Annotation Detail for CHM
Basic Information
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| Gene Symbol: | CHM ( DXS540,FLJ38564,GGTA,HSD-32,MGC102710,REP-1,TCD ) |
|---|
| Gene Full Name: | choroideremia (Rab escort protein 1) |
|---|
| Band: | Xq21.2 |
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| Quick Links | Entrez ID:1121; OMIM: 300390; Uniprot ID:RAE1_HUMAN; ENSEMBL ID: ENSG00000188419; HGNC ID: 1940 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Desease ID | Desease Name |
|---|
| 1808 | Eye disease |
| 2120 | Rabies |
| 2259 | Hereditary disease |
| Desease Name |
|---|
| Choroideremia |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D000643 |
Ammonium Chloride |
Ammonium Chloride affects the expression of CHM mRNA | affects expression | 16483693
|
| D002251 |
Carbon Tetrachloride |
Carbon Tetrachloride results in increased expression of CHM protein | increases expression | 12629582
|
| D003010 |
Clorgyline |
Clorgyline results in increased expression of CHM mRNA | increases expression | 19691856
|
| D005839 |
Gentamicins |
Gentamicins results in increased expression of CHM protein mutant form | increases expression | 18809619
|
| D010303 |
Paromomycin |
Paromomycin results in increased expression of CHM protein mutant form | increases expression | 18809619
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000138 |
Acidosis |
|
Ammonium Chloride |
4.10 | 18287403 |
| MESH:D058186 |
Acute Kidney Injury |
|
Gentamicins |
4.91 | 11274264 |
| MESH:D002252 |
Carbon Tetrachloride Poisoning |
|
Carbon Tetrachloride |
4.26 | 16097048 15673190 18705752 3786805 16192424 15700767 16050911 10355542 16124888 16227642 16011737 15721981 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Carbon Tetrachloride |
1.86 | 18788625 |
| MESH:D015794 |
Choroideremia |
marker/mechanism |
|
| |
| MESH:D003457 |
Cryptosporidiosis |
|
Paromomycin |
7.70 | 16547730 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Carbon Tetrachloride |
2.11 | 15027814 10915739 7179309 4309450 19336974 6623471 11566570 21278145 6884620 7120509 2869522 9327722 10092053 3732212 15968718 17522070 3786805 7440962 16177239 16227642 19085960 15998439 |
| MESH:D004362 |
Drug Toxicity |
|
Gentamicins |
4.70 | 11033412 15033597 |
| MESH:D005234 |
Fatty Liver |
|
Carbon Tetrachloride |
3.54 | 19224547 12795759 61145 15959796 12631006 17595544 16045604 16239168 |
| MESH:D005355 |
Fibrosis |
|
Carbon Tetrachloride |
3.94 | 18705752 |
| MESH:D034381 |
Hearing Loss |
|
Gentamicins |
5.21 | 15968427 18024279 17868369 19130971 |
| MESH:D006505 |
Hepatitis |
|
Carbon Tetrachloride |
4.03 | 19110552 19900420 |
| MESH:D006932 |
Hyperbilirubinemia |
|
Carbon Tetrachloride |
5.07 | 16899240 |
| MESH:D053565 |
Hypercalciuria |
|
Gentamicins |
6.25 | 17652376 |
| MESH:D006975 |
Hypertension, Portal |
|
Carbon Tetrachloride |
4.57 | 15338365 |
| MESH:D007673 |
Kidney Cortex Necrosis |
|
Gentamicins |
6.34 | 18842672 |
| MESH:D007674 |
Kidney Diseases |
|
Gentamicins |
4.01 | 18289764 19349640 17934191 |
| MESH:D007683 |
Kidney Tubular Necrosis, Acute |
|
Gentamicins |
5.99 | 11231351 |
| MESH:D016773 |
Leishmaniasis, Cutaneous |
|
Gentamicins |
10.61 | 10219319 |
| MESH:D016773 |
Leishmaniasis, Cutaneous |
|
Paromomycin |
10.61 | 8889330 10219319 7570843 |
| MESH:D007898 |
Leishmaniasis, Visceral |
|
Paromomycin |
5.94 | 8394861 17035822 |
| MESH:D008103 |
Liver Cirrhosis |
|
Carbon Tetrachloride |
2.98 | 17157831 11408273 21278145 16943688 11903743 16221502 16239168 17334410 17174718 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Carbon Tetrachloride |
1.75 | 17721639 18210741 12741479 15673190 17761835 18277467 16192424 15730626 14716833 18472094 13678700 16015684 15876570 12546737 15996030 14716496 18187930 14748882 15959796 12898905 17525996 12632514 17714472 17557913 18418968 16136751 18420326 17708605 17766677 17869086 18205269 18472332 17900296 17481882 16011737 17805973 15818738 12666154 17976157 15338365 17631135 18412020 17640975 18395914 18429990 16248980 18376398 17823541 12958196 18705752 16033810 15650968 12445421 12389079 18279442 18166357 12586293 17944888 16027843 11481614 15362042 17565644 15123356 14620537 12609069 17922224 18395095 17698563 12667390 14724832 18263696 14512876 18339082 15370692 18251166 18481824 10355542 15057751 16097048 15925388 18156304 20821823 12632512 12649538 15931870 18317297 18006644 16638106 15893842 12445418 16116963 15052691 18054572 |
| MESH:D008107 |
Liver Diseases |
|
Carbon Tetrachloride |
2.15 | 16246199 16964402 15720792 17285989 15830285 |
| MESH:D017093 |
Liver Failure |
|
Carbon Tetrachloride |
4.65 | 15123358 |
| MESH:D017114 |
Liver Failure, Acute |
|
Carbon Tetrachloride |
4.04 | 16899240 14706259 |
| MESH:D008113 |
Liver Neoplasms |
|
Carbon Tetrachloride |
2.32 | 19294768 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
Carbon Tetrachloride |
2.81 | 15583823 12014681 |
| MESH:D009137 |
Muscular Dystrophy, Animal |
|
Gentamicins |
6.89 | 18694830 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Clorgyline |
4.23 | 19691856 |
| MESH:D011507 |
Proteinuria |
|
Gentamicins |
5.12 | 15033597 |
| MESH:D051437 |
Renal Insufficiency |
|
Gentamicins |
5.48 | 15728788 17132701 |
| MESH:D012173 |
Retinitis |
|
Gentamicins |
6.89 | 18644591 |
| MESH:D015837 |
Vestibular Diseases |
|
Gentamicins |
5.96 | 18776599 |
| Drugbank ID |
Action |
Drug Name |
Description |
|---|
| DB07752 |
- |
FARNESYL |
|
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