AutismKB 2.0

Annotation Detail for SEC63


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Basic Information Top
Gene Symbol:SEC63 ( ERdj2,PRO2507,SEC63L )
Gene Full Name: SEC63 homolog (S. cerevisiae)
Band: 6q21
Quick LinksEntrez ID:11231; OMIM: 608648; Uniprot ID:SEC63_HUMAN; ENSEMBL ID: ENSG00000025796; HGNC ID: 21082
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03060Protein export
hsa04141Protein processing in endoplasmic reticulum
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
liver disease, polycystic
No data
Desease Name
Polycystic liver disease
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SEC63 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of SEC63 mRNAdecreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SEC63 mRNAaffects expression 21346803
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SEC63 mRNAdecreases expression 20127859
D016572 Cyclosporine Cyclosporine results in increased expression of SEC63 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SEC63 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SEC63 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SEC63 mRNAaffects cotreatment|increases expression 17942748
D007213 Indomethacin Indomethacin results in decreased expression of SEC63 mRNAdecreases expression 16984733
D018038 Sodium Selenite Sodium Selenite results in increased expression of SEC63 mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of SEC63 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SEC63 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SEC63 mRNAdecreases expression 18796159
D014212 Tretinoin Tretinoin results in increased expression of SEC63 mRNAincreases expression 16604517
D014810 Vitamin E Vitamin E results in decreased expression of SEC63 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7614745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0411752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.2820127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.2814692618
MESH:D000230 Adenocarcinoma Indomethacin 7.2816537180
MESH:D000236 Adenoma Benzo(a)pyrene 7.116695378
MESH:D000236 Adenoma Indomethacin 7.1111497255
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000505 Alopecia Tretinoin 3.7315955085
MESH:D016301 Alveolar Bone Loss Indomethacin 5.5917225004
MESH:D000544 Alzheimer Disease Indomethacin 2.7317627676 15579461
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001014 Aortic Aneurysm Indomethacin 5.0110231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 12.3119183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 12.3110388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D018771 Arthralgia Indomethacin 5.392160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.4815885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.4816412693
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.8611248219
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.8616292516
MESH:D001249 Asthma Tretinoin 2.3816456186
MESH:D001471 Barrett Esophagus Tretinoin 4.5616935849
MESH:D001477 Bartter Syndrome Indomethacin 5.1610684365
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.4116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001929 Brain Edema Indomethacin 5.2411481608
MESH:D002545 Brain Ischemia Indomethacin 4.6112524144
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3720146248 17474063
MESH:D001943 Breast Neoplasms Indomethacin 2.3717401462
MESH:D001943 Breast Neoplasms Tamoxifen 2.3719066611 15565566 19289846 19189212 19155303 19221464 19103187 15668708 20390343 17893378 16273361 18815881 20065188 20544844 18997820 18351453 20859285 21138602 19059307 19115204 16818667 19487384 18984771 19011961 20005174 16202921 21152245 17049068 19244106 16873071 19200415 19410462 18821012 19084267 20135344 17440819 17261762 19288272 17242785 19142967 11161223 18855134 18425577 19189210 18629630
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3720435547
MESH:D001943 Breast Neoplasms Tretinoin 2.3716443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7816813970
MESH:D002056 Burns Indomethacin 4.8810459503
MESH:D002100 Cachexia Indomethacin 5.2015141370 16537180 11239499 15625704
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6819066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3816168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.1016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.1016705839
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 9.1016391822
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 9.1016924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 9.101917145
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.9211053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.5514736730 18791128 11352223
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.4317341418
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.7920419170
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 7.7915482327 12636206
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.7916096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 18670907 16120746
MESH:D002386 Cataract Tretinoin 3.1717460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.896135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8912371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002764 Cholecystitis Indomethacin 5.3911181007
MESH:D002779 Cholestasis Cyclosporine 8.1219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.1217681005 11677210 16105132 17333356 16919318 17110522 15861022
MESH:D002822 Choriocarcinoma Tretinoin 5.3816461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.948697196 15668235 16354765 12621046 15340226
MESH:D002972 Cleft Palate Tretinoin 5.949407595
MESH:D003092 Colitis Tretinoin 3.8817035595
MESH:D003110 Colonic Neoplasms Indomethacin 2.6111260862 15637740 15936596 15963497 15786552 15625704
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3618059344 12606626 11197048 17054584
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D018352 Coronavirus Infections Indomethacin 5.9317302372
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8420055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.8414991402 17551590 9664655 16925845 9224671 10589399 8800419 9125849 9142499 9211117
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8419769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.4918551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5419031437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6019279558
