AutismKB 2.0

Annotation Detail for DUSP10


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Basic Information Top
Gene Symbol:DUSP10 ( MKP-5,MKP5 )
Gene Full Name: dual specificity phosphatase 10
Band: 1q41
Quick LinksEntrez ID:11221; OMIM: 608867; Uniprot ID:DUS10_HUMAN; ENSEMBL ID: ENSG00000143507; HGNC ID: 3065
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
No data
Pathway IDPathway Name
200116ATF-2 transcription factor network
200054Regulation of p38-alpha and p38-beta
Pathway IDPathway Name
P00046Oxidative stress response
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in increased expression of DUSP10 mRNAincreases expression 15982314
D000082 Acetaminophen Acetaminophen affects the expression of DUSP10 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DUSP10 proteinaffects expression 20106945
C103303 alitretinoin alitretinoin results in increased expression of DUSP10 mRNAincreases expression 15982314
C061133 Am 80 Am 80 results in decreased expression of DUSP10 mRNAdecreases expression 17229644
D000638 Amiodarone Amiodarone results in increased expression of DUSP10 mRNAincreases expression 19774075
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of DUSP10 mRNAincreases expression 18687144
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of DUSP10 mRNAincreases expression 15336504
D003474 Curcumin Curcumin results in increased expression of DUSP10 mRNAincreases expression 17151092
15713895
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of DUSP10 mRNAincreases expression 17654400
D016572 Cyclosporine Cyclosporine results in increased expression of DUSP10 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of DUSP10 mRNAincreases expression 18042831
D002117 Calcitriol Calcitriol results in increased expression of DUSP10 mRNAincreases expression 16002434
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DUSP10 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of DUSP10 mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of DUSP10 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DUSP10 mRNAaffects cotreatment|increases expression 17942748
C007845 gingerol gingerol results in increased expression of DUSP10 mRNAincreases expression 17151092
C002950 methylformamide methylformamide affects the expression of DUSP10 mRNAaffects expression 17040096
C002950 methylformamide methylformamide analog affects the expression of DUSP10 mRNAaffects expression 17040096
C008493 methylselenic acid methylselenic acid results in increased expression of DUSP10 mRNAincreases expression 12517777
C041786 palm oil palm oil results in increased expression of DUSP10 mRNAincreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DUSP10 mRNAaffects binding|decreases expression|increases activity 19710929
C031280 pyrazole pyrazole results in increased expression of DUSP10 mRNAincreases expression 17945193
C059514 resveratrol resveratrol results in increased expression of DUSP10 mRNAincreases expression 17151092
D015474 Isotretinoin Isotretinoin results in increased expression of DUSP10 mRNAincreases expression 15982314
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DUSP10 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DUSP10 mRNAincreases expression 19619570
20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DUSP10 mRNAaffects cotreatment|increases expression 17942748
C024746 tobacco tar tobacco tar results in decreased expression of DUSP10 mRNAdecreases expression 19559774
D014212 Tretinoin Tretinoin metabolite results in increased expression of DUSP10 mRNAincreases expression 15982314
D014212 Tretinoin Tretinoin results in increased expression of DUSP10 mRNAincreases expression 15982314
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 8.0018769834
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.0014514962 11752688 15322242
MESH:D000015 Abnormalities, Multiple Isotretinoin 4.7918769834
MESH:D017486 Acneiform Eruptions Isotretinoin 6.0716232082
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 11.2917505938
MESH:D000152 Acne Vulgaris Isotretinoin 11.2918769834 16185265
MESH:D058186 Acute Kidney Injury resveratrol 3.6616538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.9218653653
MESH:D000230 Adenocarcinoma Estradiol 4.0411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.0414692618
MESH:D000236 Adenoma resveratrol 3.2015688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.2016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.2016835633
MESH:D019973 Alcohol-Related Disorders Curcumin 4.8717887948
MESH:D000505 Alopecia Tretinoin 3.4515955085
MESH:D000544 Alzheimer Disease Curcumin 4.2815590663
MESH:D000544 Alzheimer Disease resveratrol 4.2816162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D000799 Angioedema Acetaminophen 3.6310982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.6218218290 20041841 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 9.2215238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.2211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.5315885639
MESH:D001169 Arthritis, Experimental resveratrol 11.5317115116
MESH:D001169 Arthritis, Experimental Tretinoin 11.5316412693
