AutismKB 2.0

Annotation Detail for RPL35


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RPL35 ( - )
Gene Full Name: ribosomal protein L35
Band: 9q33.3
Quick LinksEntrez ID:11224; OMIM: NA; Uniprot ID:RL35_HUMAN; ENSEMBL ID: ENSG00000136942; HGNC ID: 10344
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03010Ribosome
Pathway IDPathway Name
Diabetes pathways
Metabolism of proteins
Regulation of beta-cell development
Influenza Infection
Gene Expression
3' -UTR-mediated translational regulation
No data
No data
Pathway IDPathway Name
500526L13a-mediated translational silencing of Ceruloplasmin expression
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of RPL35 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RPL35 mRNAaffects expression 16483693
D001554 Benzene Benzene results in decreased expression of RPL35 mRNAdecreases expression 15878777
C032036 bromobenzene bromobenzene results in decreased expression of RPL35 mRNAdecreases expression 15056800
C032036 bromobenzene bromobenzene results in increased expression of RPL35 mRNAincreases expression 12628495
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RPL35 mRNAaffects expression 15963342
C099555 CD 437 CD 437 results in increased expression of RPL35 mRNAincreases expression 12958071
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of RPL35 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of RPL35 mRNA]decreases reaction|increases expression 17942915
D018684 Glycine Agents Glycine Agents results in decreased expression of RPL35 mRNAdecreases expression 16532367
D009532 Nickel MT1 affects the reaction [Nickel affects the expression of RPL35 mRNA]affects expression|affects reaction 16166738
D009532 Nickel MT2 affects the reaction [Nickel affects the expression of RPL35 mRNA]affects expression|affects reaction 16166738
C006253 pirinixic acid pirinixic acid results in increased expression of RPL35 mRNAincreases expression 18445702
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RPL35 mRNAdecreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D055371 Acute Lung Injury Nickel 9.7516166738
MESH:D055371 Acute Lung Injury pirinixic acid 9.7518653653
MESH:D000236 Adenoma Diethylnitrosamine 2.9310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 18.4619052882 16434500 17162532 18056438 17620307 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.4616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.4616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000741 Anemia, Aplastic Benzene 4.4811369114 14761424 17661222
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001855 Bone Marrow Diseases Benzene 5.4516183116
MESH:D001943 Breast Neoplasms Benzene 2.0311921183 17162533
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0317474063
MESH:D001943 Breast Neoplasms Nickel 2.0315986119
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0320435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9516097048 10355542 16011737 15721981 16124888 15700767 16192424 15673190 18705752 3786805 16050911 16227642
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.643084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6418788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.6418691550 18506893 16681979 16878318 18978308 17138121 18056438 19701751 16807293 19919837 11831363 3084413 16830150 17761372 19822196 17055752 16779866 19052882 19519916 20007298 19418558 18210153 18971187 19539802 16328049 16288022 10737359 19171122 19394651 18788625 20512989 18393292 16569478 19335982 16698587 17978847 17428255 3581430 20727157 21159647 16540662 17173139 20524982 20514400 20101231 18665156 17162532 10672840 19107877 19383236 20935162 18785209 19208518 16502159 20084675 20432363 16935385 18494052 20214788
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.957505956 2727394 17174075 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.7416835633
MESH:D002779 Cholestasis pirinixic acid 2.9319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1512621046 8697196 15668235 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Benzene 2.7115643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7115322242 20055451 10048152
MESH:D003872 Dermatitis Benzene 4.9415902427
MESH:D017449 Dermatitis, Allergic Contact Nickel 4.1217100760 19470301 17244072
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003877 Dermatitis, Contact Nickel 4.782952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3217107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.4417562736 11529661 12958197 10915739 12392966 17906064 16177239 14986274 19420014 14550746 19085960 18071297 16393943 15968718 19164858 11739529 16485898 19416960 19923254 18713872 16081117 12540782 15619225 17522070 16109766 11834606 10774834 11421492 19370779 19739265 2444490 16227642 12594235 14725611 11461765 16781746 10663392 11743745 12153990 12705907 11287661
MESH:D056486 Drug-Induced Liver Injury bromobenzene 12.4410092053 12628495
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.447179309 21278145 19336974 15998439 6884620 4309450 11566570 7440962 15027814 10915739 10092053 17522070 2869522 6623471 3786805 16177239 7120509 15968718 19085960 3732212 9327722 16227642
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.4419107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.4420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1216714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.9312795759 19224547 15959796 61145 17595544 16045604 12631006 16239168
MESH:D005234 Fatty Liver Diethylnitrosamine 13.9320387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 13.9319236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.1918705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.1920067830
