AutismKB 2.0

Annotation Detail for CHKB


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Basic Information Top
Gene Symbol:CHKB ( CHETK,CHKL,CK,CKB,CKEKB,EK,EKB )
Gene Full Name: choline kinase beta
Band: 22q13.33
Quick LinksEntrez ID:1120; OMIM: 612395; Uniprot ID:CHKB_HUMAN; ENSEMBL ID: ENSG00000100288; HGNC ID: 1938
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00564Glycerophospholipid metabolism
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CHKB mRNAaffects expression 16483693
D001554 Benzene Benzene results in decreased expression of CHKB mRNAdecreases expression 15120971
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CHKB mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of CHKB mRNAincreases expression 18301758
18445702
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in decreased expression of CHKB mRNAdecreases expression 17982090
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1918287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.1116434500
MESH:D000741 Anemia, Aplastic Benzene 4.6817661222 11369114 14761424
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5719483382
MESH:D001855 Bone Marrow Diseases Benzene 5.9516183116
MESH:D001943 Breast Neoplasms Benzene 2.8517162533 11921183
MESH:D002779 Cholestasis pirinixic acid 3.1219176532
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 5.1011698051 18200517 17991707 16474422 16867261 16782535 17936198 16804969 18023891
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.5417276891
MESH:D019465 Craniofacial Abnormalities Benzene 2.4515643154
MESH:D003872 Dermatitis Benzene 5.3315902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D005234 Fatty Liver pirinixic acid 3.1920131406 19236843
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 4.9117994277
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006402 Hematologic Diseases Benzene 5.1216183116
MESH:D006529 Hepatomegaly pirinixic acid 3.5518467677 19772884 19176532 16221962
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D006973 Hypertension Benzene 3.2117940673
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.7018200517
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 5.1717994277
MESH:D007938 Leukemia Benzene 3.5617119257 18335105 15935818 14694614
MESH:D007951 Leukemia, Myeloid Benzene 4.7417506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.7419478238
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.9315890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Benzene 3.5112562636
MESH:D017563 Lung Diseases, Interstitial Benzene 5.5314698565
MESH:D008175 Lung Neoplasms Benzene 2.4312562636
MESH:D008223 Lymphoma Benzene 4.0117119257 17584886
MESH:D015674 Mammary Neoplasms, Animal Benzene 5.0712562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 3.5411921183
MESH:D009101 Multiple Myeloma Benzene 3.9417119195
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D009290 Narcolepsy marker/mechanism 18820697
MESH:D009369 Neoplasms pirinixic acid 2.1117405874
MESH:D009436 Neural Tube Defects Benzene 3.9115643154
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D009784 Occupational Diseases Benzene 4.5715576619 15913788 17479406 16737584 17178637 15612468 15727169 15935809 17119257
MESH:D010051 Ovarian Neoplasms Benzene 3.0612562636
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.6617698068
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D013274 Stomach Neoplasms Benzene 2.4212562636
MESH:D013953 Thymus Neoplasms Benzene 5.5910850423
MESH:D014594 Uterine Neoplasms Benzene 4.8412562636
Pathway ID Pathway Name
KEGG:00564 Glycerophospholipid metabolism
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26469
    • No data
    Releated disease ID Related disease Name
    PA445042Narcolepsy
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00122 - Choline Dietary supplement;Micronutrient;Nootropic Agents;Lipotropic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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