MESH:D001172 Arthritis, Rheumatoid Am 80 7.3216819260
MESH:D001172 Arthritis, Rheumatoid Curcumin 7.3216807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 7.3216292516
MESH:D001249 Asthma Tretinoin 2.2816456186
MESH:D050197 Atherosclerosis Am 80 10.5416484594
MESH:D050197 Atherosclerosis Curcumin 10.5418704882
MESH:D050197 Atherosclerosis resveratrol 10.5417967414 16873680
MESH:D001281 Atrial Fibrillation Amiodarone 3.7518651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001327 Autoimmune Diseases Curcumin 4.2819761891
MESH:D001471 Barrett Esophagus Tretinoin 4.2016935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 20.4019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 20.4019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 20.4012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 20.4016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D002545 Brain Ischemia Curcumin 9.6216770732
MESH:D002545 Brain Ischemia resveratrol 9.6217600658
MESH:D001932 Brain Neoplasms Curcumin 3.7617596214
MESH:D001943 Breast Neoplasms alitretinoin 5.6216344269
MESH:D001943 Breast Neoplasms Calcitriol 5.6211237771
MESH:D001943 Breast Neoplasms Curcumin 5.6219250217 18462866 16243823 18593918
MESH:D001943 Breast Neoplasms Dietary Fats 5.6220435547
MESH:D001943 Breast Neoplasms Estradiol 5.6219861407 12948864 18497071 17289903 17018787 16675129 14630087 17261762
MESH:D001943 Breast Neoplasms gingerol 5.6217683926
MESH:D001943 Breast Neoplasms resveratrol 5.6217534123 17651959 16393696
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.6220435547
MESH:D001943 Breast Neoplasms Tretinoin 5.6216166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3816813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2516111702
MESH:D002277 Carcinoma Curcumin 7.7418593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.7416835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9516168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.493084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.4912907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.4916924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 8.4919321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.491917145
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.3816675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9118414057
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 13.7011237771
MESH:D002294 Carcinoma, Squamous Cell Curcumin 13.7018462866
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 13.7011237771
MESH:D002294 Carcinoma, Squamous Cell resveratrol 13.7016227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 13.7016096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2518850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8215710769 19225199
MESH:D002318 Cardiovascular Diseases resveratrol 3.3315458977
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.8718974383
MESH:D002386 Cataract Acetaminophen 6.8210977129
MESH:D002386 Cataract Tretinoin 6.8217460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.4712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.4718566989
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 10.4719559774
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D002779 Cholestasis Cyclosporine 12.4519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.4516919318 17110522 16105132 11677210 17681005 17333356 15861022
MESH:D002779 Cholestasis pirinixic acid 12.4519176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4712621046 15340226 15668235 16354765 8697196
MESH:D002972 Cleft Palate Tretinoin 5.479407595
MESH:D003092 Colitis Curcumin 14.9016782535 18200517 16804969
MESH:D003092 Colitis resveratrol 14.9016474422
MESH:D003092 Colitis Tretinoin 14.9017035595
MESH:D003103 Coloboma Curcumin 4.3618809619
MESH:D003110 Colonic Neoplasms Curcumin 3.8816340194 19359593
MESH:D003110 Colonic Neoplasms resveratrol 3.8816338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8817141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.6918497527
MESH:D003327 Coronary Disease resveratrol 3.6216507316
MESH:D019465 Craniofacial Abnormalities Isotretinoin 3.779879862 18769834
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7710048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.779211117 17551590 9142499 10589399 9224671 16925845 14991402 8800419 9664655 9125849
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3318249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.6016873680
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.2318403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2317107852
MESH:D003928 Diabetic Nephropathies Curcumin 14.0818204486
MESH:D003928 Diabetic Nephropathies Estradiol 14.0819279558
MESH:D003928 Diabetic Nephropathies resveratrol 14.0816286809
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.3610663392 17906064 11529661 18071297 16227642 16109766 16393943 17522070 14550746 12705907 12540782 12958197 12594235 15968718 19370779 19085960 14986274 16177239 11739529 10915739 12392966 11287661 15619225 16081117 11834606 11421492 18713872 14725611 12153990 19416960 16485898 11461765 10774834 19739265 17562736 16781746 19923254 11743745 2444490 19420014 19164858