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4011294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006402 Hematologic Diseases Benzene 4.8016183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 8.8519772884 18467677 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.8515340226 12621046 16120746
MESH:D015658 HIV Infections Nickel 3.8817263646
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2618606429 16354765 15340226 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Benzene 5.4717940673
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4718670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007249 Inflammation Diethylnitrosamine 8.8118785209
MESH:D007249 Inflammation Nickel 8.8116166738
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.8112878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2712587719 15629191
MESH:D007938 Leukemia Benzene 3.4514694614 17119257 18335105 15935818
MESH:D007951 Leukemia, Myeloid Benzene 4.4617506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.7219478238
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.8516943688 11408273 17157831 16221502 11903743 16239168 21278145 17174718 17334410
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.8520032147 18522880 18665156 19638242 18407596
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4610355542 18412020 12741479 18705752 12445421 14748882 15650968 14512876 17721639 16136751 15893842 18481824 16027843 17922224 12632512 12632514 18317297 12445418 12586293 12389079 18263696 18472094 15996030 16033810 14716833 12666154 17565644 17481882 15959796 17557913 18429990 18277467 18156304 14724832 17525996 17944888 12667390 16248980 17766677 17823541 16192424 18472332 17976157 11481614 12958196 14716496 17714472 15057751 17640975 15338365 18420326 18395914 16116963 17900296 12546737 12649538 18395095 18006644 15730626 16015684 12609069 17698563 18339082 15370692 16011737 18054572 15673190 12898905 15052691 15931870 13678700 17805973 18205269 20821823 15123356 14620537 18251166 18166357 15362042 16097048 18418968 15925388 17761835 18210741 15818738 16638106 15876570 17869086 17708605 18187930 18279442 18376398 17631135
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4612878042
MESH:D008107 Liver Diseases Acetaminophen 6.6619014921 11587558 19784758 12587719 16610002 16611625 19460945 12969438
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.6615830285 16246199 17285989 15720792 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 6.6617034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.8517185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.8516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.0719294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.0719690152 15885732 20137499 18648771 19426721 20492335 18644402 19294768 12771043 2422723 19499222 10737359 12112319 19073162 19833225 19254457 16942905 20434301 21278145 19642983 19427195 19850985 20452335 19090486 19812893 21071580 19638242 20583210 18754104 2862719 21047994 19551842 9163691 19996281 19255062 15175105 20501860 21167192 20405173 20118626 18978307 19256749 18977376 20101389
MESH:D008113 Liver Neoplasms pirinixic acid 11.0720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0716984957
MESH:D008114 Liver Neoplasms, Experimental Benzene 14.8512562636
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.8515583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.8519004024 16267830 18282651 18093689 9362446 18079962 16842330 18544905 2563599 18775883 17942915 3124819 19519916 19539802 18164116 19009564 18253720 19126423 17174075 21159647 17854601 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.8512151625
MESH:D017563 Lung Diseases, Interstitial Benzene 5.0214698565
MESH:D008175 Lung Neoplasms Benzene 3.5412562636
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.5420512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5411884234 19555203
MESH:D008223 Lymphoma Benzene 3.8317119257 17584886
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.6412562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 3.3911921183
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D009101 Multiple Myeloma Benzene 3.7617119195
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.613581430 9029167
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009436 Neural Tube Defects Benzene 3.7615643154
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.5818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.5820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases Benzene 4.3115935809 17119257 15913788 15727169 15612468 17479406 16737584 17178637 15576619
MESH:D010051 Ovarian Neoplasms Benzene 5.5712562636
MESH:D010051 Ovarian Neoplasms CD 437 5.5717474084
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4616540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.682563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811118676 11399792 11896295 11222880
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013274 Stomach Neoplasms Benzene 2.6812562636
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6818456281
MESH:D013953 Thymus Neoplasms Benzene 5.1510850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.097505956
MESH:D001749 Urinary Bladder Neoplasms CD 437 3.4316720286
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014594 Uterine Neoplasms Benzene 4.4912562636
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:15380 Diabetes pathways
REACT:71 Gene Expression
REACT:6167 Influenza Infection
REACT:17015 Metabolism of proteins
REACT:13698 Regulation of beta-cell development
KEGG:03010 Ribosome
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved