AutismKB 2.0

Annotation Detail for CHN1


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Basic Information Top
Gene Symbol:CHN1 ( ARHGAP2,CHN,DURS2,RHOGAP2 )
Gene Full Name: chimerin (chimaerin) 1
Band: 2q31.1
Quick LinksEntrez ID:1123; OMIM: 118423; Uniprot ID:CHIN_HUMAN; ENSEMBL ID: ENSG00000128656; HGNC ID: 1943
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by Rho GTPases
Pathway IDPathway Name
200165Regulation of RAC1 activity
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2150Duane retraction syndrome
No data
No data
Desease Name
Duane retraction syndrome 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CHN1 mRNAaffects expression 16483693
D003024 Clozapine Clozapine results in decreased expression of CHN1 mRNAdecreases expression 14647396
C009160 cyclonite cyclonite affects the expression of CHN1 mRNAaffects expression 19417177
D016572 Cyclosporine Cyclosporine results in increased expression of CHN1 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CHN1 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in increased expression of CHN1 mRNAincreases expression 18035473
D006220 Haloperidol Haloperidol results in decreased expression of CHN1 mRNAdecreases expression 14647396
D013654 Taurine Taurine results in decreased expression of CHN1 mRNAdecreases expression 16579726
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CHN1 mRNAaffects cotreatment|increases expression 17942748
D015215 Zidovudine Zidovudine results in decreased expression of CHN1 mRNAdecreases expression 16894629
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0811752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.049612607
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000380 Agranulocytosis Clozapine 5.2716160616 14617031 12649775
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001321 Autistic Disorder Haloperidol 2.7318080171 19368416
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4516120746 18850075 18670907
MESH:D002375 Catalepsy Haloperidol 5.1515215559 1977408
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 8.2019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2017333356 17110522 17681005 15861022 16105132 11677210 16919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615668235 8697196 16354765 15340226 12621046
MESH:D003072 Cognition Disorders Clozapine 5.1817123785
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D016757 Death, Sudden, Cardiac Haloperidol 5.0320210726
MESH:D003704 Dementia Haloperidol 4.7511575062
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.6316402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6317107852
MESH:D058065 Diabetic Cardiomyopathies Taurine 6.2916025228
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.8215331141
MESH:D056486 Drug-Induced Liver Injury Taurine 4.439328219
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.4320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.6611462148
MESH:D004362 Drug Toxicity Zidovudine 8.6615040536
MESH:D004370 Duane Retraction Syndrome marker/mechanism
MESH:D050171 Dyslipidemias Clozapine 4.3016402076
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Cyclosporine 14.1819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.1815345470
MESH:D005234 Fatty Liver Zidovudine 14.1818299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Cyclosporine 9.2112639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4110048152 11294989
MESH:D006402 Hematologic Diseases Zidovudine 4.9012579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1116120746 15340226 12621046
MESH:D015658 HIV Infections Zidovudine 3.5717358032 11141242 11363243 11698656 20032539
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116354765 16959395 18606429 8697196 15340226
MESH:D006948 Hyperkinesis Clozapine 5.1516046005
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation Flavonoids 5.2717296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2712878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4318776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 8.0512371664
MESH:D007680 Kidney Neoplasms Zidovudine 8.0512579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.5820370541
MESH:D008064 Lipidoses Clozapine 4.0817567588
MESH:D008106 Liver Cirrhosis, Experimental Taurine 2.8915893842 15931870
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.8912878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2012151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5611884234 19555203
MESH:D008175 Lung Neoplasms Zidovudine 2.5618800350
MESH:D001523 Mental Disorders Clozapine 9.1616856516
MESH:D001523 Mental Disorders Haloperidol 9.1616856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.5619142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.1017358032
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009765 Obesity Clozapine 3.0518515891 19142110
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311896295 11118676 11399792 11222880
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D011595 Psychomotor Agitation Haloperidol 5.1711575062
MESH:D011618 Psychotic Disorders Clozapine 9.5615331141
MESH:D011618 Psychotic Disorders Haloperidol 9.5611575062
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012559 Schizophrenia Clozapine 4.1720452607 20168265 11151749 18806925 20521320 17667964 19369910 20580759 17123785 17726453 18855531 11763009 20107430 20521326 16141801
MESH:D012559 Schizophrenia Haloperidol 4.1719369910 20107430 18513383 1830565
MESH:D012640 Seizures cyclonite 4.6419417177
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.9020210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.9712579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D015430 Weight Gain Clozapine 4.6220521320 20107430 20564506 17502770 16402076 16141801
MESH:D015431 Weight Loss Clozapine 5.3117933447
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
REACT:11044 Signaling by Rho GTPases
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26473
    • No data
    Releated disease ID Related disease Name
    PA443939Duane Retraction Syndrome
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA451578tacrolimus
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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