MESH:D056486 Drug-Induced Liver Injury Amiodarone 11.3618218290 15265979
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 11.3617654400
MESH:D056486 Drug-Induced Liver Injury pyrazole 11.3612499123
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.3620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6111462148
MESH:D004381 Duodenal Ulcer Curcumin 3.8517351913
MESH:D050171 Dyslipidemias Dietary Fats 3.3018367378
MESH:D004487 Edema pirinixic acid 10.3412083418
MESH:D004487 Edema resveratrol 10.348985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.3412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.2315322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.2318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Am 80 20.3516819260
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 20.3515138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 20.3512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 20.3517872969
MESH:D016889 Endometrial Neoplasms Estradiol 6.9618566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Tretinoin 6.9616569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8410568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.6417923197
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.329664655 16938888
MESH:D005234 Fatty Liver Amiodarone 28.2514986274
MESH:D005234 Fatty Liver Curcumin 28.2519297423
MESH:D005234 Fatty Liver Cyclosporine 28.2519224547
MESH:D005234 Fatty Liver Dietary Fats 28.2517967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.2515345470
MESH:D005234 Fatty Liver pirinixic acid 28.2520131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D005355 Fibrosis Curcumin 25.5318705752
MESH:D005355 Fibrosis Cyclosporine 25.5312168785 12639820
MESH:D005355 Fibrosis Dietary Fats 25.5318296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 25.5320067830
MESH:D005355 Fibrosis Tretinoin 25.5317994277
MESH:D005756 Gastritis Acetaminophen 3.4616983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.4918462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.018708960
MESH:D005909 Glioblastoma Curcumin 6.8417596214
MESH:D005909 Glioblastoma Tretinoin 6.8417312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006258 Head and Neck Neoplasms Curcumin 7.4318462866 18829502
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.4316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9516084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.179664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.4120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006529 Hepatomegaly Amiodarone 13.2215265979
MESH:D006529 Hepatomegaly pirinixic acid 13.2219176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.2215340226 16120746 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.8317701891
MESH:D006558 Herpes Genitalis Estradiol 4.8215709030
MESH:D006561 Herpes Simplex resveratrol 3.9716876885
MESH:D019584 Hot Flashes Estradiol 3.5417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8315340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 7.0816870215
MESH:D006930 Hyperalgesia Tretinoin 7.0816870215
MESH:D006937 Hypercholesterolemia Amiodarone 20.268137927 9751232
MESH:D006937 Hypercholesterolemia Curcumin 20.2618704882
MESH:D006937 Hypercholesterolemia Dietary Fats 20.2621332399
MESH:D006937 Hypercholesterolemia resveratrol 20.2617188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3616778211
MESH:D006943 Hyperglycemia pirinixic acid 3.0020558911
MESH:D006949 Hyperlipidemias Dietary Fats 8.6421332399
MESH:D006949 Hyperlipidemias resveratrol 8.6416873680
MESH:D006973 Hypertension Cyclosporine 4.6810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6818670907 18850075
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1217488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6016569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 4.3117991464 18020914
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.4417600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3517937319
MESH:D007249 Inflammation therapeutic 17151092
MESH:D007249 Inflammation Curcumin 11.1018403477 16956363 17151092
MESH:D007249 Inflammation Dietary Fats 11.1020412841
MESH:D007249 Inflammation resveratrol 11.1016366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.1012200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1318200517 18596194
MESH:D007251 Influenza, Human resveratrol 4.3316624496
MESH:D007333 Insulin Resistance Dietary Fats 11.5118457598 11836018
MESH:D007333 Insulin Resistance Estradiol 11.5116393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.5116306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5617994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.0410783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.3015992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2315604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.4316144296
MESH:D007674 Kidney Diseases Acetaminophen 9.2815629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.2818776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 9.2815618244
MESH:D007680 Kidney Neoplasms Cyclosporine 6.7112371664
