AutismKB 2.0

Annotation Detail for AKAP2


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Basic Information Top
Gene Symbol:AKAP2 ( AKAP-2,AKAPKL,DKFZp564L0716,FLJ53197,FLJ98336,PALM2,PRKA2 )
Gene Full Name: A kinase (PRKA) anchor protein 2
Band: 9q31.3
Quick LinksEntrez ID:11217; OMIM: 604582; Uniprot ID:AKAP2_HUMAN; ENSEMBL ID: ENSG00000157654,ENSG00000241978; HGNC ID: 372
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of AKAP2 mRNAaffects expression 17562736
D004958 Estradiol Estradiol results in decreased expression of AKAP2 mRNAdecreases expression 20068009
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AKAP2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AKAP2 mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin results in decreased expression of AKAP2 mRNAdecreases expression 16604517
D014635 Valproic Acid Valproic Acid results in increased expression of AKAP2 mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of AKAP2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.6614514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.668875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2119490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Estradiol 4.4111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4114692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D000550 Amblyopia Valproic Acid 5.6817688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001008 Anxiety Disorders Valproic Acid 9.6117497229
MESH:D001008 Anxiety Disorders vinclozolin 9.6119015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.7315885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.7316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4116456186
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8615238991 19460635 18558336 18177632 18985861 18396377 20603192 19232924 17507914 18940202 17157402 16609825 18316065 18775368 17688650
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.2020046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.8912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.8916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.5715746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.578888407
MESH:D001943 Breast Neoplasms Estradiol 1.8216675129 17018787 12948864 14630087 17289903 19861407 17261762 18497071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8220435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8216873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.733084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7316924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.731917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3516051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 7.7210977129
MESH:D002386 Cataract Tretinoin 7.7217460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9518566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7920734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0711677210 17681005 16919318 16105132 17110522 15861022 17333356
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0915668235 16354765 12621046 8697196 15340226
MESH:D002972 Cleft Palate Tretinoin 6.099407595
MESH:D003092 Colitis Tretinoin 4.0617035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8920055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.8914991402 16925845 9664655 9211117 10589399 9142499 17551590 9125849 8800419 9224671
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.898888407 16575769 17688650
MESH:D003456 Cryptorchidism vinclozolin 4.6714966744
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.6619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5419416960 11743745 17906064 11739529 16177239 18713872 11461765 10663392 15968718 11287661 19085960 10915739 19739265 11529661 14725611 12705907 16081117 18071297 16781746 17562736 16109766 14986274 14550746 12540782 19164858 12958197 15619225 12392966 11834606 16485898 12594235 12153990 19370779 17522070 2444490 16227642 10774834 19420014 16393943 19923254 11421492
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5420420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.541733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004421 Dystonia Valproic Acid 4.351851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 13.4718230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 13.4718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D016889 Endometrial Neoplasms Estradiol 7.9819148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tretinoin 7.9816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.5117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.363922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0618234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.847562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.667750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.463659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.5211564622
MESH:D005124 Eye Abnormalities Tretinoin 9.5216938888 9664655
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.7015345470
MESH:D005234 Fatty Liver Valproic Acid 8.7014986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005315 Fetal Diseases Valproic Acid 5.3316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.4618558336 8888407
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.8420067830
MESH:D005355 Fibrosis Tretinoin 9.8417994277
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.3316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.7416417039
MESH:D005909 Glioblastoma Tretinoin 3.1717312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9710048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.9714991402 9664655
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2515340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006849 Hydrocephalus Valproic Acid 5.2617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4918606429 16959395 8697196 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 8.3716870215
MESH:D006930 Hyperalgesia Tretinoin 8.3716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.2517937319
MESH:D007248 Infertility, Male vinclozolin 7.2516467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812200463 12878042
MESH:D007333 Insulin Resistance Estradiol 3.1316393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.8916580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.8915992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 6.3712587719 15629191
MESH:D007674 Kidney Diseases Estradiol 6.3715618244
MESH:D007680 Kidney Neoplasms Estradiol 3.2115610895
MESH:D007938 Leukemia Tretinoin 2.8917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9816482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0219850784 17596541 16294345
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0217596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3216935935 16766008 19225113 17506722 16823087 17368321 19029980 17712046 17294898 15748426 17649720 9834237 16788101 16331271 17301526 12679006 17361223 16140955 19642359 17217047 19035177 16891316 19075265 17339181 17107899
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1316417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5816248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6819784758 16611625 19014921 12969438 19460945 16610002 12587719 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8016984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7017228818
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7211807958 16891317 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D008881 Migraine Disorders Valproic Acid 3.3818765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.318888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.8717596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.8717596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D009369 Neoplasms Tretinoin 2.5216946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations Estradiol 18.3416427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 18.3414600291
MESH:D009421 Nervous System Malformations Tretinoin 18.349125849
MESH:D009436 Neural Tube Defects Tretinoin 7.889142499
MESH:D009436 Neural Tube Defects Valproic Acid 7.888888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D010051 Ovarian Neoplasms Estradiol 5.0419401270
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0416936753
MESH:D010146 Pain Acetaminophen 7.3716870215
MESH:D010146 Pain Tretinoin 7.3716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5415976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 18.6911896295 11118676 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 18.6920603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 18.6918220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.3318220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0416740699
MESH:D011472 Prostatitis vinclozolin 5.3318629315
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.9812752131 11422049
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.9016283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 11.9019155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.9114763951 11044598 1511512 3137016 15475178 16876388 11738929 17978042
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9416192470
MESH:D012878 Skin Neoplasms Tretinoin 5.9416467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9812833885
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2317045167 16026305
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.6817262798
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.923119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.008888407
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9416129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D014604 Uveal Neoplasms Tretinoin 5.0516752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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