Experimental Toluene 2,4-Diisocyanate 9.241670384
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 10.5019196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.5019196722 19200415 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6017289903
MESH:D009421 Nervous System Malformations Carbamazepine 22.4516990009
MESH:D009421 Nervous System Malformations Diethylstilbestrol 22.4511399458
MESH:D009421 Nervous System Malformations Estradiol 22.4516427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 22.4514600291
MESH:D019636 Neurodegenerative Diseases Indomethacin 3.8312349958
MESH:D009503 Neutropenia Mustard Gas 3.857688884 16761898
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.046374098
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.9712819281 16049721
MESH:D009784 Occupational Diseases Toluene 2,4-Diisocyanate 8.973040596 6091946 11077013 12585506 6091945 8156442 18394133
MESH:D010003 Osteoarthritis Indomethacin 3.597009135
MESH:D010018 Osteomalacia Carbamazepine 11.6617016548
MESH:D010018 Osteomalacia Phenobarbital 11.6617016548
MESH:D010051 Ovarian Neoplasms Estradiol 2.1819401270
MESH:D010146 Pain Carbamazepine 7.0415215642
MESH:D010146 Pain Indomethacin 7.0417627676 3291741 17440234 13679232
MESH:D010149 Pain, Postoperative Indomethacin 4.5512538197 18702446
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.4516965848
MESH:D010195 Pancreatitis Indomethacin 3.8015028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5611578682
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.5916537180
MESH:D010267 Parapsoriasis Carbamazepine 5.5716538176
MESH:D020734 Parkinsonian Disorders Indomethacin 4.0012349958
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.7917679678 17145499
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.5911903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1212520081
MESH:D010437 Peptic Ulcer Indomethacin 5.0211148446
MESH:D010518 Periodontitis Indomethacin 4.7817225004
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.0414722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.5416977796 15687265
MESH:D010954 Plasmacytoma Selenium 4.7615087411
MESH:D011041 Poisoning Mustard Gas 3.6715727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4318163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.512563599
MESH:D011248 Pregnancy Complications Carbamazepine 5.029014606
MESH:D047928 Premature Birth Indomethacin 5.0017000239
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 15.659014606
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 15.6517184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.6511399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7620887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.1015846301 15046698 17136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.1016740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1015067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.1015084515
MESH:D011507 Proteinuria Indomethacin 4.0411849393
MESH:D011537 Pruritus Ethinyl Estradiol 9.0915861022 16919318
MESH:D011537 Pruritus Mustard Gas 9.0918058305
MESH:D019310 Pseudolymphoma Carbamazepine 12.159591791 12752131
MESH:D019310 Pseudolymphoma Phenobarbital 12.1512752131
MESH:D011654 Pulmonary Edema Isoproterenol 5.1210903255
MESH:D011657 Pulmonary Eosinophilia Toluene 2,4-Diisocyanate 5.4914606601
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8817894541 17720292 17266442 17620002 10334151
MESH:D015427 Reperfusion Injury pirinixic acid 2.3219058328
MESH:D012130 Respiratory Hypersensitivity Toluene 2,4-Diisocyanate 4.3516940033 7692837 20219652
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7118990726
MESH:D012140 Respiratory Tract Diseases Toluene 2,4-Diisocyanate 4.9918447907
MESH:D012220 Rhinitis Toluene 2,4-Diisocyanate 4.4619050374
MESH:D012221 Rhinitis, Allergic, Perennial Toluene 2,4-Diisocyanate 5.1512617775 15015336
MESH:D006255 Rhinitis, Allergic, Seasonal Toluene 2,4-Diisocyanate 5.3819075512
MESH:D012640 Seizures 2,4-dinitrotoluene 9.4618551238
MESH:D012640 Seizures Carbamazepine 9.4615946322 16180713 19414003 16938433 9046859 16876388 9844417
MESH:D012640 Seizures Phenobarbital 9.4611442880 3137016 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.696407741
MESH:D012871 Skin Diseases Mustard Gas 4.9112880345 15451306 16961503
MESH:D012871 Skin Diseases Vitamin E 4.9118709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9816192470
MESH:D012893 Sleep Disorders Carbamazepine 4.9919414003
MESH:D012912 Sneezing Toluene 2,4-Diisocyanate 5.3819075512 19050374
MESH:D013088 Spermatocele Diethylstilbestrol 19.3916709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 19.3916709447
MESH:D013088 Spermatocele Tamoxifen 19.3916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9119457130
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.0818855540 15057820 20485159 19694795 16415921 19915237 16538176
MESH:D013272 Stomach Diseases Indomethacin 4.2916113693 16184426 15472012 18209964 18545984 16280098 15038085 17207306 17638125 10215738 17160473 10486359 10192188
MESH:D013274 Stomach Neoplasms Indomethacin 2.3515609394
MESH:D013276 Stomach Ulcer Indomethacin 3.4718181030 11595415 16631530 18299717 18193104 11145282 12787963 11523592 14567935 17135157 17918041 18431645 12467913 15255614 18726076 18087811 17654042 18543354 17895592 16252198 17657623 11729361 11595431 12498302 17977527 17627676 18209962 12500499 16934674 18237397 16169175 16755016 11906479 16397915 1323529 10423059 12077510 15138204 16150113 10750652 15104355 10878458
MESH:D020521 Stroke Vitamin E 3.4116517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7712697716
MESH:D013964 Thyroid Neoplasms Indomethacin 7.0711352223 18791128 14736730
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.071399818
MESH:D013978 Tibial Fractures Estradiol 4.5619048282
MESH:D016171 Torsades de Pointes Dobutamine 5.2219353679
MESH:D014456 Ulcer Indomethacin 4.7617380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.0616049721
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.0617306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.0616712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1810091137
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.9216175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.0414652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 9.0516690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.0514692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.3116002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4214671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 4.9918097624
MESH:D020257 Ventricular Remodeling Isoproterenol 5.5618097624
MESH:D014839 Vomiting Indomethacin 4.6211897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1215886252
Pathway ID Pathway Name
KEGG:04976 Bile secretion
KEGG:04062 Chemokine signaling pathway
REACT:15380 Diabetes pathways
KEGG:05414 Dilated cardiomyopathy
KEGG:04961 Endocrine and other factor-regulated calcium reabsorption
KEGG:04540 Gap junction
KEGG:04971 Gastric acid secretion
KEGG:04724 Glutamatergic synapse
KEGG:04912 GnRH signaling pathway
REACT:1505 Integration of energy metabolism
KEGG:04916 Melanogenesis
KEGG:04114 Oocyte meiosis
REACT:15295 Opioid Signalling
KEGG:04972 Pancreatic secretion
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:00230 Purine metabolism
KEGG:04970 Salivary secretion
REACT:14797 Signaling by GPCR
REACT:11061 Signalling by NGF
REACT:13685 Synaptic Transmission
KEGG:04742 Taste transduction
REACT:15518 Transmembrane transport of small molecules
KEGG:04270 Vascular smooth muscle contraction
KEGG:04962 Vasopressin-regulated water reabsorption
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27
    • No data
    No data
    Releated drug ID Related drug Name
    PA165290926fluticasone/salmeterol
    PA451300salmeterol
    PA164749238exenatide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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