MESH:D007680 Kidney Neoplasms Estradiol 6.7115610895
MESH:D007889 Leiomyoma Curcumin 4.3818555241
MESH:D007938 Leukemia Curcumin 6.1518462866
MESH:D007938 Leukemia Tretinoin 6.1517143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.0216106398
MESH:D007951 Leukemia, Myeloid Tretinoin 3.5119285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0416294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Am 80 12.1916819260 16531727
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 12.1916087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 12.1917649720 16331271 16823087 16766008 19642359 15748426 19035177 19029980 17294898 12679006 17712046 17301526 9834237 16140955 17339181 17217047 16788101 17368321 17107899 17506722 17361223 16935935 19225113 19075265 16891316
MESH:D015458 Leukemia, T-Cell Curcumin 4.5616106398
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.169224671
MESH:D008064 Lipidoses Amiodarone 3.3617567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 2.7618296743
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 6.4418705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.4414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.4416248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 3.9119784758 16610002 19014921 12969438 19460945 16611625 12587719 11587558
MESH:D008107 Liver Diseases Curcumin 3.9116956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0516871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 10.0315890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms pirinixic acid 10.0320007298 16377806 15890375
MESH:D008113 Liver Neoplasms resveratrol 10.0319321006 19812893 20405173 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.0316984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.388603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.3812151625
MESH:D008133 Long QT Syndrome Amiodarone 3.4217391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.2412587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.2718516814
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.8217365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.3414755239
MESH:D008175 Lung Neoplasms alitretinoin 6.3416413115
MESH:D008175 Lung Neoplasms Curcumin 6.3419359593 18462866 16243823
MESH:D008175 Lung Neoplasms Isotretinoin 6.3415899809
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.3411884234 19555203
MESH:D008223 Lymphoma Curcumin 3.4418462866
MESH:D016393 Lymphoma, B-Cell resveratrol 4.1017088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.7014749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.4916173963
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.0415688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.7116891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 5.718985016 11606380
MESH:D020149 Manganese Poisoning Estradiol 4.2719453300
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Curcumin 7.0617885582 18462866
MESH:D008545 Melanoma Isotretinoin 7.0617237267
MESH:D008545 Melanoma resveratrol 7.0617992120
MESH:D008545 Melanoma Tretinoin 7.0616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3619513568
MESH:D008569 Memory Disorders Curcumin 3.9517263510
MESH:D008591 Meningomyelocele Tretinoin 4.2216940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1016966607 16166281 18303189
MESH:D008659 Metabolic Diseases resveratrol 4.1917112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5816801185
MESH:D009101 Multiple Myeloma Am 80 11.5417229644
MESH:D009101 Multiple Myeloma Curcumin 11.5419372569
MESH:D009101 Multiple Myeloma resveratrol 11.5417049120 17935668 16490592 17164350 14749477 16267019
MESH:D009134 Muscular Atrophy, Spinal Curcumin 11.7117962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 11.7117962980
MESH:D009135 Muscular Diseases pirinixic acid 3.3016239165
MESH:D009181 Mycoses Amiodarone 4.6917974566 12754197
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9617596541
MESH:D009203 Myocardial Infarction pirinixic acid 5.4519151258
MESH:D009203 Myocardial Infarction resveratrol 5.4516525036 16317513 17188708 17125593 17015251 16456233
MESH:D017202 Myocardial Ischemia resveratrol 8.4617125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.4612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.7216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.7216411023
MESH:D009205 Myocarditis resveratrol 4.5517322642
MESH:D009361 Neoplasm Invasiveness Curcumin 4.1718495463
MESH:D009369 Neoplasms alitretinoin 7.7416946489
MESH:D009369 Neoplasms pirinixic acid 7.7417405874
MESH:D009369 Neoplasms Tretinoin 7.7416946489 16594593
MESH:D009374 Neoplasms, Experimental resveratrol 3.808985016
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.3212497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1118481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 15.1616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.1614600291
MESH:D009421 Nervous System Malformations Tretinoin 15.169125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.4218462866
MESH:D009436 Neural Tube Defects Tretinoin 2.929142499
MESH:D009447 Neuroblastoma Isotretinoin 3.9417368321
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.7918514411