MESH:D003967 Diarrhea Indomethacin 3.957907874 7237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.2921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.2918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.2915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.3417190690 18446180 16326151 16133044 18043480 12774134
MESH:D004381 Duodenal Ulcer Indomethacin 4.3017329845 16699067 17151854 11595431 17045617 11595415 11991626 10671773 17351913 11535926 17202747
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004487 Edema Indomethacin 7.387907874 7990266 16100529 8273558 10653021 19703484 8985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.6818230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.6818230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.4912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.4919031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.7320544844 16202921 17893378 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 7.7316569247
MESH:D004715 Endometriosis Indomethacin 9.5115652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.5110568697 9294722
MESH:D019446 Endotoxemia Indomethacin 4.6918509659
MESH:D004751 Enteritis Indomethacin 4.9610567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.1617980183
MESH:D004802 Eosinophilia Indomethacin 4.2311298111
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.7216530937
MESH:D004938 Esophageal Neoplasms Indomethacin 4.7211005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.1811564622
MESH:D005124 Eye Abnormalities Tretinoin 9.1816938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 13.8919224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.8915345470
MESH:D005234 Fatty Liver Tamoxifen 13.8919224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005334 Fever Indomethacin 4.2517627676 11852909 10431976
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3819069698
MESH:D005354 Fibrosarcoma Indomethacin 5.0910962813
MESH:D005355 Fibrosis Cyclosporine 22.7212639820 12168785
MESH:D005355 Fibrosis Indomethacin 22.7217994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 22.7220067830
MESH:D005355 Fibrosis Tretinoin 22.7217994277
MESH:D005499 Folliculitis Indomethacin 5.3911298111
MESH:D005756 Gastritis Indomethacin 4.9615046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D005909 Glioblastoma Indomethacin 7.6112870263
MESH:D005909 Glioblastoma Tretinoin 7.6117312396
MESH:D005910 Glioma Indomethacin 3.2716487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.4011849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006073 Gout Indomethacin 5.5511248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 8.2315482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.2316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 16.5320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 16.5310048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 16.5314991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 16.5316080930
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.7115633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.8415135802
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616959395 8697196 16354765 15340226 18606429
MESH:D006930 Hyperalgesia Indomethacin 8.3912727271
MESH:D006930 Hyperalgesia Tretinoin 8.3916870215
MESH:D034321 Hyperamylasemia Indomethacin 5.9317883296
MESH:D006940 Hyperemia Indomethacin 5.2012524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7416778211
MESH:D006949 Hyperlipidemias Indomethacin 4.3117546600
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816945680 16569931
MESH:D007077 Ileal Diseases Indomethacin 5.2418306037 10574470
MESH:D007079 Ileitis Indomethacin 5.5510651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.5916133044
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Indomethacin 8.753291741 12568917 7812673
MESH:D007249 Inflammation Tamoxifen 8.7519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.7512200463 12878042
MESH:D007251 Influenza, Human Vitamin E 4.4316624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.3614714311
MESH:D007410 Intestinal Diseases Indomethacin 10.4811686837 15831440 15610444 17994277 18236018 11713966 11855677 17329856 10210152
MESH:D007410 Intestinal Diseases Tretinoin 10.4817994277
MESH:D019586 Intracranial Hypertension Indomethacin 5.5915241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.4016580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.4015992940 17551590
MESH:D007579 Jejunal Diseases Indomethacin 5.2410574470 18306037 16133968
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 10.6018776723 8314463 10903974
MESH:D007674 Kidney Diseases Indomethacin 10.6017190690
MESH:D007674 Kidney Diseases Vitamin E 10.6012488133
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.7516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.7516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 18.7512371664
MESH:D007680 Kidney Neoplasms Tamoxifen 18.7518625569
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 4.0212228301 10320625 11703811
MESH:D007938 Leukemia Tretinoin 2.8317143497
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 4.0315631656 16572323 10785260
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8416482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 4.1418360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.1419850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2415748426 17301526 16766008 16935935 9834237 19035177 17217047 17294898 16140955 17339181 17368321 16823087 16331271 19029980 17649720 17506722 19642359 17712046 19075265 16891316 17361223 17107899 19225113 16788101 12679006
MESH:D007964 Leukocytosis Indomethacin 5.5916537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.9317980183
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.419224671
MESH:D008064 Lipidoses Tamoxifen 3.2515342952 17567588
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.9311479899
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 6.9118194892
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.9118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.9112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.9118397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.9116169303
