AutismKB 2.0

Annotation Detail for AKAP13


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Basic Information Top
Gene Symbol:AKAP13 ( AKAP-Lbc,ARHGEF13,BRX,FLJ11952,FLJ43341,HA-3,Ht31,LBC,PROTO-LB,PROTO-LBC,c-lbc )
Gene Full Name: A kinase (PRKA) anchor protein 13
Band: 15q25.3
Quick LinksEntrez ID:11214; OMIM: 604686; Uniprot ID:AKP13_HUMAN; ENSEMBL ID: ENSG00000170776; HGNC ID: 371
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Signaling by Rho GTPases
Pathway IDPathway Name
200050Regulation of RhoA activity
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1850Herpes
1901Endometriosis
1944Breast cancer
1986Eating disorder
2051Leukemia
Desease Name
CHEMDEPENDENCY
CANCER
breast cancer
smoking cessation
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of AKAP13 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of AKAP13 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of AKAP13 mRNAincreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AKAP13 mRNAdecreases expression 19150397
20018196
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of AKAP13 mRNAdecreases expression 20713471
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of AKAP13 mRNAaffects binding|increases activity|increases expression 19710929
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of AKAP13 mRNAaffects cotreatment|increases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of AKAP13 mRNAaffects expression 17440010
C025643 vinclozolin vinclozolin affects the expression of AKAP13 mRNAaffects expression 19015723
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of AKAP13 mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of AKAP13 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3211798837 19825857
MESH:D000236 Adenoma Methylcholanthrene 3.5910545420 6695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7819015723
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5511922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.5816206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5819483382
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.8617474063
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1516050911
MESH:D002277 Carcinoma Methylcholanthrene 4.1010545420
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.673084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.6716217749 14691202 15553829 11135700 15073043
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.956135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.9520889678
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 11.9516192471
MESH:D002779 Cholestasis pirinixic acid 2.9519176532
MESH:D003092 Colitis Selenium 3.9917936198
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7510525206
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7519769572
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4617562736 11461765 16177239 19416960 2444490 11834606 11421492 12153990 19085960 19739265 16393943 14725611 15968718 14986274 16081117 12540782 17522070 10915739 19370779 12705907 16485898 11529661 19923254 17906064 12958197 11287661 16109766 18071297 12594235 14550746 12392966 16227642 19164858 10663392 18713872 16781746 11739529 11743745 19420014 15619225 10774834
MESH:D056486 Drug-Induced Liver Injury Selenium 6.4615131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004938 Esophageal Neoplasms marker/mechanism 17068819
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5920426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5912903497
MESH:D005234 Fatty Liver arsenic trioxide 8.3015073043
MESH:D005234 Fatty Liver pirinixic acid 8.3019236843 20131406
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.1814633661 10962813
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0716080930
MESH:D006333 Heart Failure pirinixic acid 7.2820558911
MESH:D006333 Heart Failure Selenium 7.2817162251
MESH:D006529 Hepatomegaly pirinixic acid 3.2118467677 19772884 16221962 19176532
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516863852 16490937
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.0117440010
MESH:D019584 Hot Flashes Vitamin E 4.2414716179
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D007248 Infertility, Male vinclozolin 3.1516467254
MESH:D007251 Influenza, Human Selenium 11.8616624496
MESH:D007251 Influenza, Human Vitamin E 11.8616624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007674 Kidney Diseases Acetaminophen 6.2715629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.2712488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.1216705839
MESH:D007938 Leukemia arsenic trioxide 2.9115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9717077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1620471514 17050201 16467208 16968895 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3216330433 9834237 12679006 16331271 17217047 11468182 17869043 12712474 15622746 16112521 19075265 12018890 17649720 15336539 15213294 17107899 16823087 17712046 19225113 15748426 16966277 16891316 11161223 19642359 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4215474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4216169303
MESH:D008107 Liver Diseases Acetaminophen 1.6616611625 16610002 19784758 12587719 19460945 11587558 19014921 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.757678174
MESH:D008113 Liver Neoplasms arsenic trioxide 7.7514682389
MESH:D008113 Liver Neoplasms pirinixic acid 7.7520007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.562876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.5620377131
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 10.561399818 598648
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D008171 Lung Diseases Vitamin E 3.2916863852
MESH:D008175 Lung Neoplasms arsenic trioxide 3.6519825857 11798837
MESH:D008175 Lung Neoplasms Methylcholanthrene 3.6516271038 15390079 20970405 7750092 20512841 16337739 10545420 9230183 6695378 21163286 11893704 1399818 17909032
MESH:D008175 Lung Neoplasms Vitamin E 3.6511062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8615318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008654 Mesothelioma Selenium 2.8515107826
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2211468182 14977855 15949261 19417148 19549372
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2316105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.107678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2210525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5916049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4516624393 19769630 12452020
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.1319015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2619131511
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2615084515
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6418551238
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D020521 Stroke Vitamin E 3.6616517955
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2219014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2816049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.2820435036 12845720 11780464 12973940
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5610091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
Pathway ID Pathway Name
REACT:14797 Signaling by GPCR
REACT:11044 Signaling by Rho GTPases
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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