MESH:D019636 Neurodegenerative Diseases resveratrol 7.7917652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.2017929310
MESH:D009765 Obesity Curcumin 7.1219297423
MESH:D009765 Obesity Dietary Fats 7.1221332399 11836018 18457598 18674790 16723640 19632207 17217161 20518802 20132043
MESH:D009765 Obesity pirinixic acid 7.1220558911
MESH:D010024 Osteoporosis Curcumin 3.3418719352
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.0617513867
MESH:D010051 Ovarian Neoplasms Curcumin 7.5319020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 7.5319401270
MESH:D010051 Ovarian Neoplasms Tretinoin 7.5316936753
MESH:D010146 Pain Acetaminophen 6.0316870215
MESH:D010146 Pain Tretinoin 6.0316870215
MESH:D010190 Pancreatic Neoplasms Curcumin 5.1919401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.1915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.6910923243
MESH:D017499 Porokeratosis alitretinoin 5.7916144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0512371664
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 15.1918769834
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 15.1916679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.1911399792 11896295 11118676 11222880
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5715572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6920887781
MESH:D011471 Prostatic Neoplasms Am 80 1.9016289102
MESH:D011471 Prostatic Neoplasms Calcitriol 1.9016289102 15754350 12479363 18247401 16644109
MESH:D011471 Prostatic Neoplasms Curcumin 1.9018226269 18156803 10851300 11398177 15129424 12497104 18769126
MESH:D011471 Prostatic Neoplasms Estradiol 1.9016740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 1.9016205645
MESH:D011471 Prostatic Neoplasms resveratrol 1.9017804756 17718901 17675339 16731767 17636462 15767336
MESH:D011507 Proteinuria Tretinoin 3.4116636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.1015861022 16919318
MESH:D011565 Psoriasis Am 80 5.9016819260
MESH:D011565 Psoriasis Cyclosporine 5.9016882103
MESH:D011596 Psychomotor Disorders Isotretinoin 5.7118769834
MESH:D011625 Pterygium Tretinoin 4.5816723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.3419168576
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.6112832656 12490602 11597910
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 5.6117975199 17365031 17322281 15814490
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3716325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.2319058328
MESH:D015427 Reperfusion Injury resveratrol 6.2317520802 16314181 15827377 17058453 16317513
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.8318379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9016283617 16116481
MESH:D012509 Sarcoma Curcumin 3.9318462866
MESH:D018805 Sepsis Curcumin 3.9018389075
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.8718724381
MESH:D012878 Skin Neoplasms gingerol 16.9119481070
MESH:D012878 Skin Neoplasms resveratrol 16.918985016 15837718
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 16.918532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.9116192470
MESH:D012878 Skin Neoplasms Tretinoin 16.9116467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7316709447
MESH:D013274 Stomach Neoplasms Tretinoin 1.7917261132
MESH:D013276 Stomach Ulcer Amiodarone 6.8518087811
MESH:D013276 Stomach Ulcer Curcumin 6.8519188055 16631530
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.3016321402
MESH:D013610 Tachycardia Amiodarone 4.0911238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.9919225199
MESH:D013733 Testicular Diseases pyrazole 4.616499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013959 Thyroid Diseases Amiodarone 11.3419731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.3412697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.8716026305 17045167
MESH:D013971 Thyrotoxicosis Amiodarone 4.6518020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.4719048282
MESH:D014062 Tongue Neoplasms resveratrol 9.3016227395
MESH:D014062 Tongue Neoplasms Tretinoin 9.3016051514
MESH:D016171 Torsades de Pointes Amiodarone 3.9811989578 17467628
MESH:D014376 Tuberculosis Tretinoin 3.1016040207
MESH:D001749 Urinary Bladder Neoplasms Curcumin 2.8118593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.0518462866
MESH:D014581 Urticaria Acetaminophen 2.7810982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 8.9217473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.9216129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.8314692618
MESH:D014594 Uterine Neoplasms resveratrol 8.8317044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.4016752155
MESH:D014605 Uveitis Cyclosporine 3.771336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3514671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.0917488730
MESH:D014820 Vitiligo Tretinoin 3.8516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D015430 Weight Gain Dietary Fats 3.5616723640
MESH:D009396 Wilms Tumor Tretinoin 3.7916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2317120751
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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