Annotation Detail for POLI
Basic Information
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| Desease ID | Desease Name |
|---|
| 1712 | Yersinia infection |
| 1944 | Breast cancer |
| 2239 | Lymphoma |
| Desease Name |
|---|
| CANCER |
| Neoplasms |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D000082 |
Acetaminophen |
Acetaminophen affects the expression of POLI mRNA | affects expression | 17562736
|
| C006253 |
pirinixic acid |
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of POLI mRNA | affects binding|decreases expression|increases activity | 19710929
|
| D014810 |
Vitamin E |
Vitamin E results in decreased expression of POLI mRNA | decreases expression | 19244175
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.64 | 18653653 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
4.22 | 16434500 |
| MESH:D000799 |
Angioedema |
|
Acetaminophen |
4.71 | 10982225 |
| MESH:D001321 |
Autistic Disorder |
|
Acetaminophen |
1.39 | 18445737 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.63 | 19483382 |
| MESH:D002252 |
Carbon Tetrachloride Poisoning |
|
Vitamin E |
4.58 | 16050911 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Acetaminophen |
1.41 | 3084413 |
| MESH:D002386 |
Cataract |
|
Acetaminophen |
2.81 | 10977129 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.15 | 19176532 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Vitamin E |
1.93 | 19769572 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.59 | 18249437 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Acetaminophen |
1.68 | 15619225 16081117 16485898 12705907 17562736 11287661 11529661 19739265 16393943 11743745 15968718 12958197 19164858 14725611 2444490 10915739 10663392 16781746 12594235 16227642 19370779 16109766 12540782 11834606 17522070 18713872 19420014 19416960 12153990 11461765 12392966 17906064 14550746 16177239 19923254 18071297 10774834 19085960 11421492 11739529 14986274 |
| MESH:D056487 |
Drug-Induced Liver Injury, Chronic |
|
Acetaminophen |
4.96 | 19426721 |
| MESH:C538011 |
Eales disease |
|
Vitamin E |
5.57 | 9068938 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.96 | 12083418 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
3.25 | 19236843 20131406 |
| MESH:D005756 |
Gastritis |
|
Acetaminophen |
4.54 | 16983495 |
| MESH:D006330 |
Heart Defects, Congenital |
|
Vitamin E |
3.18 | 16080930 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.78 | 20558911 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.64 | 16221962 19772884 18467677 19176532 |
| MESH:D006548 |
Hernia, Diaphragmatic |
|
Vitamin E |
2.82 | 16490937 16863852 |
| MESH:D019584 |
Hot Flashes |
|
Vitamin E |
4.84 | 14716179 |
| MESH:D006930 |
Hyperalgesia |
|
Acetaminophen |
3.06 | 16870215 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.63 | 20558911 |
| MESH:D007251 |
Influenza, Human |
|
Vitamin E |
5.08 | 16624496 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.90 | 16306350 |
| MESH:D007674 |
Kidney Diseases |
|
Acetaminophen |
6.72 | 15629191 12587719 |
| MESH:D007674 |
Kidney Diseases |
|
Vitamin E |
6.72 | 12488133 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
2.48 | 15474484 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Vitamin E |
2.48 | 16169303 |
| MESH:D008107 |
Liver Diseases |
|
Acetaminophen |
1.71 | 19014921 16611625 19460945 16610002 11587558 19784758 12587719 12969438 |
| MESH:D017114 |
Liver Failure, Acute |
|
Acetaminophen |
3.68 | 16871587 17185352 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
1.94 | 20007298 15890375 16377806 |
| MESH:D008171 |
Lung Diseases |
|
Vitamin E |
3.45 | 16863852 |
| MESH:D008175 |
Lung Neoplasms |
|
Vitamin E |
1.90 | 11062179 |
| MESH:D008546 |
Melanoma, Experimental |
|
Acetaminophen |
4.22 | 19513568 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
4.16 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.29 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.29 | 16411023 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.12 | 17405874 |
| MESH:D019636 |
Neurodegenerative Diseases |
|
Acetaminophen |
3.26 | 18514411 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.89 | 20558911 |
| MESH:D010146 |
Pain |
|
Acetaminophen |
2.77 | 16870215 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Vitamin E |
3.24 | 15084515 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.56 | 19058328 |
| MESH:D012871 |
Skin Diseases |
|
Vitamin E |
2.52 | 18709164 |
| MESH:D020521 |
Stroke |
|
Vitamin E |
3.88 | 16517955 |
| MESH:D014581 |
Urticaria |
|
Acetaminophen |
3.50 | 10982225 |
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