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.087678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.0820195826 21137059
MESH:D008113 Liver Neoplasms Tamoxifen 11.0816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0816984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.016135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0112151625
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.7517053015 18569708 18520028 20869020 20064080 18816296 6695378 20464547 20135361
MESH:D008175 Lung Neoplasms Indomethacin 6.7511053908 11497255 16537180
MESH:D008175 Lung Neoplasms Tamoxifen 6.7518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.7511884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 6.7511062179
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7111731420 16827153 14580682 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.7619453300
MESH:D008527 Medulloblastoma Tretinoin 2.8317453147
MESH:D008545 Melanoma Tamoxifen 3.3512393984 19393235
MESH:D008545 Melanoma Tretinoin 3.3516752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3815990972
MESH:D008591 Meningomyelocele Tretinoin 4.6016940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D008881 Migraine Disorders Indomethacin 3.7711903285
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.0216381670
MESH:D009062 Mouth Neoplasms Indomethacin 9.0212636206
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1517596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.0018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.007678174 18551238
MESH:D009362 Neoplasm Metastasis Indomethacin 6.1211053908 16537180 11239499
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.1219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2011141357
MESH:D009369 Neoplasms Tretinoin 5.2016594593 16946489
MESH:D009374 Neoplasms, Experimental Indomethacin 4.3110663608 15625704
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2219200415 19189210 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.0614600291
MESH:D009421 Nervous System Malformations Tretinoin 10.069125849
MESH:D009436 Neural Tube Defects Tretinoin 3.149142499
MESH:D019636 Neurodegenerative Diseases Indomethacin 4.0612349958
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.396374098
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.3316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.3316049721
MESH:D010003 Osteoarthritis Indomethacin 3.747009135
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3816936753
MESH:D010146 Pain Indomethacin 7.3713679232 17627676 17440234 3291741
MESH:D010146 Pain Tretinoin 7.3716870215
MESH:D010149 Pain, Postoperative Indomethacin 4.9012538197 18702446
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5015976015
MESH:D010195 Pancreatitis Indomethacin 4.0715028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.9316537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.2512349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.9311903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010437 Peptic Ulcer Indomethacin 5.3411148446
MESH:D010518 Periodontitis Indomethacin 5.1317225004
MESH:C536330 Polycystic liver disease marker/mechanism
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D047928 Premature Birth Indomethacin 5.3017000239
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811399792 11118676 11222880 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0517292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.0518760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0515067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0515084515
MESH:D011507 Proteinuria Indomethacin 9.8411849393
MESH:D011507 Proteinuria Tretinoin 9.8416636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.5115861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D011625 Pterygium Tretinoin 4.9916723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2516283617 16116481
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1818551238
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.7419755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.7416192470
MESH:D012878 Skin Neoplasms Tretinoin 9.7416467112
MESH:D013088 Spermatocele Ethinyl Estradiol 12.3016709447
MESH:D013088 Spermatocele Tamoxifen 12.3016709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2319457130
MESH:D013272 Stomach Diseases Indomethacin 4.6110486359 16184426 17160473 16113693 15472012 18545984 10215738 17638125 15038085 16280098 18209964 10192188 17207306
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.4720155912 2093021
MESH:D013274 Stomach Neoplasms Indomethacin 3.4715609394
MESH:D013274 Stomach Neoplasms Tretinoin 3.4717261132
MESH:D013276 Stomach Ulcer Indomethacin 3.7211595431 16150113 17654042 10750652 18726076 14567935 10423059 16755016 12787963 18299717 16252198 15138204 11595415 12077510 18209962 17918041 16169175 18087811 12500499 11906479 16934674 11729361 10878458 12498302 11145282 18431645 17895592 18237397 18193104 17977527 15255614 16397915 1323529 15104355 17657623 17135157 18181030 12467913 17627676 11523592 18543354 16631530
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms Indomethacin 7.7514736730 11352223 18791128
MESH:D013964 Thyroid Neoplasms Tretinoin 7.7516026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9216051514
MESH:D014376 Tuberculosis Tretinoin 3.3116040207
MESH:D014456 Ulcer Indomethacin 5.0910574470 17380554
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.3216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.3216049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.3217053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.3217572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.6510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.6510091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8116129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.8316752155
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6815869587 14671159
MESH:D014820 Vitiligo Tretinoin 4.2216761959
MESH:D014839 Vomiting Indomethacin 4.9611897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D009396 Wilms Tumor Tretinoin 4.0916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
KEGG:03060 Protein export
KEGG:04141 Protein processing in endoplasmic reticulum
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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